1 / 22

THINGS YOU NEED TO KNOW ABOUT PREPARING AN NIH GRANT – THE PI’S PERSPECTIVE

THINGS YOU NEED TO KNOW ABOUT PREPARING AN NIH GRANT – THE PI’S PERSPECTIVE. Leslie J. Raffel M.D. 1) Start early 2) Start early 3) Start early 4) When you don’t start early enough (and even if you do), get good at staying up late and writing in the wee hours of the morning.

bobby
Télécharger la présentation

THINGS YOU NEED TO KNOW ABOUT PREPARING AN NIH GRANT – THE PI’S PERSPECTIVE

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. THINGS YOU NEED TO KNOW ABOUT PREPARING AN NIH GRANT – THE PI’S PERSPECTIVE Leslie J. Raffel M.D.

  2. 1) Start early2) Start early3) Start early4) When you don’t start early enough (and even if you do), get good at staying up late and writing in the wee hours of the morning

  3. 5) Think clearly about what type of proposal you are submitting and make sure you write the grant to address those concernsa) If you are writing a K23 or other training grant, be sure to address the issue of how this will increase your likelihood of becoming an independent investigator and be sure to include a description of the training component

  4. b) If you are responding to a specific RFA, make sure that your proposal is really within the range of what that RFA covers (example – don’t submit an application on Type 2 diabetes when the RFA is for Type 1 diabetes)c) Particularly for RFA’s, it is often worthwhile to talk to the program officer in advance – sometimes you can get a better sense of whether your proposal is likely to be appropriate from a phone call than from just reading the RFA

  5. d) If it sounds too good – bewareSometimes RFA’s are set-ups, where the NIH is designing it for a specific group, and you don’t want to waste your time if you don’t have a chance of getting funded

  6. WRITING THE PROPOSAL 1) Tell a story2) Use lots of figures, tables and illustrations a) visuals help to get the point across and also break up never-ending page after page of text

  7. 3) Specific Aims are very importanta) Make them succinct, carefully writtenb) Hypothesis driven – sometimes you will have an aim that is to create a resource, etc. but try and keep these to a minimum

  8. c) Don’t propose more than is reasonable – being ambitious is good, but only within reason – remember you only have at most 5 years to accomplish these aims d) Make your aims consistent with your budget – don’t propose studying 5000 people with a budget of $50,000/year when in reality that would cost $500,000/year

  9. e) Have a brief introduction to get the reviewer interested (i.e. your topic is important) and a brief conclusion/summary (your topic is important and will lead to bigger and better things)

  10. 4) Background sectiona) Don’t run too long, but give a comprehensive overview of what is known about the topic of your proposali) Don’t assume that the reviewer is an expert in the field – give enough background information so that someone who isn’t very familiar with the area will feel as though they understand what has and hasn’t been done, what is and isn’t known

  11. ii) Don’t assume that the review isn’t an expert in the field – be careful not to denigrate the work of another researcher, lest it turn out that he/she is your primary reviewer…..iii) In addition to general background re your area of research, you may want to give background concerning specific methodologies that are key to your study design

  12. 5) Preliminary Data/Relevant Worka) This section is very important! i) If you don’t have preliminary data, why are you writing the grant???

  13. ii) Especially for young investigators (but really for everyone), if you don’t have lots of preliminary data directly related to your study proposal, you may want to include experience you have had that is relevant to the likelihood that you will be able to accomplish the aims of the proposal – i.e. involvement in similar types of studies (epidemiological, family design, molecular biology, pathophysiology, etc.) to the current proposal, facility with particular techniques that will be used in the study, etc.

  14. iii) Whenever possible, have publications to reference for your preliminary data – Abstracts help, but peer-review publications are better – It is ok to have some preliminary data that is ‘hot off the presses’ and unpublished, but your credibility will be much higher if you have relevant peer- review publications

  15. 6) Methodsa) Because space is usually getting short by now, you may need to abbreviate descriptions of some of you methodologyb) If you need to shorten descriptions, be sure to reference well (don’t assume that the specific procedure you will use is obvious) and consider including more detail in an appendix (but only if this is really going to benefit the reviewers – don’t pad – think how you would feel if you were the one reading this proposal…)

  16. c) There are 2 approaches to organizing the methods sectioni) Go through the methods in a chronological fashionii) Divide your methods by specific aimiii) The second seems to be in vogue at presentiv) However you organize, make sure that reviewers will be able to follow what methods you will be using to achieve each aim

  17. d) If there is controversy as to which method to use, address this and justify your selectione) Flow charts to present overall study design and how the different aims interact are often helpful

  18. 7) Problems/Pitfallsa) Things always go wrong in scienceb) Show that you have given some thought to what problems are most likely to occur and how you would proceed if a problem does arise

  19. 8) Referencesa) Be carefulb) Be consistentc) Make sure you actually reference these in your textd) Author et al citations in text are easier to follow but take more roome) OK to use numerical referencing, but check your numbers – reviewers aren’t happy when they check a reference and find it is unrelated to the text

  20. 9) Human Subjects a) This used to be the last thing anyone wrote, typically just cutting and pasting from somewhere elseb) NIH reviewers are now being told to use human subjects protection concerns in scoringc) What you put in your grant doesn’t need to be as detailed as your IRB submission materials, but pay attention, show that you are aware of human protection issues (including privacy/confidentiality)

  21. Last but not least…If you have paid heed to advice #1-3 (you started early), ask a colleague to read your grant and critique it – feedback is incredibly important, particularly if you are new to the process If you don’t have time to send it to someone else, put the grant down for 12 hours, walk away and then read once more, as though for the first time. Pay attention to what you have written, not what you think you have written

  22. Grants do not get finished, you simply run out of time…...

More Related