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Vesicle Transport

Chapter 13. Vesicle Transport. Multivesicular bodies form on the pathway to late endosomes. ubiquitin marks protein for destruction. Formation of secretory vesicles. Blood glucose regulation. α and β cells in islet of Langerhans. The Pancreas.

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Vesicle Transport

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  1. Chapter 13 Vesicle Transport

  2. Multivesicular bodies form on the pathway to late endosomes

  3. ubiquitin marks protein for destruction

  4. Formation of secretory vesicles

  5. Blood glucose regulation

  6. α and β cells in islet of Langerhans

  7. The Pancreas

  8. Secretory vesicles formed in a insulin secreting β cell of the pancreas stained with clathrin antibody

  9. Release of insulin from a secretory vesicle of a pancreatic β-cell

  10. Insulin signal causes relocation of glucose transporters

  11. Before Insulin • Before insulin was discovered in 1921, everyone with type 1 diabetes died within weeks to years of its onset

  12. rapid histamine release by mast cells

  13. chapter 15 Cell Communication

  14. Intracellular signaling pathways

  15. 4 types of intercellular signaling

  16. 4 types of intercellular signaling

  17. Autocrine signaling allow a group of cells but not a single cell to respond to a differentiation signal coordinates decisions by a group of identical cells

  18. Gap junctions allow signaling information to be shared by neighboring cells

  19. figure 05-06b.jpg Gap Junction

  20. An animal cell depends on extracellular signals to survive or divide

  21. An animal cell depends on extracellular signals to differentiate. Without extracellular signals the cell will die

  22. Acetylcholine, a neurotransmitter, can induce various responses in different cells

  23. Acetylcholine, a neurotransmitter, can induce various responses in different cells

  24. Acetylcholine, a neurotransmitter, can induce various responses in different cells

  25. Chemical Structure of Acetylcholine

  26. Signaling molecules must be turned over rapidly; if turnover time is one minute concentration can decrease rapidly

  27. Signaling molecules must be turned over rapidly; if turnover time is one minute concentration can increase rapidly

  28. Extracellular signaling molecules can bind to intracellular receptors

  29. Acetyl choline causes release of NO which results in rapid relaxation of smooth muscle cells

  30. Signaling molecules that bind to nuclear receptors are small and hydrophobic

  31. Inhibitory proteins make receptor inactive when not bound to the signaling molecule

  32. When signaling molecule binds receptor binds DNA and increases gene transcription

  33. Nuclear receptors have a DNA binding domain

  34. Extracellular signaling molecules can bind to cell surface receptors

  35. 3 large classes of cell surface receptors; ion channel linked receptors

  36. Active Chemical Synapse

  37. 3 large classes of cell surface receptors; G protein linked receptors

  38. 3 large classes of cell surface receptors; enzyme linked receptors

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