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Serbia - Italia Bilateral Cooperation

Serbia - Italia Bilateral Cooperation ACETYLCHOLINESTERASE INHIBITORY ACTIVITY OF THIO-AVAROL DERIVATIVES 25th and 26th June, 2012. Beograd. Pozzuoli - Napoli. The Sponges. Dysidea avara. Dr. Salvatore De Rosa Dirigente di Ricerca National Research Council of Italy

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Serbia - Italia Bilateral Cooperation

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  1. Serbia - Italia Bilateral Cooperation ACETYLCHOLINESTERASE INHIBITORY ACTIVITY OF THIO-AVAROL DERIVATIVES 25th and 26th June, 2012

  2. Beograd

  3. Pozzuoli - Napoli

  4. The Sponges Dysidea avara

  5. Dr. Salvatore De Rosa Dirigente di Ricerca National Research Council of Italy Institute of Biomolecular Chemistry CNR-ICB E-mail: sderosa@icb.cnr.it

  6. Dr. Giuseppina Tommonaro Ricercatore National Research Council of Italy Institute of Biomolecular Chemistry CNR-ICB E-mail: gtommonaro@icb.cnr.it

  7. Mr. Carmine Iodice CollaboratoreTecnico ente di Ricerca National Research Council of Italy Institute of Biomolecular Chemistry CNR-ICB E-mail: ciodice@icb.cnr.it

  8. Avarolis a marine sesquiterpene hydroquinone possesing a rearanged drimane skeleton. Avarone is the quinone form of avarol.

  9. Avarol Avarone

  10. Avarolwas found to have anti-inflammatory antipsoriatic antioxidant antitumor antiplatelet analgesic anti-HIV activities.

  11. Of particular interest is acetylcholinesterase inhibitory activity of thio-avarol derivativeswith a carboxylic group in the molecule, such as avarol-3‘-thiobenzoate avarol-3‘–thiolactate avarol-4‘–thiolactate

  12. TLC bioautographic assay (white spot on a purple background) 1 μg Galanthamine was used a positive control.

  13. Galanthamine0.01 μg

  14. Dr. Pietro AmodeoI RicercatoreNational Research Council of ItalyInstitute of Biomolecular ChemistryCNR-ICBE-mail: pamodeo@icb.cnr.it

  15. Dr. Rosa Maria VitaleRicercatoreNational Research Council of ItalyInstitute of Biomolecular ChemistryCNR-ICBE-mail: rmvitale@icb.cnr.it

  16. Binding propertiesof avarol and its inhibitory derivativesto the enzymehave been characterising by computationalapproach.This research aims to design new avarol derivatives which better inhibitacetylcholinesterase.

  17. Serbia - ItaliaINSIEME NELLA SCIENZA,INSIEME NELLA VITA

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