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  1. WHO reviewofevidence on healthaspectsofairpollutionfortherevisionofthe EU airpoliciesMarie-Eve Heroux, Michal Krzyzanowskiand Hans-Guido Mücke**WHO CollaboratingCentrefor Air Quality Management and Air Pollution Controlatthe Federal Environment Agency, Berlin/Germany 18th EINOET workshop, 24/25 October 2013 in Dublin

  2. Review of evidence on health aspects of air pollution / REVIHAAP and HRAPIEWHO/EC funded both projects REVIHAAP and HRAPIEFrom Sept 2011 to Spring 2013Development of answers to 26 key policy questions on:Particulate matter PM2.5 and PM10 (7 questions)Ground-level ozone (4 questions)Other air pollutants (NO2, SO2, metals, PAHs) and their mixtures (10 questions)General questions 18th EINOET workshop, 24/25 October 2013 in Dublin

  3. Review of evidence on health aspects of air pollution / REVIHAAP and HRAPIE-> General questionsImpact on revision of EU policies and/or need to revise WHO AQGEmerging issues on health risks from air pollutionEvidence of health benefits from reduction of air pollutionEvidence of threshold for PM, O3, and NO2Identification/development of concentration-response functions (CRFs) to be included in cost-benefit analysis 18th EINOET workshop, 24/25 October 2013 in Dublin

  4. 1. WHO-EU project „Review ofEvidence on HealthAspectsof Air Pollution – REVIHAAP“ (2011 - 2013) - WHO project jointly financed by WHO and EC, managed by WHO/ECEH, Bonn office (Marie-Eve Heroux)- Evidence review in response to 24 key policy questions from the EC, predominantly concerning NO2, O3 and PM - Timing: 20 months, Sept 2011 – April 2013- Steering Advisory Committee (8 experts, multiple TCs)- Review of evidence and drafting the answers: 29 experts- External review: 30 experts- Two expert meetings (Aug 2012 & Jan 2013)- Full rationales published in June 2013- Followed by a sister project: “Health risks of air pollution in Europe – HRAPIE” - health risk assessment, emerging issues 18th EINOET workshop, 24/25 October 2013 in Dublin

  5. 1.1 REVIHAAP: selectedconclusions on PM healtheffects 1/2New studies on short- and long-term effectsLong-term exposures to PM2.5 are a cause of cardiovascular mortality and morbidity 8th CAPPA conference, 12 September 2013 in Sibenik/Croatia

  6. 1.1 REVIHAAP: selectedconclusions on PM healtheffects 2/2Both short term (such as 24h averages) and long term (annual mean) exposure to PM2.5 affects health (A5) More insight on physiological effects and plausible biological mechanisms linking short- and long-term PM2.5 exposure with mortality and morbidityStudies linking long-term exposure to PM2.5 to several new health outcomes (e.g. atherosclerosis, adverse birth outcomes, childhood respiratory disease). 18th EINOET workshop, 24/25 October 2013 in Dublin

  7. 1.2 REVIHAAP: selectedconclusions on ozone (B1)New evidence for an effect of long-term exposure to ozone on:respiratory (and cardiorespiratory) mortality (ACS study);mortality among persons with potentially predisposing conditions (COPD, diabetes, congestive heart failure, and myocardial infarction); asthma incidence, asthma severity, hospital care for asthma and lung function growth. 18th EINOET workshop, 24/25 October 2013 in Dublin

  8. 1.2 REVIHAAP: selectedconclusions on ozone, cont.Adverse effects of exposure to daily ozone concentrations (maximum daily 1-hr or 8-hr mean) on: all-cause, cardiovascular and respiratory mortality; respiratory and cardiovascular hospital admissions.The evidence for a threshold for short-term exposure is not consistent, but where a threshold is observed, it is likely to lie below 45 ppb (90 µg/m3) (max 1-hr). (B2) 18th EINOET workshop, 24/25 October 2013 in Dublin

  9. 1.3 REVIHAAP: selectedconclusions on NO2 (C2-3,D1)New studies document associations between day-to-day variations in NO2 and variations in mortality, hospital admissions, and respiratory symptoms;New studies showing associations between long-term exposure to NO2 and mortality and morbidity; Both short- and long-term studies have found these adverse associations at concentrations that were at or below the current EU LV (= WHO AQG); 18th EINOET workshop, 24/25 October 2013 in Dublin

  10. 1.3 REVIHAAP: selectedconclusions on NO2 (C2-3,D1)The associations between NO2 and short-term health effects in many studies remain after adjustment for other pollutants (including PM10, PM2.5, black smoke).… it is reasonable to infer that NO2 has some direct effects.No evidence to suggest changing the averaging time for the short-term EU limit value (1-hour) (D1) 18th EINOET workshop, 24/25 October 2013 in Dublin

