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Afinitor 10mgAfinitor 10mg - Anticancer drugs | view uses, side effects and price | MHP

Afinitor 10mg is a derivative of Rapamycin (sirolimus) and works similarly to Rapamycin as an mTOR (mammalian <br>target of rapamycin) inhibitor @ MHP

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Afinitor 10mgAfinitor 10mg - Anticancer drugs | view uses, side effects and price | MHP

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  1. AFFINITOR | EVEROLIMUS 10MG | MILLIONHEALTHPHARMA DESCRIPTION Afinitor 10mg is a derivative of Rapamycin (sirolimus) and works similarly to Rapamycin as an mTOR (mammalian target of rapamycin) inhibitor. It is normally used as an immunosuppressant to prevent rejection of organ transplants. In a similar fashion to other mTOR inhibitors Everolimus' effect is solely on the mTORC1 protein and not on the mTORC2 protein. PRESCRIBE INFORMATION Afinitor 10mg tablets are mainly indicated for the treatment of Renal carcinoma. Afinitor 10mg tablets are mainly indicated for the treatment of Breast carcinoma. Afinitor 10mg tablets are mainly indicated for the treatment of Brain carcinoma. Afinitor 10mg tablet is also used in various advanced stage cancer in stomach, intestines or pancreas.

  2. MECHANISM OF ACTION Everolimus is an mTOR prohibitor, joints at high compatibility to FK506 binding protein 12, via producing drug complex whichinhibits the specific of mTOR. This inhibitiondecreases the activity of effectors downstream, that may cause blockage of cell progression from G1 into S phase, subsequently causes cell growth arrest and apoptosis PROPERTIES Ingredients : Everolimus Strength : 10mg Package : 10 tablets PHARMACOKINETICS ABSORPTION The high plasma concentration time of Everolimus is 1 to 2 hours. The effect of food with Afinitor 10mg that with heavy meal: Reduction of systemic exposure to Afinitor 5mg 10mg, and the high blood plasma concentration by 54%. DISTRIBUTION Afinitor 10mg human plasma protein bound with the range of 74%.

  3. METABOLISM The metabolism of Everolimus is occurred in liver, which is a substrate of CYP3A4. The metabolites of Everolimus; Three monohydroxylated metabolite, Two hydrolytic rings opened products, & Phosphatidylcholine conjugate of Everolimus. EXCRETION The major route of elimination; 5% in urine; the parent compound has been detected in urine or feces. The half-life period of Everolimus is relatively 30 hours DOSAGE MANAGEMENT In breast cancer, renal cell cancer, pancreatic cancer, Neuro endocrine cancer: The prescribed dosage is 10mg should be taken as a single dose. In Brain or intracranial cancer: The prescribed dosage of Afinitor is 4.5mg/m2 orally as a single dose. In pediatric: The usual pediatric dosage of Afinitor in brain or intracranial tumor is 4.5mg/m2 should be taken orally as a single dose. Afinitor 10mg tablet should be administered with or without food.

  4. PRECAUTIONS Lymphomas: Increased exposure of skin cancers, patient may protect from UV light Serious infections: Patients receiving Afinitor 10mg have high risk of acquiring various infections related to bacteria, virus, and fungi. Anti-microbial agents are preferred for the suspected patients. Hepatic artery thrombosis: In liver transplant patients, Afinitor 10mg therapy should not be recommended. Nephrotoxicity: Renal function should be monitored frequently; caution should be taken while using Afinitor 10mg in renal impaired patients. Angioedema: This may have occurred in the patients receiving concomitantly Afinitor 10mg with Angiotensin converting enzyme agents Hyperlipidemia: Patient getting Afinitor 10mg tablet with lipid lowering drugs causes increasing in plasma concentration of these drugs causes hyperlipidemia Interstitial lung disease: Occurred in Afinitor 10mg therapy Interact with grape juice: Causes increasing blood levels of Everolimus; avoid these concomitants.

  5. SIDE EFFECTS • Hypersensitivity reactions • Lymphomas & other malignancy • Serious infections • Kidney graft thrombosis • Hepatic artery thrombosis • Nephrotoxicity • Hyperlipemia • Angioedema • Interstitial lung disease • Thrombocytopenia • Male infertility • Proteinuria • New commencement of diabetes . PREGNANCY: Pregnancy category C Afinitor 10mg is needed only by the patients after knowing the benefits to the mother outweighs the risk to fetus. LACTATION: Breast feeding should not be suggested STORAGE : Afinitor 10mg tablet should be kept at 25°C Keep the tablet away from moisture, heat and light Dispense only in original container

  6. MISSED DOSE: If patient failed to take a single dose, patients must consult with medical practitioner and follow the instructions given by them. Or the missed dose should be avoiding and follow the regular dosing schedule. OVERDOSAGE: The over dosage of Everolimus is rarely occur, in case of over dosage patient must be provide with supportive measures. The acute toxicity of Everolimus over dosage should be monitored. CONTACT US PHONE NO : +91-9940472902 EMAIL : millionhealthpharmaceuticals@gmail.com WEBSITE : https://millionpharma.com/everolimus-10mg.php

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