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Viral Inhibition of the Anaphase-Promoting Complex/Cyclosome as a Mechanism of Tumor-specific Cell Death Jose G. Teodoro

Viral Inhibition of the Anaphase-Promoting Complex/Cyclosome as a Mechanism of Tumor-specific Cell Death Jose G. Teodoro, Ph.D McGill Cancer Center Department of Biochemistry McGill University Montr é al , Canada. Viruses as tools in the study of cell transformation and apoptosis.

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Viral Inhibition of the Anaphase-Promoting Complex/Cyclosome as a Mechanism of Tumor-specific Cell Death Jose G. Teodoro

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  1. Viral Inhibition of the Anaphase-Promoting Complex/Cyclosome as a Mechanism of Tumor-specific Cell Death Jose G. Teodoro, Ph.D McGill Cancer Center Department of Biochemistry McGill University Montréal, Canada

  2. Viruses as tools in the study of cell transformation and apoptosis

  3. Viruses as tools in the study of cell transformation and apoptosis

  4. Apoptin localizes in a transformation-dependent manner

  5. Apoptin localization is regulated by a factor in transformed cells

  6. Proteomic analysis of Apoptin-associated proteins

  7. Subunit structure of the APC/C Thornton et al. Genes & Dev (2006)

  8. Apoptin induces destabilization of the APC/C FPLC analysis

  9. Apoptin colocalizes with APC/C within PML bodies

  10. Apoptin colocalizes with APC/C within PML bodies

  11. Tran et al. J Virol. 2007 Oct 17

  12. Overview and future directions How does G2/M arrest proceed to apoptosis? Do current chemotherapies rely on APC/C inhibition for efficacy? Can the APC/C be an anti-cancer drug target?

  13. Acknowledgements McGill University Isabelle Gamache Mohamed Mustafa Russell Towers Sarah Assadian Yiqing Lu Michael Hell U Mass Michael Green Destin Heilman Albert Parker Julie Zhou Reagents Frank Graham Crister Hoog

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