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eukaryotic translation initiation factor 2-alpha kinase 2

The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

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eukaryotic translation initiation factor 2-alpha kinase 2

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  1. EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 BackgroundThe protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] SynonymsEIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2; PKR; PRKR; EIF2AK1; interferon-induced, double-stranded RNA-activated protein kinase; p68 kinase; eIF-2A protein kinase 2; P1/eIF-2A protein kinase; tyrosine-protein kinase EIF2AK2; interferon-inducible elF2alpha kinase; double stranded RNA activated protein kinase; protein kinase, interferon-inducible double stranded RNA dependent; Recombinant Proteins Cell & Tissue Lysates Cat.#Product name Source (Host) SpeciesTag Price EIF2AK2-1385HRecombinant Human EIF2AK2 Protein (2-551 aa), His-taggedYeastHuman His+Inquiry

  2. EIF2AK2-473HRecombinant Human EIF2AK2 Protein (2-551 aa), His-SUMO-taggedE. coliHuman His-SUMO +Inquiry EIF2AK2-3148HRecombinant Human EIF2AK2 Protein, GST-taggedInsect cellsHuman GST+Inquiry EIF2AK2-3149HRecombinant Human EIF2AK2 Protein, GST-taggedWheat GermHuman GST+Inquiry EIF2AK2-332HRecombinant Human EIF2AK2 Protein, MYC/DDK-taggedHEK293Human MYC/DDK +Inquiry EIF2AK2-298HRecombinant Human EIF2AK2, GST-tagged, ActiveSf 9 Insect cellsHuman GST+Inquiry EIF2AK2-12350HRecombinant Human EIF2AK2, His-taggedE. coli Human His+Inquiry EIF2AK2-31020THRecombinant Human EIF2AK2 Human +Inquiry EIF2AK2-563HRecombinant Human EIF2AK2 protein, His-taggedE. coliHuman His+Inquiry Eif2ak2-2727MRecombinant Mouse Eif2ak2 protein, His & T7-tagged E. coliMouse His/T7+Inquiry EIF2AK2-489MRecombinant Mouse Eif2ak2 protein, GST-tagged Insect cellsMouse GST+Inquiry EIF2AK2-5076MRecombinant Mouse EIF2AK2 Protein Mammalian Cells Mouse His+Inquiry

  3. EIF2AK2-2044RRecombinant Rat EIF2AK2 ProteinMammalian CellsRat His+Inquiry Eif2ak2-2728RRecombinant Rat Eif2ak2 protein, His & T7-tagged E. coliRat His/T7+Inquiry EIF2AK2-1414RRecombinant Rhesus monkey EIF2AK2 Protein, His-taggedMammalian Cells Rhesus Macaque His+Inquiry EIF2AK2-6057CRecombinant Chicken EIF2AK2Mammalian CellsChickenHis+Inquiry EIF2AK2-6421ZRecombinant Zebrafish EIF2AK2Mammalian CellsZebrafishHis+Inquiry Involved Pathway EIF2AK2 involved in several pathways and played different roles in them. We selected most pathways EIF2AK2 participated on our site, such as Protein processing in endoplasmic reticulum, Hepatitis C, Measles, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF2AK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site. Pathway NamePathway Related Protein Protein processing in endoplasmic reticulumUBE4B; HSP26; DNAJC5AA; ERLEC1; MAPK9; BAG1; TRAF2; BAG2; SSR4; UBE2E1

  4. Hepatitis CMAPK12; CLDN1; CLDN2; SOS1; IFNA5; PIK3CA; PIK3R5; OAS2; CLDN16; GSK3B MeaslesHSPA8; CCNE1; IL1B; CLEC4M; SLAMF1; IFNA17; OAS3; IFNGR2; FYN; HSPA1B Influenza APABPN1L; PRSS3; HLA-DRB1; H2-AA; IFNGR2; HLA-DQB1; SOCS3; IFNA2; Ccl12; IRF3 Herpes simplex infectionPVRL1B; CCL5; HLA-G; CLOCKA; SRSF5A; IKBKB; SP100; EIF2AK4; HLA-DPA1; HNRPKL Epstein-Barr virus infectionCSNK2A2; SYK; EIF2AK3; POLR1D; POLR3C; POLR2C; HLA-B; IL10RA; PIK3CG; POLR2J3 Viral carcinogenesisSTAT3; HIST2H2BE; HIST1H2BH; PRKACA; HIST1H2BI; SNW1; BAK1; TTC6; CREB3L2; PIK3R1 Protein Function EIF2AK2 has several biochemical functions, for example, ATP binding, double-stranded RNA binding, eukaryotic translation initiation factor 2alpha kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF2AK2 itself. We selected most functions EIF2AK2 had, and list some proteins which have the same functions with EIF2AK2. You can find most of the proteins on our site. FunctionRelated Protein Function ATP bindingRelated Protein SETX; CAMK2B1; CDKL4;

  5. PIP5K1A; ABCB6A; PFKP; VCP; TTF2; HSPA1L; CHEK1 Function double-stranded RNA bindingRelated Protein PRKRIP1; MTDH; EIF4A1; ADARB1; BARHL1; APTX; OAS1; TLR7; DHX15; OASL1 Function eukaryotic translation initiation factor 2alpha kinase activityRelated Protein EIF2AK1; EIF2AK2; ALPK2; EIF2AK4; EIF2AK3 Function non-membrane spanning protein tyrosine kinase activityRelated Protein FYN; MATK; JAK2B; STK16; Fert2; HCK; PTK2; RIPK2; PTK6; PKDCC Function poly(A) RNA bindingRelated Protein DDX41; APOBEC3F; HERC5; SUMO1; SECISBP2; C22orf28; MRPL9; FUBP3; FTSJ3; PNPT1 Function protein bindingRelated Protein IFT43; FCN2; BCL2L2; MSI2; ELK3; USP34; PPIB; ADRBK1; TPD52; RDH12 Function protein kinase activityRelated Protein PRKG1A; MAP2K1; CDC7; DYRK1B; MAP3K1; DAPK2A; DCLK1A; POMK; IRAK4; PHKG1B Function protein phosphatase type 2A regulator activityRelated Protein PPP2R5A; PPP2R2A; PPP2R1A; PPP2R2D; PPP2R5E; PPP2R5EA; PPP2R2CA; PPME1; PPP2R1B; PPP2R4 Function protein serine/threonine kinase activityRelated Protein

  6. PRKCB; PAK4; ACVR1L; SGK3; RIPK4; RPS6KC1; CDK5; TNIK; ICK; ALPK1 Interacting Protein EIF2AK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF2AK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF2AK2. EIF2S1; p27958-pro_0000037576; p27958-pro_0000037570; N/A; DHX30; US11

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