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  1. Insulinoterapia Carrera de Enfermería Farmacología 17 de mayo 2010 Terapia Farmacológica en Diabetes Mellitus EU-Lic. Rene Castillo Flores Unidad de Fisiología y Farmacología Universidad Santo Tomás Sede Temuco - Chile

  2. Historia • 1921, Los fisiólogos canadienses Frederick G. Banting y Charles H. Best extrajeron por primera vez la insulina del tejido pancreático de los perros.

  3. Historia • 1922, administraron 15 ml de insulina exógena a un paciente diabético Leonard Thompson y su glicemia disminuyó de 440 a 320 mg/dL. • 1923 Premio Nóbel de Medicina descubrimiento de la insulina, MacLeod y Banting.

  4. Década 50 Insulina lenta Década 40 Protamina Neutra Hagedorn (NPH) Década 30 Insulina Protamina Zinc (PZI), Historia

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