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NIH: A Time of Unprecedented Opportunity Senate Appropriations Subcommittee on Labor/HHS/Education Elias A. Zerhouni, M.

NIH: A Time of Unprecedented Opportunity Senate Appropriations Subcommittee on Labor/HHS/Education Elias A. Zerhouni, M.D. Director. The Future Paradigm: The 4 P’s Transform Medicine from Curative to Preemptive. Personalized. Predictive. Preemptive. Participatory. A. B. C. D. E.

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NIH: A Time of Unprecedented Opportunity Senate Appropriations Subcommittee on Labor/HHS/Education Elias A. Zerhouni, M.

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  1. NIH: A Time of Unprecedented Opportunity Senate Appropriations Subcommittee on Labor/HHS/Education Elias A. Zerhouni, M.D. Director

  2. The Future Paradigm: The 4 P’sTransform Medicine from Curative to Preemptive Personalized Predictive Preemptive Participatory

  3. A B C D E Normal Gene FunctionHealthy State A E B C D

  4. A B C C C D E Disrupted Gene FunctionDisease State A A B E B C D D E

  5. C C C C D Disrupted Gene FunctionDisease State A A E A B E B C D D E

  6. Toward a New Era in Medicine: Genome-wide Association Discoveries 2007 second quarter 2007 third quarter 2008 first quarter 2007 first quarter 2007 fourth quarter 2006 2005 Type 2 Diabetes 10 years ago: 0 genes 5 years ago: 2 genes Today: 16 genes Autism Last week: 6 new genes discovered Second quarter 2008 Manolio, Brooks, Collins, J Clin Invest 2008; 118:1590-625. .

  7. Opportunities in Cancer Research: New Genomic Clues Goal: To systematically explore the entire spectrum of genomic changes involved in human cancer Current study: Lung, glioblastoma, and ovarian cancers Finding: Three new genes discovered mutated in glioblastoma Glioblastoma Credit: Arthur Toga/UCLA/Photo Researchers Inc.

  8. What Are the Next Steps? How Do Scientists Unravel the Mystery? Initial Genome-Wide Association Study Clues Analyzing More Populations and More Genes Leads Understanding the Biology Targets Translation Diagnostics Therapeutics Prevention Strategies

  9. Transforming medicine and health through discovery NIH

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