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Autoimmune polyendocrinopathy

Autoimmune polyendocrinopathy. Polyglandular autoimmune syndrome. Endocrine glands. Pancreas Ovaries Testes Thyroid Parathyroids Adrenals. PAS. group of disorders characterized by: endocrine tissue destruction leading to multiple glands malfunction.

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Autoimmune polyendocrinopathy

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  1. Autoimmune polyendocrinopathy Polyglandular autoimmune syndrome

  2. Endocrine glands • Pancreas • Ovaries • Testes • Thyroid • Parathyroids • Adrenals

  3. PAS • group of disorders characterized by: • endocrine tissue destruction leading to multiple glands malfunction. • Genetics play a role in determining who develops PAS.

  4. 4 types • Type 1 PAS: • Common in age of 10 to 12 yrs. • Rare genetic • starts with chronic candidiasis progresses to parathyroids and adrenals resulting into hypoparathyroidism and Addison's disease. Other related autoimmune disorders can develop over the years.

  5. Type 2 • In adults • women three times • Starts with adrenals (Addison’s disease) and progresses to: -Thyroid (hypothyroidism) -Pancreas (Type 1 diabetes mellitus)

  6. Type 3 • Mainly affects women in their 30's. • Starts with thyroid dysfunction and progresses to other autoimmune disorders including diabetes, pernicious anemia, coeliac disease and many of the same conditions that occur in PAS 1 and 2. • It doesn't typically include adrenal gland malfunction.

  7. Type 4 • have two or more autoimmune endocrine diseases that don't follow the typical pattern for the other types of PAS. • For instance, a person may have type 1 diabetes first and then goes on to develop coeliac disease without adrenal or thyroid involvement.

  8. Treatment • Replacement of the deficient hormone(s)

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