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Regulation of BP

Regulation of BP. Rene Kosi School of Medicine, 2nd year 2013/2014 Mentor: A. Žmegač Horvat. What is BP?. Force exerted by blood against any unit area of the vessel wall Heartbeat -> systolic -> diastolic. How do we measure it?. Auscultatory method.

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Regulation of BP

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  1. Regulation of BP Rene Kosi School of Medicine, 2nd year 2013/2014 Mentor: A. Žmegač Horvat

  2. What is BP? • Forceexertedbybloodagainstanyunitareaofthevesselwall • Heartbeat -> systolic -> diastolic

  3. How do we measure it? • Auscultatory method

  4. Measured in millimeters of mercury (mm Hg)

  5. So, how does our body control BP? • 2 mechanisms: • Short-term regulation • Long-term regulation

  6. Short-term regulation • Negative feedback reflex mechanisms • 1) Baroreceptor reflexes • Stimulated when stretched • Signals to tractus solitarius in medulla • Respond to rapid changes of pressure

  7. 2) Circulatory reflex • Inhibit the vasoconstrictor center • Excite the vagal parasympathetic center • Vasodilatation • Decreased heart rate

  8. Baroreceptor control = pressure buffer control

  9. Long-term regulation • If blood volume increases and vascular capacitance is not altered, arterial pressure will also increase • Pressure diuresis

  10. Near Infinite Feedback Gain • Until the pressure returns exactly to the equilibrium point

  11. Increase in salt intake: • Stimulates thirst center in the brain • Increased secretion of ADH • Pressure natriuresis

  12. Renin-Angiotensin System

  13. Sources: • Guyton and Hall Textbook of Medical Physiology, 12th edition, 2012 • Me 

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