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DNA Damage Response

Phenotype. Targeted. DNA Damage Response. Tissues. Mutation. Survival. Intercellular Signaling. Non-Targeted. Targeted vs Non-Targeted Radiation Effects. Targeted effects are proportional to radiation dose, e.g. cell kill

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DNA Damage Response

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  1. Phenotype Targeted DNA Damage Response Tissues Mutation Survival Intercellular Signaling Non-Targeted

  2. Targeted vs Non-Targeted Radiation Effects • Targeted effects are proportional to radiation dose, e.g. cell kill • The dose dependence of non-targeted effects are more like switches rather than rheostats • Both contribute to cancer risk

  3. What is the Utility of Incorporating NTE into Risk Paradigms? • NTE are the mechanistic basis of non-cancer health effects • Necessary for the biological veracity of LNT at low dose/dose rate where epidemiological data are uncertain • May identify susceptible populations • Could provide avenues for protection after radiation exposure

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