1 / 4

Disclosure/Disclaimer

Disclosure/Disclaimer. The Molecular Biomarkers in Cancer ( MBiC ) slide presentation is not an independent educational program, and no CME credits will be provided.

ardelle-york
Télécharger la présentation

Disclosure/Disclaimer

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Disclosure/Disclaimer • The Molecular Biomarkers in Cancer (MBiC) slide presentation is not an independent educational program, and no CME credits will be provided. • This program is not intended to promote any cancer agent or class approved by the FDA/EMA or currently under clinical development. • The contents of this slide presentation are owned solely by Genentech; any unauthorized uses are prohibited. • This program is presented on behalf of Genentech and the information presented is consistent with FDA guidelines. • The following slides are selected samples from a complete presentation. They are for educational purposes only. BIO0002078200 1

  2. Types of cancer biomarkers and their utility Notes Screeningdiagnostic Prognostic Monitor progression Predictive Screening Resistance Biomarkers can play a significant role during the clinical management of cancer. Reference: Ludwig JA, Weinstein JN. Biomarkers in cancer staging, prognosis and treatment selection. Nat Rev Cancer. 2005;5:845-856. Initiatingevents Earliestmoleculardetection Earliestclinical detection Typical intervention Second-line treatment Disease burden Cost / irreversibility Ludwig JA, Weinstein JN. Nat Rev Cancer. 2005;5:845-856. Vogelstein B, et al. Nat Med. 2004;10:789-799. 2

  3. Methods of biomarker detection Notes cDNA microarrays provide a powerful tool for studying differential changes in gene expression patterns across a variety of tumor samples. Reference: Yang YH, Speed T. Design issues for cDNA microarray experiments. Nat Rev Genet. 2002;3:579-588. Cancer cells Normal cells IsolatemRNAs Tumor gene expression Make red and greenfluorescent cDNAs Hybridization Analyze data Microarrays Yang YH, Speed T. Nat Rev Genet. 2002;3:579-588. 3

  4. Measuring the risk of metastatic potential Notes • A simultaneous measurement of 70 cancer-related genes in tumor specimens by microarray technology • Evaluates genes involved in cell-cycle regulation, angiogenesis, invasion, signal transduction, and migration • Test measures the 10-year risk of metastasis for women with lymph-node–negative, ER–positive, or ER–negative disease An expression signature determined through the 70-gene microarray test can be used to stratify patients into high- and low-risk groups. Reference: Ma L, Weinberg RA. Micromanagers of malignancy: role of microRNAs in regulating metastasis. Trends Genet. 2008;24:448-456. Potential markers for metastasis Low risk Cancer Patient A No metastatic potential; conservative therapy possible Cancer biopsy High risk Cancer Patient B Metastatic potential; aggressive therapy needed Cancer biopsy ER=estrogenreceptor. van'tVeerLJ, Bernards R. Nature. 2008;452:564-570. Ma L, Weinberg RA. Trends Genet. 2008;24:448-456.Adaptedfrom Weinberg. Sci Am. 1996;275:62-70. 4

More Related