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ADENOVIRUSES

Medical biology, microbiology, virology, immunology department. ADENOVIRUSES. By As.Pfof. E.V. Pokryshko. acute respiratory disease, pharyngoconjunctival fever, nonstreptococcal exudative pharyngitis, primary atypical pneumonia. Laboratory Diagnosis.

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ADENOVIRUSES

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  1. Medical biology, microbiology, virology, immunology department ADENOVIRUSES By As.Pfof. E.V. Pokryshko

  2. acute respiratory disease, • pharyngoconjunctival fever, • nonstreptococcal exudative pharyngitis, • primary atypical pneumonia

  3. Laboratory Diagnosis. The viruses have been recovered from throat swabs, conjunctival swabs, rectal swabs, stools of patients with acute pharyngitis and conjunctivitis, and urine of patients with acute hemorrhagic cystitis. Virus isolations from the eye are obtained mainly from patients with conjunctivitis.

  4. Laboratory Diagnosis. The viruses are isolated by inoculation of tissue cultures of human cells in which characteristic cytopathic changes are produced. A new serotype that has not been isolated in cell cultures can be detected by direct examination of fecal extracts by electron microscopy or by enzyme-linked immunosorbent assay.

  5. Laboratory Diagnosis. Serology. In most cases, the neutralizing antibody titer of infected persons shows a 4-fold or greater rise against the type recovered from the patient in NT. The CF test, using the common antigen, is an easily applied method for detecting infection by any member of the group. A sensitive radioimmunoassay can measure serum antibody to type 5 fiber antigen.

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