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Afinitor 10mgAfinitor 10mg - Anticancer drugs | view uses, side effects and price | MHP

Afinitor 10mg is a derivative of Rapamycin (sirolimus) and works similarly to Rapamycin as an mTOR (mammalian <br>target of rapamycin) inhibitor @ MHP

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Afinitor 10mgAfinitor 10mg - Anticancer drugs | view uses, side effects and price | MHP

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  1. AFFINITOR 10 MG | EVEROLIMUS 10MG | MILLIONHEALTHPHARMA

  2. DESCRIPTION

  3. Afinitor10mg is a derivative of Rapamycin (sirolimus) and works similarly to Rapamycin as an mTOR (mammalian target of rapamycin) inhibitor. • It is normally used as an immunosuppressant to prevent rejection of organ transplants. • In a similar fashion to other mTOR inhibitors Everolimus' effect is solely on the mTORC1 protein and not on the mTORC2 protein.

  4. Afinitor 10mg tablets are mainly indicated for the treatment of Renal carcinoma. • Afinitor 10mg tablets are mainly indicated for the treatment of Breast carcinoma. • Afinitor 10mg tablets are mainly indicated for the treatment of Brain carcinoma. • Afinitor 10mg tablet is also used in various advanced stage cancer in stomach, intestines or pancreas. PRESCRIBE INFORMATION

  5. Everolimus is an mTORprohibitor, joints at high compatibility to FK506 binding protein 12, via producing drug complex whichinhibits the specific of mTOR. • This inhibitiondecreases the activity of effectors downstream, that may cause blockage of cell progression from G1 into S phase, subsequently causes cell growth arrest and apoptosis MECHANISM OF ACTION

  6. The high plasma concentration time of Everolimus is 1 to 2 hours. • The effect of food with Afinitor 10mg that with heavy meal: Reduction of systemic exposure to Afinitor 5mg 10mg, and the high blood plasma concentration by 54%. ABSORPTION

  7. Afinitor10mg human plasma protein bound with the range of 74%. DISTRIBUTION

  8. The metabolism of Everolimus is occurred in liver, which is a substrate of CYP3A4. • The metabolites of Everolimus; • Three monohydroxylated metabolite, • Two hydrolytic rings opened products, & • Phosphatidylcholine conjugate of Everolimus. METABOLISM

  9. The major route of elimination; • 5% in urine; the parent compound has been detected in urine or feces. • The half-life period of Everolimus is relatively 30 hours EXCRETION

  10. In breast cancer, renal cell cancer, pancreatic cancer, Neuro endocrine cancer: • The prescribed dosage is 10mg should be taken as a single dose. • In Brain or intracranial cancer: • The prescribed dosage of Afinitor is 4.5mg/m2 orally as a single dose. DOSAGE MANAGEMENT

  11. In pediatric: • The usual pediatric dosage of Afinitor in brain or intracranial tumor is 4.5mg/m2 should be taken orally as a single dose. • Afinitor  10mg tablet should be administered with or without food.

  12. Lymphomas: • Increased exposure of skin cancers, patient may protect from UV light Serious infections: • Patients receiving Afinitor 10mg have high risk of acquiring various infections related to bacteria, virus, and fungi. Anti-microbial agents are preferred for the suspected patients. PRECAUTIONS

  13. Hepatic artery thrombosis:In liver transplant patients, Afinitor 10mg therapy should not be recommended. Nephrotoxicity: • Renal function should be monitored frequently; caution should be taken while using Afinitor 10mg in renal impaired patients. Angioedema: • This may have occurred in the patients receiving concomitantly Afinitor 10mg with Angiotensin converting enzyme agents

  14. Hyperlipidemia

  15. Hyperlipidemia: • Patient getting Afinitor 10mg tablet with lipid lowering drugs causes increasing in plasma concentration of these drugs causes hyperlipidemia • Interstitial lung disease: • Occurred in Afinitor 10mg therapy • Interact with grape juice: • Causes increasing blood levels of Everolimus; avoid these concomitants.

  16. Hypersensitivity reactions • Lymphomas & other malignancy • Serious infections • Kidney graft thrombosis • Hepatic artery thrombosis • Nephrotoxicity • Hyperlipemia SIDE EFFECTS

  17. Angioedema • Interstitial lung disease • Thrombocytopenia • Male infertility • Proteinuria • New commencement of diabetes .

  18. PREGNANCY: • Pregnancy category C Afinitor 10mg is needed only by the patients after knowing the benefits to the mother outweighs the risk to fetus. LACTATION: • Breast feeding should not be suggested STORAGE : • Afinitor 10mg tablet should be kept at 25°C • Keep the tablet away from moisture, heat and light • Dispense only in original container

  19. MISSED DOSE: • If patient failed to take a single dose, patients must consult with medical practitioner and follow the instructions given by them. • Or the missed dose should be avoiding and follow the regular dosing schedule. OVERDOSAGE: • The over dosage of Everolimus is rarely occur, in case of over dosage patient must be provide with supportive measures. The acute toxicity of Everolimus over dosage should be monitored.

  20. PHONE NO   : +91-9940472902 • EMAIL             : millionhealthpharmaceuticals@gmail.com  • WEBSITE      :  https://millionpharma.com/everolimus-10mg.php CONTACT US

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