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African trypanosomiasis Trypanosoma brucei

African trypanosomiasis Trypanosoma brucei. Salivarian trypanosome groups. Trypanosoma vivax – Old and New World of large mammals – Mechanical transmission using many vectors Trypanosoma congolense – Old World of large mammals– Mouthpart development in Glossina

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African trypanosomiasis Trypanosoma brucei

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  1. African trypanosomiasisTrypanosoma brucei

  2. Salivarian trypanosome groups Trypanosoma vivax – Old and New World of large mammals – Mechanical transmission using many vectors Trypanosoma congolense – Old World of large mammals– Mouthpart development in Glossina Trypanosoma brucei/evansi – brucei group includes: T. brucei brucei –nagana in cattle T. brucei gambiense – chronic or West African sleeping sickness T. brucei rhodesiense – acute or East African sleeping sickness All have full development in Glossina evansi group includes: T. evansi – mechanical transmission in many vectors including vampire bats T. equinum – mechanically transmitted by horse flies T. equiperdum – sexually transmitted

  3. African trypanosomiasisTrypomastigote morphology

  4. African trypanosomiasisKinetoplast DNA changes

  5. African trypanosomiasisReservoir hosts gazelle gerenuk impala oryx

  6. African trypanosomiasis - Distribution West African = Trypanosoma gambiense East African = Trypanosoma rhodesiense

  7. African trypanosomiasisResistant and susceptible cattle N’dama Zebu

  8. African trypanosomiasisThe tsetse fly

  9. African trypanosomiasisLife cycle

  10. African trypanosomiasisAntigenic variation

  11. Immune response overview

  12. African trypanosomiasisDisease

  13. African trypanosomiasisDiagnosis

  14. African trypanosomiasisTreatment Suramin - Pentamidine (early) Melarsoprol (late) DFMO Aventis Pharm & WHO

  15. African trypanosomiasisPrevention and Control

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