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Results Highlights PowerPoint Set UK-VARSS 2017 Published October 2018

Results Highlights PowerPoint Set UK-VARSS 2017 Published October 2018. The following selected PowerPoint slides provide the core for a presentation on antibiotic sales, antibiotic use and bacterial susceptibility/resistance.

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Results Highlights PowerPoint Set UK-VARSS 2017 Published October 2018

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  1. Results Highlights PowerPoint Set UK-VARSS 2017 Published October 2018

  2. The following selected PowerPoint slides provide the core for a presentation on antibiotic sales, antibiotic use and bacterial susceptibility/resistance. These slides are based on the UK-VARSS 2017 Report which provides further details. UK-VARSS 2017 VARSS REPORT 2017 2

  3. Sales of Antibiotics Sales of antibiotics for use in food-producing animals, adjusted for animal population (mg/kg), 2013-2017 Source: p. 7 VARSS REPORT 2017 3

  4. Sales of Antibiotics Trends of antibiotic sales by highest priority critically important antibiotic for use in food-producing animals and adjusted for animal population (mg/kg), 2013-2017 * FQ: fluoroquinolones; 3/4 gen ceph: 3rd and 4th generation cephalosporins Source: p. 7 VARSS REPORT 2017 4

  5. Sales of Antibiotics Active ingredient (% tonnes) of total antibiotics sold for all animal speciesby antibiotic class, 2017 * Amphenicols, lincomycin, pleuromutilins, polymyxins (excluding colistin) and steroidal antibiotics. Source: Fig. 1.3; p. 19 VARSS REPORT 2017 5

  6. Sales of Antibiotics Total sales (tonnes) of active ingredient for all animal speciesby antibiotic class, 2017 Source: p. 7 VARSS REPORT 2017 6

  7. Sales of Antibiotics Active ingredient (mg) of antibiotic sold per kg of food-producing animal species by antibiotic class, 2013-2017 * Amphenicols, lincomycins, pleuromutilins, polymyxins (including colistin) and steroidal antibiotics. Source: Fig. 1.4; p. 20 VARSS REPORT 2017 7

  8. Sales of Antibiotics Active ingredient (mg/kg) of HP-CIAs, sold for use in food-producing animal species: 3rd/4th generation cephalosporins (), fluoroquinolones (), colistin (), 2013–2017 Source: Fig. 1.5; p. 21 VARSS REPORT 2017 8

  9. Sales of Antibiotics Combined sales of premix and oral/water antibiotic products (tonnes of active ingredient), tetracyclines, beta-lactams, trimethoprim/ sulphonamides,other*,macrolides, 2013–2017 *Aminoglycosides, fluoroquinolones, amphenicols, lincomycins, pleuromutilins, polymyxins and steroidal antibiotics Source: Fig. 1.7; p. 23 VARSS REPORT 2017 9

  10. Sales of Antibiotics Sales of injectable antibiotic products (tonnes of active ingredient), tetracyclines,  beta-lactams,  aminoglycosides,  other*,  trimethoprim/sulphonamides, 2013–2017 * Macrolides, fluoroquinolones, amphenicols, lincomycins, pleuromutilins, polymyxins and steroidal antibiotics Source: Fig. 1.8; p. 24 VARSS REPORT 2017 10

  11. Antibiotic Usage Data Antibiotic usage by food-producing animal species, 2017 compared with 2016 Source: p. 8 VARSS REPORT 2017 11

  12. Antibiotic Usage Data Antibiotic usage by food-producing animal species, 2017 compared with 2016 Source: p. 8 VARSS REPORT 2017

  13. Antibiotic Usage Data Antibiotic usage in pigs and meat poultry, 2014-2017 Source: p. 8 VARSS REPORT 2017 13

  14. Antibiotic Usage Data Usage recorded for active ingredient (mg/kg) of antibiotics in eMB Pigs by antibiotic class, 2015-2017 * Aminoglycosides, lincosamides, amphenicols, polymyxins, fluoroquinolones and 3rd and 4th generation cephalosporins Source: Fig. 2.2; p. 31 VARSS REPORT 2017 14

  15. Antibiotic Usage Data Active ingredient (mg/kg) of antibiotics used by all members of BPC Antibiotic Stewardship by species (chicken, turkey and duck) and year ( 2014,  2015,  2016,  2017) Source: Fig. 2.5; p. 33 VARSS REPORT 2017 15

  16. Antibiotic Usage Data Active ingredient (tonnes) of antibiotic used by all members of BPC Antibiotic Stewardship by antibiotic class, 2013-2017 * Lincomycins, potentiated sulphonamides, macrolides, aminoglycosides, pleuromutilins, fluoroquinolones, colistin and products under the prescribing Cascade. Source: Fig. 2.7; p. 35 VARSS REPORT 2017 16

  17. EU Harmonised Monitoring of AMR Testing carried out on E. coli isolates from pigs collected as part of the EU Harmonised Monitoring Scheme, 2017 and 2015 Source: p. 9 VARSS REPORT 2017 17

  18. EU Harmonised Monitoring of AMR Testing carried out on E. coli isolates from pigs collected as part of the EU Harmonised Monitoring Scheme, 2017 and 2015 Source: p. 9 *To note this testing does not identify the type or number of ESBLs present. VARSS REPORT 2017 18

  19. EU Harmonised Monitoring of AMR Percentage resistance (interpreted using EUCAST CBPs) in E. coli isolates from healthy pigs at slaughter, 2015 (; n=150) and 2017 (; n=186) Source: Fig. 3.1; p. 48 *Interpreted using EUCAST ECOFF values as no CBP value is available VARSS REPORT 2017 19

  20. Clinical Surveillance of AMR Resistance in Salmonella spp. from clinical surveillance, 2017 Pigs Turkeys Chickens Cattle Sheep Source: p. 10 VARSS REPORT 2017 20

  21. Clinical Surveillance of AMR Percentage of Salmonella spp. isolates susceptible to all 16 tested antibiotics, from different sources and animal species, in 2015 (), 2016 () and 2017 () * Ducks, horses, dogs, other non-avian species, other avian species, feed and farm environment Source: Fig. 4.15; p. 75 VARSS REPORT 2017 21

  22. Clinical Surveillance of AMR Percentage of resistant E.coli isolates from poultry and pigs from clinical surveillance, 2015-2017 Source: p. 10 VARSS REPORT 2017 22

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