1 / 35

Non-Hodgkin Lymphoma

Non-Hodgkin Lymphoma. Dr. Raid Jastania Dec 2006. By the end of this session you should be able to: Classify Non-Hodgkin lymphoma

alodie
Télécharger la présentation

Non-Hodgkin Lymphoma

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Non-Hodgkin Lymphoma Dr. Raid Jastania Dec 2006

  2. By the end of this session you should be able to: • Classify Non-Hodgkin lymphoma • Know the clinical and pathological features of common Non-Hodgkin B-cell lymphomas (ALL, CLL, Mantle cell lymphoma, Follicular lymphoma, Marginal zone lymphoma, DLBCL, and Burkitt lymphoma)

  3. Classification of Non-Hodgkin Lymphoma

  4. Precursor B cell Acute lymphoblastic lymphoma Peripheral B cell Small lymphocytic lymphoma SLL, Chronic lymphocytic leukemia CLL Mantle cell lymphoma Follicular lymphoma Marginal zone lymphoma Diffuse large B cell lymphom Burkitt lymphoma Precursor T cell Acute lymphoblastic lymphoma Peripheral T cell Anaplastic large T cell lymphoma Peripheral T cell lymphoma Classification of Non-Hodgkin Lymphoma (selected common entities)

  5. B cell • Precursor Naïve Mantle Germinal center Marginal zone Morphology • Blast Small mature Large transformed plasma cell Markers • CD34/TdT CD5 CD20/CD10 CD20 only Homing • BM Peripheral LN LN/extralymphatic Symptoms • BM suppression Leukemia LN involve mass Patterns

  6. Acute lymphoblastic lymphoma/leukemia (ALL) • Clinical: children, young adults, leukemic, mediastianl mass (T cell ALL), Bone marrow involvement, high grade • Pathology: medium size Blasts, uniform • Immuno: TdT, CD 34, CD10, (CD20 or CD3)

  7. Small lymphocytic lymphoma SLL, Chronic lymphocytic leukemia CLL • Clinical: low grade, asymptomatic, nodal and leukemic, elderly 7th, 8th decade • Pathology: small cells, vague nodularity, proliferation centers • Immuno: CD20, CD23, CD5 • Can transform to large cell lymphoma (Richter transformation)

  8. Mantle cell lymphoma • Clinical: Variable (low grade to aggressive) >50 year, nodal, GI tract • Pathology: small uniform cells • Immuno: CD20, CD5, CyclinD1 • T(11;14) cyclinD1 • Transformation to large cell lymphoma is very rare

  9. Follicular lymphoma • Clinical: Low grade, Nodal, > 40 years • Pathology: large malignant follicles, mixture of small (centrocytes) and large cells (centroblasts) • Immuno: CD20, CD10, Bcl-2 • T(14;18) Bcl-2 over expression • 30% transform to large cell lymphoma

  10. Marginal zone lymphoma • Clinical: nodal or extranodal (MALT), low grade • Pathology: mixture of small, large lymphocytes and plasma cells • Immuno: CD20 only • Can transform to large cell lymphoma • Treatment

  11. Diffuse large B-cell lymphoma • Heterogenous group: Denovo, or transformed low grade lymphoma (FL) • Nodal or extranodal, Intermediate grade • Pathology: Sheets of large cells, mitosis, apoptosis • Immuno: CD20, most CD10+

  12. Burkitt lymphoma • Clinical: 3 types • 1. Endemic: African EBV • 2. Sporadic: North America • 3. Immunosuppressed (HIV) • Aggressive tumor • Pathology: medium size, high mitosis, apoptosis, Starry sky pattern • Immuno: CD20, CD10 • T(8;14) C-myc over expression

  13. Test

More Related