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A Powerful Natural Anti-Inflammatory

A Powerful Natural Anti-Inflammatory. The Role of the Ratio of Omega 6s to Omega 3s in Optimal Health. The superior Marine Lipid Complex. Essential Fatty Acids. R equired by the human body to manufacture and repair cell membranes Protect cells from inflammation

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A Powerful Natural Anti-Inflammatory

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  1. A Powerful Natural Anti-Inflammatory The Role of the Ratio of Omega 6s to Omega 3s in Optimal Health The superior Marine Lipid Complex

  2. Essential Fatty Acids • Required by the human body to manufacture and repair cell membranes • Protect cells from inflammation • Cannot be made in sufficient quantities therefore must be obtained from food • Two types: • Alpha-linolenic acid (Omega-3) • Linoleic acid (Omega-6)

  3. Omega 6 and 3 Fish /Marine Oils Walnuts

  4. Omega 3/Omega 6 Imbalance • Changes in food manufacturing processes have resulted in high amounts of Omega 6 • Hydrogenated oils • High-fructose corn syrup • Genetically engineered corn and soy products

  5. Omega 3/Omega 6 Ratio

  6. Inflammatory Pathways Omega3 Foods Walnuts Flaxseed Green Vegetables Omega6 Foods Corn Oil Soy Oil Safflower Oil Pro-Inflammatory Linoleic Acid (LA) Arachidonic Acid (AA) Alpha- Linolenic- Acid (ALA) EPA/DHA Fish/ Animal Sources COX1 COX2 5LOX PGG2 5-HPETE Anti-Inflammatory Leucotriene A4 PGH2 Leucotriene B4 Thromboxane (TXA) CysteinylLeucotrienes Prostaglandins (PG2) Leucotriene (B5) Prostaglandins (PG3) Thromboxane (LTB5)

  7. Omega 3/6 Imbalance Leads to Inflammation • Bodies natural biological protective response of tissue to harmful stimuli • Pathogens • Cell damage • Irritants • Chronic inflammation characterized by simultaneous tissue healing and destruction

  8. Inflammation is the Basis of Most Degenerative Disease • Asthma • Alzheimer’s • Cardiovascular Disease • Metabolic Syndrome • Osteoarthritis • Rheumatoid Arthritis • Inflammatory Bowel Disease • Dysmenorrhea • Delayed Muscle Soreness • And many more….

  9. Effects of Reducing Omega-6:Omega-3 Ratio • In secondary prevention of cardiovascular disease, a ratio of 4:1 Omega-6 to Omega-3 fatty acids associated with 70% decrease in total mortality DeLongeril M, er al. Mediterranean alpha-linoleic acid-rich diet in secondary prevention of coronary heart disease. Lancet 1994; 343: 1454-9.

  10. Effects of Reducing Omega-6:Omega-3 Ratio • Lowering the ratio to 5:1, resulted in alterations in 5-series leukotriene excretion in an asthmatics in ameliorating methacholine-induced respiratory distress Broughton KS, et al. Reduced asthma symptoms with omega-3 fatty acid ingestion are related to 5-series leukotriene production. Am J ClinNutr 1997; 65: 1011-17.

  11. Effects of Reducing Omega-6:Omega-3 Ratio • Lowering the Omega-6: Omega-3 ratio by 4:1 by using 4gm of omega-3 fatty acids produced inhibition of production of IL-1β and TNFα associated with rheumatoid arthritis James MJ, Cleland LG. Dietary omega-3 fatty acids and therapy for rheumatoid arthritis. Semin Arthritis Rheum 1997; 27: 85-97.

  12. The OMAPREM Difference • With 30 years of Clinical Studies, OMAPREM is proven to be a Powerful, Effective Cox-2 and 5Lox inhibitor. • In addition to EPA and DHA, OMAPREM contains over 30 fatty acids that contribute to its anti inflammatory benefits. As well as 4 novel compounds* *Anti-cyclooxygenase effects of lipid extracts from the New Zealand green-lipped mussel (Perna canaliculus)(PCSO-524™) S. McPhee a , L .D. Hodges a , P.F.A. Wright b , P.M. Wynne c , N. Kalafatis a , D.W. Harney a, T.A. Macrides a,⁎ *Novel anti-inflammatory ω-3 PUFAs from the New Zealand green-lipped mussel, Perna canaliculus A.P. Treschow a, L.D. Hodges a, P.F.A. Wright b, P.M. Wynne c, N. Kalafatis a, T.A. Macrides a,⁎ OMAPREM COX2 Inflammation 5LOX Inflammation / Swelling

