Nanomilling: How Altasciences Can Help Improve Solubility and Bioavailability

1. Nanomilling: How Altasciences Can Help Improve Solubility and Bioavailability

2. Nanomilling: How Altasciences Can Help Improve Solubility and Bioavailability One of the most crucial features of drug development is bioavailability. This is the ability for a drug to be absorbed and used by the body. To be bioavailable, the drug needs to be soluble or able to dissolve, especially in water. Many drugs currently on the market are not very water- soluble, which opens up the opportunity for formulation improvements through nanomilling. Altasciences, an integrated CRO/CDMO, can provide bioanalysis and nanomilling services to help determine and improve the solubility of your drug. Here’s everything you need to know. Solubility Challenges It’s not unheard of that therapeutic molecules classified as “poorly soluble” inearly clinical development can still be successfully developed. Some technologies can increase solubility and oral bioavailability in poorly soluble molecules. This is achieved by reducing the particle size of the active pharmaceutical ingredients. Nearly any API with water solubility below 200 µg/mL can be nanomilled. It’s a very adaptable drug delivery platform suitable for injectable, inhalable, oral, and buccal applications.

3. Benefits to Nanomilling Decreasing the API size means more surface area, which increases the API’s dissolution rate and bioavailability. For the parenteral route, this means small dose volumes are best due to high drug loading. It also means avoiding the use of harsh solvents or extreme pH conditions. It can also enable the use of inhalers for the pulmonary route and spray-dried powders optimized for deep lung delivery. It also results in faster therapeutic effects, low excipient side effects, reduced fed/fasted variability in both solid and liquid dosage forms, and can run continuously. Is Nanomilling Right for Your Drug? Nanomilling physically breaks down coarse particles using a high-energy wet mill. This reduces the size to less than 1,000 nm, often in the 100 to 200 nm range. It’s a very efficient technique, and milling time may only be minutes with a modern mill. Selecting the optimal stabilizer formulation and process/equipment framework for a wet media milling process is essential for manufacturing a drug nanosuspension with the desired particle size. Otherwise, there can later be problems with the manufacturing process. This can result in poor product performance or slow dissolution in final dosages. Altasciences Has Experience You Can Trust Because nanomilling is a highly complex process, it requires a unique level of pharmaceutical CDMO capabilities and expertise. The experts at Altasciences have the necessary experience to take your API from formulation to first in human clinical trials, through to commercialization. Altasciences has the necessary procedures and equipment to work with any formulation. Their highly skilled, experienced teams work with the latest technology and equipment, producing particles to nanometer size with wet milling options. They can also fill vials in a range of sizes, from 0.3 ml to 500 ml, and package them. Partner with Altasciences for nanomilling capabilities at https://www.altasciences.com/ Original Source: https://bit.ly/3L3F0mB