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An unattended finding: associations of agricultural airborne pesticide vapors

An unattended finding: associations of agricultural airborne pesticide vapors attaining inhabited areas with respiratory symptoms of 7–11 years old children in Heves county, Hungary M. J. Varró 1 , Z. Virágh 1 , Gy. Gombkötõ 2 , M. Szeremi 2 , P. Rudnai 1

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An unattended finding: associations of agricultural airborne pesticide vapors

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  1. An unattended finding: associations of agricultural airborne pesticide vapors attaining inhabited areas with respiratory symptoms of 7–11 years old children in Heves county, Hungary M. J. Varró1, Z. Virágh1, Gy. Gombkötõ2, M. Szeremi2, P. Rudnai1 1Fodor József National Center for Public Health, National Institute of Environmental Health; Budapest, Hungary; 2National Public Health and Medical Officer Service,Institute of Heves County; Eger, Hungary NCPH NIEH NPHMOS

  2. INTRODUCTION 1. Nat. Inst. Environ. Health Fodor József Nat. Center Publ. Health, (formerly: Nat. Inst. Hyg.,) Budapest, Hungary Nat. Publ. Health & Med. Officer Service series of highly uniform environmental epidemiologic surveys among 7–11 y children NCPH NIEH NPHMOS

  3. INTRODUCTION 2. 1995/96CESAR - international survey - 5 towns, N=3720 - questionnaire - physical examination - spirometry - measures of outdoor air pollutants NCPH NIEH NPHMOS

  4. INTRODUCTION 2. Questionnaire - health endpoints - indoor environmental factors - other influencing factors Main finding - respiratory symptoms & yearly average cc PM NCPH NIEH NPHMOS

  5. INTRODUCTION 3. 1997 12 towns, N=6221 1998 6 towns, N=1768 1999 3 towns, N=1579 2000 6 counties, N=2354 2001 Heves county, N=2540 2002 Budapest 2 distr.+1 suburban, N=567 NCPH NIEH NPHMOS

  6. INTRODUCTION 4. ... arised: agricultural airborne pesticide sprays do attain inhabited areas (no report) Highly significant associations with health endpoints NCPH NIEH NPHMOS

  7. OBJECTIVE To evaluate the associations of pesticide sprays with respiratory symptoms - of 7–11 year old children - in 40 villages of an area of Heves county - in 2001 NCPH NIEH NPHMOS

  8. METHODS 1. Allergic symptoms - house dust - pollen - animal hair, feather - food - medicine - other - diagnosis: by a doctor? NCPH NIEH NPHMOS

  9. METHODS 2. Neurotic symptoms: at least two of - lack of appetite - fatigue - headache - irritability - anxiety NCPH NIEH NPHMOS

  10. METHODS 3. Head mucosal symptoms: at least one of - conjunctivitis - blocked nose - sinusitic complaints - earache NCPH NIEH NPHMOS

  11. METHODS 4. Bronchitic symptoms regular cough - in autumn-winter - mornings - days/nights - daily, >3 months - with sputum NCPH NIEH NPHMOS

  12. METHODS 5. Asthmatic symptoms - in the last 12 months - wheezing - dry cough at night - asthma - ever diagnosed by a doctor NCPH NIEH NPHMOS

  13. METHODS 6. Data entry, - procession - Epi Info 6.04d Analysis - STATA 7.0 - bivariate tabulation - backward logistic models NCPH NIEH NPHMOS

  14. N0=2437 N=1819 74.6% Reported symptoms 1. 7–11 years old children, Villages, Heves county, Hungary, 2001 % 50 21.8 20.3 25 0 Allergic symptoms Min. 2 neur. sy.-s N=1718 N=1647 NCPH NIEH NPHMOS

  15. Reported symptoms 2. 7–11 years old children, Villages, Heves county, Hungary, 2001 % 50 46.3 25 15.5 14.1 0 Head mucosal Bronchitic Asthmatic N=1647 N=1623 N=1471 NCPH NIEH NPHMOS