  13. OMAPREM Novel Compounds • A structurally related family of ω-3 PUFAs was identified in the most bioactive fractions, which included: • C18:4 • C19:4 • C20:4 • C21:5 • The novel compounds may be biologically significant as AI agents, as a result of their in vitro inhibition of lipoxygenase products of the AA pathway. *Novel anti-inflammatory ω-3 PUFAs from the New Zealand green-lipped mussel, Perna canaliculus A.P. Treschow a, L.D. Hodges a, P.F.A. Wright b, P.M. Wynne c, N. Kalafatis a, T.A. Macrides a,⁎

  14. OMAPREM The Superior Choice • Purity • Potency • Efficacy • Science • Partner Program

  15. Purity

  16. Fish Oil Source • May contain man made pollutants if taken from natural sources • Heavy Metals • PCB’s • Pesticides • Radiation • Farm raised fish have lower amounts of Omega 3s and higher amounts of Omega 6s due to corn/grain diet • Bio-magnification http://www.hsph.harvard.edu/nutritionsource/fish/

  17. Fish Oil Source • Fish, like salmon, consume smaller fish or krill that consume the plankton. • Fish also can absorb industrial contaminates (like mercury) by eating smaller fish. • The farther up the food chain the higher the level of contaminates http://www.hsph.harvard.edu/nutritionsource/fish/

  18. Krill- Sustainability • National Geographic Magazine has warned about the 80 percent drop in krill populations over the last few decades • This drop could potentially harming already depleted whale and other marine mammal populations • Without krill, most of the life forms in the Antarctic would disappear. http://animals.nationalgeographic.com/animals/invertebrates/krill.html

  19. OMAPREM Purity • Green lipped mussels • Sustainably farmed in the pristine waters of New Zealand’s Marlborough Sound. • Evolved to have extraordinary antioxidant content due to ozone deficiency • Blue Ocean Institute, ranked New Zealand Green-lipped mussels as one of the top two ‘eco-friendly seafoods’ in the world.* *http://www.purenzgreenshell.com/aquaculture/quality-assurance/sustainability.cfm

  20. Marine Oil Extraction Process • Cold press • Distillation • Supercritical fluid extraction

  21. Marine Oil Extraction Process • Cold press and distillation processes result in bound forms of essential fatty acids • Triglyceride • Ethyl esters • More metabolic processing required by the body in order for absorption

  22. Marine Oil Extraction Process Extraction Processes Bioavailability • Free Fatty Acids - easily absorbed and have been shown to have superior bioavailability* • Triglyceride form- have a triglyceride “backbone” to the grouping of Fatty Acids • Ethyl Easter- The Fatty acids are grouped together. The body must add the triglyceride backbone for absorption • HUMAN ABSORBTION OF FISHOIL FATIY ACIDSAS TRIACYLGLYCERLS, FREE ACIDS, OR ETHYLESTERS • Tarry D. Lawson andBronwynG. Hughes

  23. Fatty Acid Absorption Triglyceride Form Free Fatty Acid Form PCSO-524 Ethyl Easter Form

  24. OMAPREM Extraction Process • SFE (CO2) Patented Supercritical Fluid Extraction • Dissolves nonpolar lipids from freeze dried mussel powder using combination of pressure and low temperature • Process process high quantity of Free Fatty Acids

  25. OMAPREM Extraction Process • Removes marine proteins  no allergy • Remove heavy metals  no toxins • Provides free fatty acid form for easy absorption into the bloodstream

  26. OMAPREM: Potency

  27. OMAPREM Potency Bioavailability The PCSO-524 oil used in OMAPREM has been shown to have 17to 22times more free fatty acid form DHA and EPA, in addition there are 4 novel fatty acids with greater bioactivity then standard fish oils. *Convance–Certificate of Analysis 594817-0 10-jul-2012, 594835-0,594836-0

  28. Multiple Fatty Acids Multiple Benefits Lauric acid • PCSO-524tm contains novel fatty acids in addition to 30+ fatty acids that can reduce inflammation many times better than other anti-inflammatory supplements. • The array of fatty acids offers many unique properties not found in any other marine source Caprylic acid ALA Stearic acid Docosapentaenoic acid (DPA)  Eicosatetraenoic acid (ETA) Linolenic acid Nervonicacid DHA Fish Oils contain little more than these Fatty Acids EPA

  29. Smaller & Superior One tiny capsule of OMAPREM is as powerful as 20 fish oil. Bioavailability of free fatty acid 5-10 times more in a much smaller quanitity Kataoka et al. Future Cardiol 2013; 9(2): 177-186.

