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Myopic LASIK Visual Outcomes of Wavefront -Guided Ablation with Iris Registration

Myopic LASIK Visual Outcomes of Wavefront -Guided Ablation with Iris Registration. Mouhab Aljajeh, M.D., Engy Mohamed, M.D., Wayne Bowman, M.D., Dwight Cavanagh, M.D., PhD., Steven Verity, M.D., James McCulley M.D.,FRCOphth (UK). Financial Disclosure : .

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Myopic LASIK Visual Outcomes of Wavefront -Guided Ablation with Iris Registration

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  1. Myopic LASIK Visual Outcomes of Wavefront-Guided Ablation with Iris Registration Mouhab Aljajeh, M.D., Engy Mohamed, M.D., Wayne Bowman, M.D., Dwight Cavanagh, M.D., PhD., Steven Verity, M.D., James McCulley M.D.,FRCOphth (UK) Financial Disclosure: Dr. McCulleyis a consultant of Alcon Inc. No financial interest of any of the other authors Supported in part by an unrestricted research grant from Research to Prevent Blindness, Inc., New York, New York.

  2. Background • Wavefront-guided refractive surgery is designed to correct High-order Aberration (HOA) as well as sphere and cylinder. • The position of the pupil center shifts as the pupils size changes.1-3 A static decentration of wavefront-guided ablation may occur due to pupil centroid shift as laser refractive surgeries are usually performed under photopic conditions whereas, wavefront measurements are often performed under mesopic condition 1 Yang y, Thompson K, Burns SA: Pupil location under mesopic, photopic, pharmacologically dilated conditions. Invest Ophthalmol Vis Sci 2002;43:2508-2512 2 Walsh G: The effect of mydraiasis on pupilarycentration of human eye. Ophthalmic physiol 1988;178-182 3 Wilson MA, Campbell MCW,Simonet P: Change of pupil centration with change of illumination and pupils size; the Julius F. Neumueller Award in optics, 1989 Optom Vis SCI 1992;69:129-136

  3. Purpose • In this study, our purpose was to evaluate visual and clinical outcomes of wavefront-guided laser in situ keratomileusis (LASIK) with iris registration platform (VISX CustomVue, VISX Inc., Santa Clara, CA) in myopic correction.

  4. Methods • Prospective analysis was used to evaluate wavefront-guided myopic LASIK with iris registration in a consecutive cohort of 123 eyes (66 patients; 38 males) with no history of ocular inflammation, trauma, or systemic disease affecting vision

  5. Methods • The primary outcome variables assessed pre-operatively and postoperatively at 1 and 3 months were: • Uncorrected visual acuity (UCVA) • Best spectacle-corrected visual acuity (BSCVA) • Manifest refraction, • High order aberrations, using VISX aberrometer. • Contrast sensitivity using the CSV-1000HGT charts

  6. Results • Mean age was 39.2±10 years (21 to 61 years). • Mean pre-treatment spherical equivalent (SE) was reduced from -3.4±2.0 D to -0.2±0.3D (range -1.25 to 0.5) (p <0.001) at 3 months. • At 3 months, UCVA was 20/25 or better in 89% (95% of eyes after retreatment of nine eyes). • 10% of eyes gained one line of BSCVA and 86% were within ±0.50D at 3 months.

  7. Predictability Spherical equivalent at 3 months postoperative Attempted vs achieved spherical equivalent

  8. Safety Loss or Gain in BSCVA

  9. Efficacy UCVA at 1 week, 1 month and 3 month follow-up

  10. Total HOA increased significantly from (0.38±0.15µm) to (0.45±0.22µm) (p<0.001). • Spherical aberrations increased (p=0.001) while Coma increased (p=0.4). • Trefoil decreased (p<0.002) at 3 months.

  11. Contrast sensitivity improved under glare conditions (p <0.001) at 3 months.

  12. Conclusion • Wavefront-guided LASIK with iris registration using VISX S4 IR platform is an effective, predictable, and safe procedure for treating refractive errors.

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