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Malignant Nephroblastoma in a Horse

Elizabeth M. Whitley, DVM, PhD, Dipl. ACVP 1 Isabel Hurtado Rodriguez, DVM, MS, Dipl. ACVIM 2 Amelia S. Munsterman , DVM, MS, Dipl. ACVS 2 1 Department of Pathobiology 2 Department of Clinical Sciences College of Veterinary Medicine Auburn University.

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Malignant Nephroblastoma in a Horse

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  1. Elizabeth M. Whitley, DVM, PhD, Dipl. ACVP1 Isabel Hurtado Rodriguez, DVM, MS, Dipl. ACVIM2 Amelia S. Munsterman, DVM, MS, Dipl. ACVS2 1Department of Pathobiology 2Department of Clinical Sciences College of Veterinary Medicine Auburn University Malignant Nephroblastoma in a Horse Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only www.sogonow.com/archives/2007/01/07-week/

  2. Signalment • 5-year-old, male castrated, American quarter horse • Used for roping • Recent, intermittent reluctance to work on the right hand • Recent, unexplained weight loss Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only www.sogonow.com/archives/2007/01/07-week/

  3. Clinical Work-up • Presented for colic that was non-responsive to Banamine and sedation • Clinical signs: • Dehydration, tachycardia, tachypnea • Copious nasogastric reflux when tubed • Distended small intestine on ultrasound and palpation • Diagnosed a renal mass on ultrasound Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  4. Nephroblastoma Rare neoplasm in animals other than pigs or chickens Usually observed in young animals “Wilms’ tumor” in children Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only http://www.nlm.nih.gov/medlineplus/ency/imagepages/9056.htm

  5. Nephroblastoma • Three different morphologies • Blastemal (undifferentiated, embryonic) cells • Epithelial cells • Mesenchymal cells • Benign or malignant Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only en.wikibooks.org/.../Pregnancy_and_birth

  6. Necropsy Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  7. Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  8. Histopathology Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  9. Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  10. Immunohistochemistry Vimentin Desmin Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  11. Immunohistochemstry Smooth muscle actin Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  12. Immunohistochemistry Cytokeratin Cytokeratin Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  13. Periodic acid-Schiff Basement membrane Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  14. Morphologic Diagnosis • Malignant nephroblastoma, triphasic, kidney, with metastasis to liver, spleen, and mesentery. Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  15. Wilms’ tumor in children • Inactivation of the Wilms’ tumor gene (WT1) • WT1 protein is a transcription factor that functions as a tumor suppressor gene • Is expressed during renal and gonadal development • Defects in WT1 gene prevents normal differentiation of metanephric stem cells • Other genetic defects identified in children with Wilms’ tumor ( including WT2, WT3, WT4) Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  16. Questions? • Thanks to Dr. Eva Sartin, Beth Landreth, UschiWolfert for technical assistance in histopathology. Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  17. Histopathology Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  18. Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

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