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Somatosensory System and Pain

08-9 פיסיולוגיה מורחב. Somatosensory System and Pain. lecture 3: The primary somatosensory neuron. Prof. Marshall Devor, Ph.D. Dept. of Cell & Animal Biology and Center for Research on Pain Institute of Life Sciences Hebrew University of Jerusalem. primary sensory neuron.

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Somatosensory System and Pain

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  1. 08-9 פיסיולוגיה מורחב Somatosensory System and Pain lecture 3: The primary somatosensory neuron Prof. Marshall Devor, Ph.D. Dept. of Cell & Animal Biology and Center for Research on Pain Institute of Life Sciences Hebrew University of Jerusalem

  2. primary sensory neuron

  3. from stimulus to impulse train…variety • 1. force transmission • to sensory ending • transduction • spike encoding

  4. primary sensory neuron

  5. neural crest neural crest

  6. bipolar pseudounipolar Primary sensory neurons are pseudounipolar growth cone sensory ending

  7. A A C

  8. CGRPpeptide neurotransmitter RT97neurofilament 100 uM

  9. Theory of "target derived neurotrophism"

  10. Matsuda et al

  11. no synaptic contacts in DRG

  12. microvilli on DRG somata • enlarged surface area • numerous neurotransmitter • and other receptor types

  13. primary sensory neurons

  14. nociceptors

  15. epineurial blood vessel axon perineurium endoneurium skin nerve muscle nerve m/sec A, A Ia, Ib, II 15-100+ A III 2-15 C (Remak bundle) IV 0.2-2

  16. Schwann cell soma nodal gap 2 um node of Ranvier paranode 1-2 mm internode

  17. myelin formation Schwann cell (glia) internode 1-2 mm node of Ranvier 1-2 um 30 um

  18. myelin formation axon, myelin, Schwann cell, oligodendroglia

  19. axon, myelin, Schwann cell

  20. myelin formation in the CNS Schwann cell vs. oligodendroglial cell

  21. node of Ranvier

  22. contactin associated protein

  23. adult: DRG neuron phenotype depends on regulation of both expression and traffic of molecules of excitability (NTs)

  24. variety of primary afferent neurons (stimulus encoding) A: LTMs: SA, RA, PC, hair A: warming, cooling, down hair, mechano-nociceptors C: mechanical nociceptors mechano-heat nociceptors CMH polymodal nociceptors silent nociceptors

  25. “neuronal phenotype”(correlates of sensory receptor types) DRG peptides: SP, CGRP, NPY, NT, VIP, SOM, GAL, CCK… substance P, calcitonin gene related peptide….

  26. “neuronal phenotype” (correlates of sensory receptor types) DRG peptides: SP, CGRP, NPY, NT, VIP, SOM, GAL, CCK…

  27. פיסיולוגיה מורחב Somatosensory System and Pain lecture 3: The primary sensory neuron Prof. Marshall Devor, Ph.D. Dept. of Cell & Animal Biology and Center for Research on Pain Institute of Life Sciences Hebrew University of Jerusalem

  28. spike invasion and the safety of through-conduction in DRG neurons …. why are DRG neurons excitable ?

  29. somatic through-conduction spike invasion NEURON simulation Conclusion: spike invasion is a design feature of DRG neurons… but to what end ??

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