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Pharmacokinetics, Overview

Absorption: It is the process of entry of drug from site of administration into systemic circulation.Drug should be at an adequate concentration at its site of action to produce its effect The two fundamental processes that determine the concentration of a drug at any moment and in any region of t

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Pharmacokinetics, Overview

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    2. Absorption: It is the process of entry of drug from site of administration into systemic circulation. Drug should be at an adequate concentration at its site of action to produce its effect The two fundamental processes that determine the concentration of a drug at any moment and in any region of the body are: translocation of drug molecules chemical transformation by drug metabolism and other processes involved in drug elimination These are critically important for choosing appropriate routes of administration

    7. In the terminal ileum, the cobalamin-intrinsic factor complex binds to specific receptors on the mucosal brush border. In the mucosal cells, the cobalamin-intrinsic factor complex bound to receptor undergoes pinocytosis. The intrinsic factor is degraded, and cobalamin is transferred to transcobalamin-II and released into the circulation as holo transcobalamin. In the terminal ileum, the cobalamin-intrinsic factor complex binds to specific receptors on the mucosal brush border. In the mucosal cells, the cobalamin-intrinsic factor complex bound to receptor undergoes pinocytosis. The intrinsic factor is degraded, and cobalamin is transferred to transcobalamin-II and released into the circulation as holo transcobalamin.

    14. 2-Distribution

    15. Drugs in vascular space

    16. 3-Biotransformation (Metabolism)

    17. 4- Excretion of drugs

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