  11. 1.4 REVIHAAP: selectedconclusions on total exposureElevated health risks associated with living in close proximity to roads is unlikely to be explained by PM2.5 mass. (C1) In theabsenceoftobacco smoke:Ambient air, indoor sources and commuting are all important for population exposures to NO2 (where gas appliances are frequent), benzene and naphthalene;The high end of the individual exposures to PM10-2.5 and naphthalene originate from indoor sources and commuting; Solid fuel fired indoor fireplaces and stoves, where used in suboptimal conditions, dominate the high end of the exposures to PM2.5, BC, UFP, CO, benzene and BaP of the affected individuals. 18th EINOET workshop, 24/25 October 2013 in Dublin

  12. 1.5 REVIHAAP: criticaldatagaps (A7/C9) – selectedconclusions on healtheffectsstudiesMore epidemiological studies to update E-R functions based on meta-analyses for integrated risk assessment; The coordinated application of atmospheric science, epidemiological, controlled human exposure and toxicological studies to advance understanding of the: sources responsible for the most harmful emissions, physical–chemical composition of the pollution, biological mechanisms that lead to adverse effects on health; 18th EINOET workshop, 24/25 October 2013 in Dublin

  13. 1.5 REVIHAAP: criticaldatagaps (A7/C9) – selectedconclusions on healtheffectsstudies, cont.Air pollution should be considered to be one complex mix, and conditions under which this mix has the largest effect on human health need to be identified; Advances in atmospheric modelling, in conjunction with validation studies that use targeted monitoring campaigns, will provide a more efficient way forward in research on health effects, rather than relying on increasing the number of components measured by routine monitoring networks. 18th EINOET workshop, 24/25 October 2013 in Dublin

  14. 1.6 REVIHAAP: Main conclusionsConsiderable amount of new scientific information on health effects of PM, O3 and NO2 observed at levels commonly present in Europe, has been published in the recent years. It: supports the scientific conclusions of the WHO Air Quality Guidelines updated in 2005; indicates that the effects can occur at air pollution concentrations lower than those serving to establish the 2005 Guidelines; provides scientific arguments for the decisive actions to improve air quality and reduce the burden of disease associated with air pollution in Europe. 18th EINOET workshop, 24/25 October 2013 in Dublin

  15. 2. EU-WHO project „HealthRisksof Air Pollution in Europe – HRAPIE“ (2013) 2.1 Aim of the project- to assess the views of stakeholders and experts to identify emerging issues on health risks from AP, either related to specific source categories (e.g. transport, biomass combustion, metal industry, refineries, power production), specific gaseous pollutants or specific components of PM (e.g. size-range like nano-PM and UFP, raw earth metals, BC) 18th EINOET workshop, 24/25 October 2013 in Dublin

  16. 2. EU-WHO project „HealthRisksof Air Pollution in Europe – HRAPIE“ (2013) 2.2 Methods- development of an electronic survey tool by WHO-ECEH (M-E Heroux, G Chan) and Dublin Institute for Technology/DIT (S Henschel and P Goodman); pilot tested- disseminated by WHO-ECEH spring 2013 (May/June)- 15 questions for app. 15 minutes: 11 per indentified risk; 4 on demographic aspects- survey responses were analysed collectively for trends- WHO report is under preparation; to be published in 2013 18th EINOET workshop, 24/25 October 2013 in Dublin

  17. 2. EU-WHO project „HealthRisksof Air Pollution in Europe – HRAPIE“ (2013) 2.3 Main findings - 113 questionnaires returned- Emerging risks identified (i) may only recently be identified or (ii) may have existed for a long time, but only recently their significance or importance is coming to the fore- the top 6 emission sources categories (out of total of 16 categories) posing an emerging health threat: road transport: 40.7%; space heating: 15%; shipping: 8.8%; energy production: 6.2%, metal industries: 6.2%; agriculture: 5.3% 18th EINOET workshop, 24/25 October 2013 in Dublin

  18. 2. EU-WHO project „HealthRisksof Air Pollution in Europe – HRAPIE“ (2013) 2.4 Other key observations- strong signal for ‘metal’ components for a number of source categories- strong signal for ‘smaller’ PM, esp. PM2.5 and UFP- concern for the increase in prevalence of certain sources, and growth in exposed population- cardiovascular, respiratory, cancer and neurobehavioral effects have been identified as key AP health impacts 18th EINOET workshop, 24/25 October 2013 in Dublin

  19. 2. EU-WHO project „HealthRisksof Air Pollution in Europe – HRAPIE“ (2013) 2.5 Conclusion- limited response rate due that the electronic survey could be accessed four weeks only- length of questionnaire was probably to long, and discouraged respondents- 15 questions for app. 15 minutes: 11 per indentified risk; 4 on demographic aspects- survey responses were analysed collectively for trends- WHO report is under preparation; to be published in 2013 18th EINOET workshop, 24/25 October 2013 in Dublin

  20. 2. EU-WHO project „HealthRisksof Air Pollution in Europe – HRAPIE“ (2013) 2.6 Further HRAPIE tasks- Reply the EC question: “What concentration-response functions for key pollutants should be included in cost-benefit analysis supporting the revision of EU air quality policy?”- Follow recommendations of the HRAPIE project concerning CRFs for the pollutant-health outcome pairs. Thanks for your attention! 18th EINOET workshop, 24/25 October 2013 in Dublin

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