1 / 10

PHARMACEUTICAL CHEMISTRY RESEARCH PROJECTS 2013

PHARMACEUTICAL CHEMISTRY RESEARCH PROJECTS 2013. ;. RESEARCH AREAS. 1. Drug Design & Discovery (Dr. J. Joubert & Prof. S. Malan) 2. Drug Synthesis & Biological Evaluation Against pathogenic Microbes (Dr. J. Joubert & Prof S. Malan) 4. Phytochemistry (Prof P. Eagles).

cain
Télécharger la présentation

PHARMACEUTICAL CHEMISTRY RESEARCH PROJECTS 2013

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. PHARMACEUTICAL CHEMISTRY RESEARCH PROJECTS 2013 ;

  2. RESEARCH AREAS 1. Drug Design & Discovery (Dr. J. Joubert & Prof. S. Malan) 2. Drug Synthesis & Biological Evaluation Against pathogenic Microbes (Dr. J. Joubert & Prof S. Malan) 4. Phytochemistry (Prof P. Eagles)

  3. 1. Drug design and Discovery – Neuroprotective Compounds Drug design, Biological activity and physical-chemical properties. Dr. J. Joubert, Prof. S.F. Malan and co-workers

  4. Targets for Neuroprotection • Calcium homeostases • Calcium channels • NMDA receptor channels • Enzyme systems involved in neurodegeneration • Oxidative cascade, NOS and MAO-B. NOS-reaction

  5. Research within drug design • Lead compounds • Chemical synthesis, drugs in use • New compounds from plants • Molecular modeling • Synthesis and characterization • Biological activity • In vitro • In vivo

  6. Molecular modeling • Protein modeling • Receptor / Enzyme fit • ‘Ligandfit’ • ‘Docking’

  7. Synthesis and Characterisation Synthesis and characeterization with NMR, MS and IR.

  8. Biological evaluation - In vitro & In vivo

  9. 2. Synthesis of Novel/Hybrid Molecules & Biological Evaluation – Malaria and Dengue fever Inhibitory Activity Resistance reversal in Microorganisms Microscopic evaluation Molecular Studies

  10. 3. PHYTOCHEMISTRY- Prof Eagles Phytochemistry is the study of phytochemicals produced in plants, describing the isolation, purification, identification, and structure of the large number of secondary metabolic compounds found in plants. Techniques commonly used in the field of phytochemistry •Thin layer chromatography (TLC) •Gel (column chromatography) •High performance of liquid chromatography (HPLC) •Gas chromatography (GC) •Mass spectrometry

More Related