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Male Genital System 1

Male Genital System 1. Dr. Amitabha Basu MD. Penis. Mal formations Inflammatory conditions Premalignant lesions and malignant conditions. Mal formations of penis. Epispadias: Infection and urinary incontinence. Inflammation of penis and prepuce.

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Male Genital System 1

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  1. Male Genital System1 Dr. Amitabha Basu MD

  2. Penis • Mal formations • Inflammatory conditions • Premalignant lesions and malignant conditions

  3. Mal formations of penis

  4. Epispadias: Infection and urinary incontinence.

  5. Inflammation of penis and prepuce Banalities & Balanoprosthitis : Hyperemia and exudates.

  6. Banalities & Balanoprosthitis Complications : Phimosis and Paraphimosis Paraphimosis

  7. Genital candidiacis • Etiology: Diabetes Mellitus

  8. Penis • Premalignant lesions • Malignant conditions

  9. Premalignant lesions • Etiology • Carcinogens in smegma • HPV type 16

  10. Types of Premalignant lesions : Penis • Carcinoma in situ ( Following types). • Bowen disease (HPV type 16). • Erythroplasia of Queyrat (HPV type 16) • Bowenoid Papulosis (Etiology = Venerally transmitted diseases)

  11. Bowen disease : gross – Solitary plaque like lesion

  12. Bowen disease : micro – in situ carcinoma ; intact basement membrane ; severely dysplastic epithelium 10 % progress to invasive carcinoma

  13. Etiology Types of malignancy Morphology Clinical features Squamous cell carcinoma Verrucous carcinoma Malignant lesion pf Penis

  14. Etiology of carcinoma penis • Carcinogens in smegma • HPV type 16

  15. Squamous cells carcinoma : penis This is a squamous cell carcinoma of the penis ( penectomy specimen )

  16. Keratinized squamous cell carcinoma

  17. Verrucous carcinoma : Papillary growth pattern- good prognosis.

  18. Scrotun , Testis and epididymis • Cryptorchidism • Inflammatory conditions of testis • Male infertility • Hydrocele • Hematocele, chylocele, elephantiasis • Testicular torsion

  19. Cryptorchidism : Definition • Definition: crypto=hidden, orchid= testicle, • Testis fails to descend in the scrotum by age 12 months. • Cause: • Hormonal abnormality • Intrinsic testicular abnormality. • Mechanical obstruction in inguinal canal.

  20. Morphology ( Testicular atrophy) • Right testis more commonly involves. Small testis. • Tubular atrophy with hyalinization present.

  21. Microscopy of Atrophic Tubules ( diffuse) of testis.

  22. Complication ; Cryptorchidism • Infertility • Seminoma ( malignancy) particularly with unilateral undescended testis.

  23. Causes of testiculate atrophy and that may lead to Infertility • Cryptoorchitism ( unilateral / bilateral). • Chronic alcoholism ( Bilateral) • Chronic Ischemia ( unilateral / bilateral) • Chemotherapy or radiation ( Bilateral) • Mumps orchitis ( focal atrophy) Never forget

  24. Inflammatory lesion of testis • Epididymitis • Orchitis.

  25. Testis : infection

  26. Orchitis. Etiology • Mumps ( mumps orchitis ) : common in adult. • Plasma cells and lymphocytes are present.

  27. Focal atrophy of the testis tubules ; Mumps orchitis NORMAL

  28. Laboratory • Sperm count will be low BUT not NIL. • Infertility do not occur usually.

  29. Tuberculosis • Epithelioid cell granuloma is present with cassation necrosis.

  30. Causes of Male Infertility 1 of 2 • Mumps (unilateral / Bilateral)- temporary infertility. • Cryptoorchitism ( unilateral / bilateral). • Chronic alcoholism ( Bilateral) • Chronic Ischemia ( unilateral / bilateral) • Chemotherapy or radiation ( Bilateral) • Hydrocele and Varicocele Never forget

  31. Other causes of male infertility 2 of 2 • Klienfelter syndrome : patient present with gyenecomastia. • Sertoli cell-only syndrome : No Sperm-Producing Cells, tubules contain only Sertoli cells.

  32. Sertoli cell-only syndrome; sperm count NIL.

  33. Hydrocele : etiology • Inflammation • Idiopathic

  34. Hydrocele : Accumulation of serous fluid in tunica vaginalis.

  35. Hematocele, chylocele, elephantiasis • Hematocele : blood in tunica vaginalis ( in trauma) • Chylocele : lymph in tunica vaginalis ( in lymphatic obstruction). • Elephantiasis : in filarial infection ( lymphatic obstruction).

  36. Elephantiasis

  37. Varicocele : Dilation of the pampiniform plexus Complication : infertility

  38. Testicular torsion : hemorrhagic infarction Etiology : Trauma or tumor in the testis

  39. Testis

  40. Self assessment • Premalignant lesion of Penis • Causes of infertility • Etiology of testicular atrophy.

  41. Self assessment • Cryptorchidism and clinical significance • Carcinoma penis: Type: prognosis, microscopy

  42. Thank you

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