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ALZHIEMERS DISEASE IN UK ‘’The Dementia Time bomb’’

ALZHIEMERS DISEASE IN UK ‘’The Dementia Time bomb’’. By VISHAL ZAVERI AND ORE AJAI. What is Alzheimer's disease ?. Dementia= death of neuronal cells in the brain causing memory loss. Some forms are reversible and some are irreversible

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ALZHIEMERS DISEASE IN UK ‘’The Dementia Time bomb’’

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  1. ALZHIEMERS DISEASE IN UK ‘’The Dementia Time bomb’’ By VISHAL ZAVERI AND ORE AJAI

  2. What is Alzheimer's disease? • Dementia= death of neuronal cells in the brain causing memory loss. Some forms are reversible and some are irreversible • Alzheimer's disease: progressive neuronal cell death deteriorating all regions of the brain stopping physical and mental functioning. (3-20 yrs+) Causing loss of • Memory • Cognitive functioning • Speech • Vision • Ultimately leading to death!

  3. Epidimeology 820,000 cases of dementia in UK 450,000 cases are Alzhiemer’s Financial cost is over £23bn pa, that is twice that of cancer, three times the impact of heart disease and four times that of stroke Men, Women and all racial, economic and social groups are affected. AD is not natural for ageing it is pathological! Youngest age- 28 years

  4. Proposed Pathogenesis Described by AloisAlzhiemer’s- 105 years ago Still nothing has been done !

  5. Stages and Symptoms Early Alzheimer's Moderate Thinking & Planning SENSES Speaking and understanding Learning and STM memory severe Whole cortex is damaged LTM affected

  6. Risk factors • Genetic Factors- rare Familial AD- causing early onset AD – mutations in APP gene(chr21), OR presenilin genes(PSEN-1 (chr14) OR PSEN-2(chr1). Late onset- APOE-4 (everyone has one copy). Down Syndrome- both mutations for APP and DS- tend to always get AD at 40yrs. Environmental Other Head injuries with loss of consciousness= *3 Depression Ingestion of Aluminium salts MCI Countryside Obesity Mother’s age at your birth Diabetes

  7. Diagnosis PET scan-glucose metabolism

  8. Treatment • Incurable but symptoms can be managed Cholinesterase inhibitors Aricept, Exelon(patch), Razadyne Glutamate regulator Namenda for severe AD

  9. Current research Current Research • Researchers in 2013 studied mice and found that after administering mice with Alzhiemer’s disease, neuronal cell death stopped! • However side effects were ample! • Latest drug failure- Gammagard

  10. References • http://medicineworld.org/cancer/lead/7-2007/symptoms-of-severe-alzheimers-disease.html • http://www.ctvnews.ca/health/alzheimer-s-researchers-say-they-are-undeterred-by-latest-drug-failure-1.1297965 • http://www.alz.org/alzheimers_disease_1973.asp • http://www.triumf.ca/research-highlights/experimental-result/cutting-edge-alzheimers-research • http://www.alzheimersresearchuk.org/ • http://www.brightfocus.org/alzheimers/about/understanding/plaques-and-tangles.html

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