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DNA 5-methylcytosine

DNA 5-methylcytosine

MeganBowie
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DNA 5-methylcytosine

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  1. DNA 5-methylcytosine • VLP Recombinant Protein

  2. DNA methylation is an important epigenetic modification that regulates transcription and thus affects gene expression. It is a popular research object in the fields of embryonic development, postnatal development, cancer, and the influence of environmental hormones on epigenetic inheritance. In mammals, DNA methylation is found to occur predominantly on cytosines followed by guanine residues (CpG). This type of methylation is referred to as CpG methylation, and cytosine methylated at the fifth carbon of the pyrimidine ring is called 5-methylcytosine (5mC). DNA methylation patterns vary across organisms. The mammalian genome is usually highly methylated and those CpG loci that can be methylated are not randomly distributed in the genome sequence. In the genome of healthy people, the CpG loci in CpG islands are generally unmethylated, while the CpG loci outside the CpG islands are usually methylated. Non-CpG methylation is prevalent in human embryonic stem cells (ES cells) and brain tissue. Meanwhile, non-CpG methylation plays key roles in plants. 

  3. Due to the influences of environment, disease, age and gender factors, DNA methylation is in a dynamic change process, in which DNA methylation can be established and maintained by DNA methyltransferase (DNMT) and it can be demethylated by DNA demethylase. Aberrant change of DNA methylation content and patterns is a significant factor in the occurrence and development of diseases. In cancer research, abnormal change in DNA methylation considered to be one of biomarkers for early diagnosis and the promising target for developing therapeutic approaches.

  4. Creative BioMart offers a variety of DNA methylation analysis services based on bisulfite conversion, treatment of methylation sensitive restriction enzyme and methylated DNA enrichment strategies. Different techniques provide information on DNA methylation at different levels, spanning from single site methylation in specific genes to genome-wide methylation content.

  5. Creative BioMart has organized a team of scientists with extensive experience in DNA methylation analysis to provide a flexible, one-stop service for your DNA methylation analysis project. We can help you with experimental design, carry out your experiments and data analysis. We can provide diversity methods for you to choose as you prefer, and we can also help recommend the most appropriate solution. Moreover, we can provide a customized combination of services for comprehensive and in-depth DNA methylation analysis. Our experienced experts can help you design the optimal research solution and eliminate all the hurdles in your research. If you are interested in DNA methylation analysis, please feel free to contact us, Creative BioMart provides you with professional and thoughtful service!

  6. Thank you ! Excerpt from: https://www.creativebiomart.net/epigenetics/services/dna-methylation-analysis-service/

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