1 / 28

Andvord K F. Norsk Magasin for Lægevidenskapen 1930;91:642-60

Kristian Andvord’s break-through observation. Andvord K F. Norsk Magasin for Lægevidenskapen 1930;91:642-60. The “Koch Phenomenon”. A primary infection leads to a delayed response and has often a mild and self-limited course

agamemnon-elena
Télécharger la présentation

Andvord K F. Norsk Magasin for Lægevidenskapen 1930;91:642-60

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Kristian Andvord’s break-through observation Andvord K F. Norsk Magasin for Lægevidenskapen 1930;91:642-60

  2. The “Koch Phenomenon” A primary infection leads to a delayed response and has often a mild and self-limited course A reinfection results commonly in a rapid response with tissue necrosis Drawings: Koch R. Mittheilungen aus dem Kaiserlichen Gesundheitsamte 1884;2:1-88. Phenomenon: Koch R. Dtsch Med Wochenschr 1891;17:101-2.

  3. Andvord Canetti Re-infection Morbidity / mortality Remaining live bacilli Birth cohort Primary infection Cross-sectional A B Age Time / age Koch BMRC BCG Trial Progressive Re-infection Abortive Tissue destruction BCG protection Primary infection C D Time Time

  4. Effect of Environmental Mycobacteria: Blocking and Masking Hypothesis Andersen P, et al. Nature Rev 2005;3:656-62

  5. …and another research question: If an individual is not protected by BCG, is tuberculosis more severe in this individual?

  6. Operating Characteristics of IGRAs Pai M, et al. Expert Rev Mal Diagn 2006;6:413-22

  7. Thank you for your attention and patience

More Related