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Brain graphs of Women and Men

Brain graphs of Women and Men. Balázs Szalkai, ELTE Institute of Mathematics. The brain from a mathematical point of view. Connectome: nodes=neurons, edges=axons. The brain from a mathematical point of view. Macro-scale connectome : nodes = ROIs ( regions of interest), edges = axons.

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Brain graphs of Women and Men

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  1. Braingraphs of Women and Men Balázs Szalkai, ELTE Institute of Mathematics

  2. The brain from a mathematical point of view Connectome: nodes=neurons, edges=axons

  3. The brain from a mathematical point of view Macro-scaleconnectome: nodes=ROIs (regions of interest), edges=axons

  4. Computing a macro-scaleconnectome • Diffusion MRI scan • Segmentation • Parcellation • Tractography • Graphconstruction

  5. Computing a macro-scaleconnectome • Diffusion MRI scan • Segmentation • Parcellation • Tractography • Graphconstruction

  6. Computing a macro-scaleconnectome • Diffusion MRI scan • Segmentation • Parcellation • Tractography • Graphconstruction

  7. Computing a macro-scaleconnectome • Diffusion MRI scan • Segmentation • Parcellation • Tractography • Graphconstruction

  8. Computing a macro-scaleconnectome • Diffusion MRI scan • Segmentation • Parcellation • Tractography • Graphconstruction

  9. Materials and Methods • Human Connectome Project • Healthymale and femalesubjects, age 22—35 • 96 subjects (52 females and 44 males) • 83, 129, 234, 463 and 1015-node resolutions • 5 differentweightfunctions • Mathematicalanalysis

  10. Whatweknowaboutbrain and gender • Femaleshave… • smallerbrains • largergray/whiteratio • largercorticalthicknessand corticalcomplexity • Hippocampus and amygdala • Homosexualityand braincharacteristics of theoppositesex (Savic, Lindström 2008)

  11. Our results • Women’sbrains… • …havemore edgesongeneral • Densernetwork

  12. Our results • …have a largerminimum bisectionwidth • The minimum bisection ≈ separatesthe 2 hemispheres

  13. Our results • …arebetterexpander graphs • Nodegroupshave more neighbors

  14. Our results • …have more spanningtrees

  15. Conclusion • Firstapplication of graphtheoryonbraingraphs • (asopposedtonetworkscience) • Women’sbraingraphs: denser and more effectivenetworks • Notexplainedsolelybythephysicalsize of thebrain

  16. Thank you for your attention! Szalkai B, Varga B, Grolmusz V (2015) Graph Theoretical Analysis Reveals: Women’s Brains Are Better Connected than Men’s. PLoS ONE 10(7): e0130045.doi: 10.1371/journal.pone.0130045

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