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Introduction. Marked increase in Alkaline Phosphatase . Normalises within around 12 weeks. Incidental finding but often raised to an alarming level. Increase in both liver and bone fractions. Benign
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1. Benign Transient Hyperphosphatasaemia Lynn Rowbottom
January 2007
3. Suggested causes Increased activity of normal amount of enzyme
4. Seasonal presentation
5. Suggested causes Enzyme release from tissues
6. 3 suspected BTH cases Randomly identified
7. Case 1: Male DOB:17/10/03Jaundiced ? Hep A
8. Case 1 ALP Electrophoresis
9. Case 2: Female DOB:17/07/04Bony lump on chest and alk phos high
10. Case 2 Isoenzyme Electrophoresis
11. Case 3: Male DOB: 07/03/05Bruising. URTI?
13. Summary
15. Conclusion Be aware of BTH in children AND adults
Benign and transient
Unusual sialoforms may prove useful in the diagnosis of this condition
? ALP in acute phase response
16. Acknowledgements Christopher Reeves, Katharine Hayden & Ian Watson, University Hospital Aintree
Elaine Kerr, Alder Hey Childrens Hospital
Andrew Davison & Tony Stott, Royal Liverpool University Hospital
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