1 / 22

Defining Robust Biomarker Profiles

Defining Robust Biomarker Profiles. A: The “Matrix”. By generating the Matrix from different sample sizes we demonstrate the power of sample size (N).

amethyst-fry
Télécharger la présentation

Defining Robust Biomarker Profiles

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Defining Robust Biomarker Profiles A: The “Matrix” By generating the Matrix from different sample sizes we demonstrate the power of sample size (N). The matrix is made up of over 1.4 million correlations. The level of variation in these correlations for different sample sizes by random sampling using a Monte-Carlo Method is:. Sample Size St Dev of Correlation Coefficient N=20 .220 (high/variable correlations) N=50 .137 N=100 .092 N=200 .061 N=500 .035 N=1000 .014 (stable and biol plausible) Significance levels take into account sample size to control the levels of error above for 1 analysis at a time. However, when we are looking for patterns amongst variables, the stability of thelarge sample is absolutely necessary. The above test demonstrates that 99% of the values in our matrix fall within .05 of the ‘true’ population value (based on asymptotics).

  2. N=20 N=50 N=200 N=1000

  3. N=20 N=50 N=200 N=1000

  4. N=20 N=50 N=200 N=1000

  5. N=20 N=50 N=200 N=1000

  6. N=20 N=50 N=200 N=1000

  7. N=20 N=50 N=200 N=1000

  8. N=20 N=50 N=200 N=1000

  9. N=20 N=50 N=200 N=1000

  10. N=20 N=50 N=200 N=1000

  11. N=20 N=50 N=200 N=1000

  12. N=20 N=50 N=200 N=1000

  13. N=20 N=50 N=200 N=1000

  14. N=20 N=50 N=200 N=1000

  15. N=20 N=50 N=200 N=1000

  16. N=20 N=50 N=200 N=1000

  17. N=20 N=50 N=200 N=1000

  18. N=20 N=50 N=200 N=1000

  19. N=20 N=50 N=200 N=1000

  20. N=20 N=50 N=200 N=1000

  21. N=20 N=50 N=200 N=1000

  22. N=20 N=50 N=200 N=1000

More Related