Echemi Chemical 4-Bromo-2-methyl-6-nitroaniline Description

1. CAS No:77811-44-0 Formula:C7H7BrN2O2 Synonyms:4-BROMO-6-NITRO-O-TOLUIDINE;4-BROMO-2-METHYL-6-NITROANILINE;4-BROMO-2- METHYL-6-NITRO-PHENYLAMINE;2-Nitro-4-bromo-6-methylaniline;4-Bromo-2-methyl-6-nitroben zenamine;4-broMo-2-Methyl-6-nitroanilin;2-Amino-5-bromo-3-nitrotoluene, 2-Amino-5-bromo-3-methylnitrobenzene, 4-broMo-2-Methyl-6-nitro- China Export:From 2018.11 to 2019.11, total export volume of 4-Bromo-2-methyl-6-nitroaniline from China was 86,064,641KG while total export value was $180,130,186. The biggest proportion of exporting volume in the last 12 months was 14.15% in 2019.11. 4-Bromo-6-nitro-o-toulidine;BenzenaMine, Echemi Chemical 4-Bromo-2-methyl-6-nitroaniline Description orange to orange-brown glistening crystals Echemi Chemical 4-Bromo-2-methyl-6-nitroaniline Basic Attributes CAS No：77811-44-0 Molecular Formula ：C7H7BrN2O2 Molecular Mass ：231.05 Exact Mass ：229.969086 PSA ：71.8 A^2 LogP ：2.7 EINECS ：616-508-6 InChIKeys ：ZXFVKFUXKFPUQJ-UHFFFAOYSA-N H-bond Acceptor ：3 H-bond Donor ：1 SP3 ：0.14 RBN ：0 Echemi Chemical 4-Bromo-2-methyl-6-nitroaniline Characteristics Density ：1.7±0.1 g/cm3 Melting Point ：143-147 °C

2. Flash Point ：151.4±26.5 °C Refractive Index ：1.649 Solubility ：Slightly soluble in water and soluble in hot methanol. Echemi Chemical 4-Bromo-2-methyl-6-nitroaniline Safety Information Hazard Class ：IRRITANT HS Code ：29214200 UN No. ：NONH for all modes of transport WGK_Germany ：3 Risk Code ：36/37/38-20/21/22 Safety Instructions ：26-36/37 Dangerous Mark ：Xi,Xn P Code ：P261-P280-P305 + P351 + P338 Hazard Statements ：H312-H315-H319-H332-H335 Hazard Note ：Harmful Echemi Chemical 4-Bromo-2-methyl-6-nitroaniline Production Methods

3. Starting material 20a (1.00 g, 4.32 mmol) was dissolved in 15 mL of AcOH.An aqueous solution (2 mL) of sodium nitrite (0.66 mg, 9.52 mmol) was added at 0 C.After the addition, rt was stirred for 6 hours.The TLC monitors the reaction of the starting material completely, spins the reaction solution, extracts, and the crude product is purified by column chromatography.An orange powder compound 20b (0.5 mg, 2.07 mmol) was obtained in a yield: 47.7%.Starting material 10 (1.00 g, 4.32 mmol) was dissolved in 15 mL of AcOH. An aqueous solution (2 mL) of sodium nitrite (0.66 mg, 9.52 mmol) was added at 0 C. After the addition, rt was stirred for 6 hours. TLC monitors the reaction of the starting material completely, spins the reaction solution, and extracts. The crude product was purified by column chromatography. Obtained an orange powder compound 2 (0.5 mg, 2.07 mmol), Yield: 47.7%.Starting material 10 (1.00 g, 4.32 mmol) was dissolved in 15 mL of AcOH.An aqueous solution (2 mL) of sodium nitrite (0.66 mg, 9.52 mmol) was added at 0 C. After the addition, rt was stirred for 6 hours.The reaction of the starting material was completed by TLC, and the reaction mixture was evaporated to dryness, and the crude product was purified by column chromatography to afford compound (0.5 mg, 2.07 mmol), yield: 47.7%.Example 7 N4 -((7-methyl-lH-benzo[d]imidazol-5-yl)methyl)-pyrimidine-2, 4- diamine (1-26) step 1 : To a suspension of 5-Bromo-3-methyl-benzene-1, 2-diamine: To a suspension of To a suspension of a 5-Bromo-2.3-diamino-toluene A solution of 15 g (64.9 mmol) of Example 4 1- (2-Cyclopropyl-l, 4-dimethyl-lH-benzimidazol-6-yl ) -4- ( (4- fluorobenzyl) oxy) pyridin-2 ( 1H) -one A) 5-Bromo-3-methylbenzene-l, 2-diamine To a stirred solution of compound 4-bromo-2-methyl-6- nitroaniline (5.0 g) in EtOH (85 ml) and water (43 ml) were added iron powder (6.0 g) and CaCl2 (4.8 g) at room temperature and the resulting reaction mixture was then heated at reflux for 4 h. The mixture was then cooled to room temperature, filtered through Celite, and washed with EtOH. The filtrate ' was concentrated and the resulting residue was diluted with DCM. The DCM layer was successively washed with water and brine, dried over Na2S04 and concentrated in vacuo to give the title compound (4.0 g) as a dark brown solid. MS (ESI+) : [M+H]+ 201.2.a 5-Bromo-2, 3-diaminotoluene A solution of 15 g (64.9 mmol) of Celite powder (38.0 g) and iron powder (27.6 g) wereadded to a mixture of -(5-Cyclopropyl-lH-pyrazol-3-yl)- N2