  30. OMAPREM: Science

  31. Efficacy 30 Years Over 25 Studies Allergies Arthritis Asthma DOMS Dysmenorrhea Inflammatory Bowel Disease *Studies Available Upon Request

  32. Arthritis • 50 patients older than 50 years • Patients treated with PCSO-524™ showed a statistically significant improvement of both their pain symptoms related to osteoarthritis and improved quality of their daily lives (p = 0.05) • Conclusion: Reduction of pain was statistically evident at four weeks among the subjects who took capsules that contained PCSO-524™. • Practitioners can expect quicker long-term results with less risk of side effects for their osteoarthritis patients when they recommend products that contain PCSO-524™, compared with fish oil. Szechinski J et al. Measurement of pain relief resulting from the administration of Pernacanaliculus lipid complex PCSO-524™ as compared to fish oil for treating patients who suffer from osteoarthritis of hip and/or knee joints. Reumatologia 2011; 49: 244-252.

  33. Visual Analog Scale (Arthritis) 89%

  34. Quality of Life – Health Assessment Questionnaire Fish oil -91% Mean p < 0,05 Week

  35. Rheumatoid Arthritis • 12 week drug monitoring study evaluated the effects of PCSO-524™ on 50 adult men and women suffering from inflammatory rheumatoid arthritis • 21 of the 34 subjects (64%) reduced or terminated current drug therapy • 13 patients did not require further therapy • 38 % of all subjects were regarded as being free from disorders • Number of subjects suffering from severe pain was significantly decreased from 60% (at baseline) to 25 % (at 3 months) • A significant positive effect was observed for all investigated parameters Gruenwald J et al. Efficacy and tolerability of mussel-Lyprinol omega-3-complex on inflammatory rheumatoid disorders. PhytoPharm Research.

  36. Inflammatory Bowel Disease • The effect of pretreatment with PCSO-524™ on experimentally induced inflammatory bowel disease (IBD) in mice • Body weight and disease activity index (DAI) scores were recorded daily • Treatment significantly reduced body weight loss, DAI scores, crypt area losses, and cecum and colon weights, compared with control Tenikoff D et al. Stabilized lipid extract of New Zealand green-lipped mussel: a potential preventative treatment modality for inflammatory bowel disease. J Gastroenterol 2005; 40: 361-365.

  37. Asthma • Forty-six patients with atopic asthma received two capsules of lipid extract (PCSO-524™) or placebo b.i.d. for 8 weeks • Significant decrease in daytime wheeze concentration of exhaled H2O2 • Increase in morning PEF in the lipid extract group compared to the placebo group • No reported significant side effects Emelyanov A, et al. Treatment of asthma with lipid extract of New Zealand green-lipped mussel: a randomized clinical trial. EurRespir J 2002: 20: 596-600.

  38. Athletic Performance DOMS • PCSO-524®, derived from the New Zealand green-lipped mussel on DOMS after a 30 km training run. • One group was supplemented with 400 mg per day of PCSO-524® for 11 weeks, the other group with an olive oil placebo. • Conclusion: Pain sensations experienced by distance runners following a 30 km run were reduced by supplementation with the marine oil complex PCSO-524®, an effect which was greater in lesser trained runners

  39. No Known Side Effects Just Side Benefits • Pharmaceutical Options like • Codeine Based Pain Relievers • Cortisone • Immune Modulators • NSAIDs (COX1, COX2) • Create Side Effects Like • Cartilage deterioration, osteonecrosis, nerve damage, adrenal suppression, hyperglycemia • Immune suppression • Addiction • GI bleed, stroke, MI, renal failure

  40. The OMAPREM Advantage 100 • OMAPREM has been shown to be up to100times more effective than other fish oils 30+ • OMAPREM contains complex of 30+different fatty (Including EPA and DHA) acids. This array of fatty acids are unique to the green lipped mussel. • The fatty acids in OMAPREM are up to 22 times more free form than fish oil therefore easier for the body to absorb. 0 • 0 known side effects • 0 Drug to Drug interaction • 0 Contaminants • 0 to Lose!

  41. OMAPREM: Partner Program

  42. Benefit Your Patients and Your Practice $ 127,650 Chart based on 1 patient a day, a total of 25 patients each month. Ongoing Additional Quarterly Incentive 150-225 Bottles sold per quarter $1 extra per bottle 226-300 Bottles sold per quarter $2 extra per bottle 301-up Bottles sold per quarter $3 extra per bottle Profit Per Bottle $20 per 60 ct. bottle ($64.95 retail) $10 per 30 ct. bottle ($39.95 retail)

  43. For More Information www.OMAPREM.com!

  44. Order Online With Your Customized Link • Your own personal page is created to ease ordering for your patients

  45. OMAPREM’s Key Points for Patients • OMAPREM is a step in the right direction with improving your overall health and well being • OMAPREM’s top rated customer service staff is ready to assist you

  46. Take Advantage of the End of Year Special

  47. Call our customer service line (800-725-0376).  It is our intent to facilitate the most efficient and accurate way for your office to place and track orders. Order now!

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