  16. Agricultural airborne pesticide sprays attaining inhabited areas Villages, Heves county, Hungary, 2001 82.5% of the villages (n=40) % 100 90.8 75 50 25 9.2 0 No sprays Sprays N=1666 NCPH NIEH NPHMOS

  17. Agricultural airborne pesticide sprays attaining inhabited areas Villages, Heves county, Hungary, 2001 % 100 86.1 OR=2.48*** (95% CI= 1.76–3.44) 93.9 75 50 13.9 25 6.1 0 Vineyard territories General agricultural N=1013 N=653 Sprays No sprays NCPH NIEH NPHMOS

  18. Agricultural airborne pesticide sprays/ inhabited areas and allergic symptoms 7–11 years old children, Villages, Heves county, Hungary, 2001 % 75 OR=2.13*** (95% CI=1.48–3.07) mOR=2.23*** (95% CI=1.48–3.37) goodness-of-fit: p=0.69 50 25 34.9 20.1 0 No sprays Sprays N=1451 N=146 NCPH NIEH NPHMOS

  19. Agricultural airborne pesticide sprays/ inhabited areas and neurotic symptoms 7–11 years old children, Villages, Heves county, Hungary, 2001 % 75 OR=2.19*** (95% CI=1.51–3.17) mOR=2.33*** (95% CI=1.55–3.51) goodness-of-fit: p=0.18 50 25 33.3 18.6 0 No sprays Sprays N=1391 N=144 NCPH NIEH NPHMOS

  20. Agricultural airborne pesticide sprays/ inhabited areas and head mucosal sy.-s 7–11 years old children, Villages, Heves county, Hungary, 2001 % 75 OR=1.51* (95% CI=1.08–2.14) 50 55.6 45.1 25 0 No sprays Sprays N=1391 N=144 NCPH NIEH NPHMOS

  21. Agricultural airborne pesticide sprays/ inhabited areas and bronchitic sy.-s 7–11 years old children, Villages, Heves county, Hungary, 2001 % 75 OR=1.93** (95% CI=1.28–2.92) 50 24.6 25 14.5 0 No sprays Sprays N=1382 N=138 NCPH NIEH NPHMOS

  22. Agricultural airborne pesticide sprays/ inhabited areas and asthmatic sy.-s7–11 years old children, Villages, Heves county, Hungary, 2001 % 75 OR=1.82** (95% CI=1.20–2.78) 50 21.9 25 13.3 0 No sprays Sprays N=1450 N=146 NCPH NIEH NPHMOS

  23. DISCUSSION 1. Whether it is really possible? - to check retrospectively - flight documentations - to check prospectively - biological monitoring NCPH NIEH NPHMOS

  24. DISCUSSION 2. Chance - high p-values! Bias - recall bias? Confounding - not probable NCPH NIEH NPHMOS

  25. SUMMARY 1. - Pesticide sprays do attain inhabited areas - Respiratory symptoms - 7–11 y children - N=1819 survey questionnaires NCPH NIEH NPHMOS

  26. SUMMARY 2. - allergic and neurotic symptoms - prevalences: 21.8%, 20.3% - pesticide sprays attaining inhabited areas: 9% - odds ratios: 2.13*** (2.23***), 2.19*** (2.33***) NCPH NIEH NPHMOS

  27. SUMMARY 3. - head mucosal, bronchitic, asthmatic sy.-s - prevalences: 46.3%, 15.5%, 14.1% - odds ratios: 1.51*, 1.93**, 1.82* NCPH NIEH NPHMOS

  28. CONCLUSION Specially designed investigations - environmental health impact - pesticide spraying Official measures NCPH NIEH NPHMOS

  29. THANKS HUNGARIAN NEHAP SECRETARY Dr. Anna Páldy „Fodor József” NCPH NIEH DEPT. COMMUNITY HEALTH Annamária Mácsik, Tamás Rudnai, Eszter Szabó, Renáta Szentmihályi, Györgyi Tóth SCHOOLS, MUNICIPALITIES, HEALTH SERVICESdirectorship of schools, class leaders, maires, youth and district nurses FAMILIES parents, children NCPH NIEH NPHMOS

  30. Thanks for the attention NCPH NIEH NPHMOS

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