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Agents of classical venereal infections

Agents of classical venereal infections. Institute for Microbiology, Medical Faculty of Masaryk University and St. Anna Faculty Hospital in Brno. Classical venereal infections. Gonorrhoea Neisseria gonorrhoeae Syphilis Treponema pallidum Chancroid Haemophilus ducreyi

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Agents of classical venereal infections

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  1. Agents of classical venereal infections Institute for Microbiology, Medical Faculty of Masaryk University and St. Anna Faculty Hospital in Brno

  2. Classical venereal infections • GonorrhoeaNeisseria gonorrhoeae • Syphilis Treponema pallidum • ChancroidHaemophilus ducreyi • Lymphogranuloma venereum Chlamydia trachomatis L1, L2, L2a, L3

  3. Neisseria gonorrhoeae

  4. GO: infections of the UGT ♂ • Urethritis • Epididymitis ♀ • Cervicitis • Urethritis • Bartholinitis • Endometritis • Salpingitis, adnexitis (PID, pelvic inflammatory disease) → sterility!

  5. GO: laboratory diagnostics – I Direct detection only: microscopy culture molecular biology tests Sampling places: ♂ urethra ♀ cervix, urethra, rectum, pharynx (if necessary)

  6. Ceftriaxone or ciprofloxacinusually a single dose, potential concurrent Chlamydia trachomatis: plus doxycycline or azithromycine

  7. Author: MUDr. Petr Ondrovčík

  8. The course of syphilis A) Early syphilis: primary (ulcus durum) secondary (mostly rash) early latent B) Late syphilis: latent terciary (gummas, aortitis, neurological) C) Congenital syphilis: early and late - Hutchinson´s teeth - mulberry molars

  9. Hutchinson incisors - screwdriver-shaped central incisors seen in congenital syphilis

  10. Hutchinson incisors (left) mulberry molars (right)- a first molar tooth whose occlusal surface is pitted due to congenital syphilis with nodules replacing the cusps Photo: Křemenová S, Zákoucká H, Křemen J. Problematika vrozené syfilis v posledních dvaceti letech. II. Klinický obraz. Klin mikrobiol inf lék 2006;12(2):50-57

  11. Syphilis: laboratory dg – I Direct detection From lesions (mostly ulcus durum) darkfield examination PCR immunofluorescence Indirect detection (serology) with nonspecific antigen (cardiolipin) with specific antigen (Treponema pallidum)

  12. Syphilis: laboratory dg – II Nontreponemal: RRR, VDRL, RPR biologically fals positive Treponema : TPHA, ELISA, WB, FTA-ABS,TPIT sensitive, specific, positive for life

  13. Poster, 1940

  14. Screening: cardiolipin test (RPR) + TPHA

  15. Gerrit van Honthorst (1590-1656): Dentist (1622)

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