1 / 6

The pharmaceutical R&D process

10-12 years, costly ($30 Mn – $1300Mn). The pharmaceutical R&D process. Risks in research and development of pharmaceutical drugs. (Preziosi, P. 2004, Nature Reviews in Drug Discovery 3, 521-526). The pharmaceutical R&D process many different ways to innovate.

brosado
Télécharger la présentation

The pharmaceutical R&D process

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. 10-12 years, costly ($30 Mn – $1300Mn) The pharmaceutical R&D process

  2. Risks in research and development of pharmaceutical drugs (Preziosi, P. 2004, Nature Reviews in Drug Discovery 3, 521-526)

  3. The pharmaceutical R&D processmany different ways to innovate • Innovation in discovery: identifying new molecules, new drug candidates • - Basic research to understand critical pathways that can be blocked • - Development of test systems to model these pathways • - Screening of large number of molecules (=libraries) to identify « hits » • - Hit-to-lead characterisation and selection: druggability • - Lead-optimisation: more potent, better absorbed, less toxic,

  4. The pharmaceutical R&D processmany different ways to innovate • new or better uses of existing molecules / treatments

  5. Compound mining:creative utilization of existing knowledge Nitroimidazoles: rediscovered drug candidates for protozoal diseases Extensive literature / patent review, including personal consultations with researchers (previously) active on this class of compounds to uncover possible compounds of interest >600 compounds identified from >15 sources; assessed in in vitro / in vivo disease models; several series with promising activity identified 1 new drug candidate in clinical development for sleeping sickness: fexinidazole (off-patent):

  6. The pharmaceutical R&D processmany different ways to innovate

More Related