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Modeling Oscillating Neurons in Respiratory Rhythmogenesis

Modeling Oscillating Neurons in Respiratory Rhythmogenesis. Connie Oh. preBotzinger Complex: site of rhythm generation. Looking for inspiration: new perspectives on respiratory rhythm Jack L. Feldman and Christopher A. Del Negro Nature Reviews Neuroscience 7, 232-241 (March 2006).

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Modeling Oscillating Neurons in Respiratory Rhythmogenesis

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  1. Modeling Oscillating Neurons in Respiratory Rhythmogenesis Connie Oh

  2. preBotzinger Complex:site of rhythm generation Looking for inspiration: new perspectives on respiratory rhythm Jack L. Feldman and Christopher A. Del Negro Nature Reviews Neuroscience 7, 232-241 (March 2006)

  3. Hodgkin-Huxley (1952) V’ = (- 1/c) * [ iapp + gNa*m3h*(V – ECa) + gK*n4*(V – EK) + gleak*(V – Eleak) ] m’ = αm(V)(1 – m) - βm(V)(m) h’ = αh(V)(1 – h) - βh(V)(h) n’ = αn(V)(1 – n) - βn(V)(n)

  4. Fitzhugh-Nagumo (1962) є v’ = v*(v – a)(1 – v) – w w’ = v – b*w – c

  5. Morris-Lecar (1981) V’ = (-1/c) * [ iapp + gleak*(V – Eleak) + gK*w*(V - EK) + gCa*m∞(V)*(V – ECa) ] w’ = φ * [w∞(V) – w] / τw(V)

  6. Novel Model V’ = - (1/c) * [ iapp + gleak*(V – Eleak) + gNa*(V – ECa) + gK*(V – EK) + gCa*(V – ECa) + gsyn*(V – Esyn) + gton*(V – Eton) + gCa*f(Ca)*(V – ECa) ]

  7. ca0.50.40.30.20.10-0.1-0.2V0-10-20-30-40-50-60

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