A Knowledge Based Economy (KBE) * Money, Time and Talent !

1. AKnowledge Based Economy (KBE)* Money, Time and Talent ! Building History | KBE | Biomed | S&E | Talent | Enterprise

2. Map of Singapore: Location of one-north Nanyang Technological University Changi Airport one-north Biopolis National University of S’pore National University Hospital Fusionopolis Tuas Biomedical Park City Centre SGH Jurong Island Seaport & Container Terminals

3. Innovator of new products & services Knowledge- Intensive Technology-intensive Capital-intensive Skills-intensive Labour-intensive Singapore’s Economic Progress Keep moving up ! History | KBE | Biomed | S&E | Talent | Enterprise

4. The Turning Point S$14,345 (1986) 1985/6 Recession 1987 Recovery GDP Per capita (S$) Independence 1965 1985: Economy shrank 1.5% 1985: 4% unemployment 1986: 7% unemployment S$ 1,567 (1965) History | KBE | Biomed | S&E | Talent | Enterprise

5. S$46,832 (2006) 50,000 45,000 40,000 35,000 30,000 25,000 GDP Per capita (S$) 20,000 15,000 10,000 5,000 0 1965 1970 1975 1980 1985 1990 1995 2000 2005 Independence 1965 S$14,345 (1986) S$ 1,567 (1965) 1986: Economy grew 2% 1987: Economy grew 9% 1988: 20,000 new jobs created History | KBE | Biomed | S&E | Talent | Enterprise The UpTurn

6. Building the Data Storage Industry Cluster Cumulative Output (1986-2000): S$170 billion S$20 billion (1997) S$11 billion (2006) S$2.4 billion (1986)

7. Building the Semiconductor Industry Cluster Cumulative Output (1986-2000): S$122 billion S$36 billion (2006) 40,000 30,000 S$11 billion (1998) 20,000 S$2.3 billion (1986) 10,000 0 1986 1988 1990 1992 1994 1996 2004 2006 1998 1980 1982 1984 2000 2002

8. Building The Chemicals Industry Cluster S$76 billion (2006) Cumulative Output (1986 – 2000) - S$266 billion S$ Million 60,000 Official Opening of Jurong Island 50,000 (S$32 billion) 1995 Construction started on Jurong Island (S$17 billion) 40,000 30,000 20,000 10,000 1986 1988 1990 1992 1994 1996 1998 2000 2002 2004 2006 History | KBE | Biomed | S&E | Talent | Enterprise

9. The Jurong Island Story 1991 present These seven tinyislands (800 ha in all) then became ….. … a 3,400 ha single island History | KBE | Biomed | S&E | Talent | Enterprise

10. Jurong Chemical Island ….Today Jurong Island Today … a 3,400 ha single island

11. Manufacturing Construction Wholesale & Retail Trade Transport & Storage Hotels and Restaurants Information & Communications Financial Services Business Services Other Services Others 2006 GDP Pie (S$210 billion) 5.2% (Others) 10.2% (Other Services) 27.7% (Manufacturing) MANUFACTURING 11.5% (Business Svcs) 3.6% (Construction) 11.2% (Financial Svcs) 3.8% (Info & Comms) 15.2% (Wholesale &Retail Trade) 1.9% (Hotels & Restaurants) 9.6% (Transport &Storage) History | KBE | Biomed | S&E | Talent | Enterprise

12. Manufacturing Total Manufacturing Output of 4 key clusters : $235 billion (2006) S$ Million 100,000 Electronics 80,000 Chemicals 60,000 40,000 Precision Engrg 20,000 Biomedical Sciences 0 1986 1988 1990 1992 1994 1996 1998 2000 2002 2004 2006p Chemicals BMS Electronics (incl Data Storage and Semiconductors) Precision Engrg History | KBE | Biomed | S&E | Talent | Enterprise

13. Manufacturing Person 140000 120000 100000 80000 60000 40000 20000 Total Employment in 4 clusters : 223, 277 (2006) Electronics Precision Engrg Chemicals Biomedical Sciences 0 1986 1988 1990 1992 1994 1996 1998 2000 2002 2004 2006p Electronics Chemicals BMS Precision Engrg History | KBE | Biomed | S&E | Talent | Enterprise

14. Creation of 4 clusters of growth Singapore has promoted and attracted 4 waves of investments: - * Data storage (1986-1990) * Semiconductors (1991-1995) * Chemicals (1996 to 2000) * Biomedical industries (2001 to 2006)

15. Four Industry Waves (1986 to 2006) Data Storage S$170 b Semiconductors S$122 b Chemicals S$266 b Biomedical Sciences S$125 b History | KBE | Biomed | S&E | Talent | Enterprise

16. Where do we go from here? High Growth Stagnation GDP Per capita (S$) Technology Intensive Capital Intensive Skills Intensive Decline Labour Intensive History | KBE| Biomed | S&E | Talent | Enterprise

17. Moving forward to a Knowledge Based Economy model 1965 – 1978: Export Oriented Industrialisation 1979 – 1985: Industrial Restructuring 2001 onwards: Transforming to Knowledge-Based Economy 1986 – 2000: Capability Building and Economic Diversification History | KBE | Biomed | S&E | Talent | Enterprise

18. From Manufacturing to Knowledge-Based Economy • An Economy based on cost efficiency is not sustainable in the long term • Move up the Value chain with focus on high value-added activities • Graduate Education is a necessity for high value-added R&D-oriented industries • Research  Development  Production  Marketing  Distribution  Servicing History | KBE | Biomed | S&E | Talent | Enterprise

19. What is a Knowledge-Based Economy? Create, Own + Exploit (COE) Knowledge • How do we create knowledge and useful ideas? R&D and innovation. • Where? New high growth areas like biomedical sciences, nanotechnology, energy. • Why? R&D generates intellectual property (IP) and this is the “real value-added” R&D complements our manufacturing core. Coupling the two will create clusters of high value-added activity. History | KBE | Biomed | S&E | Talent | Enterprise

20. Biomedical Research Council Science and Engineering Research Council Exploit Technologies Corporate Planning and Administration A*STAR Graduate Academy Building up the R&D foundation (2001) History | KBE | Biomed | S&E | Talent | Enterprise

21. A*STAR’s Foundations Research governance framework • Established Research Councils and RI Scientific Advisory Boards Research Infrastructure • Completed Biopolis Phase 1 & Phase 2 Focus on Talent • Attracted international scientific leaders and scientists • Set up A*STAR Graduate Academy to groom Singaporean PhD talent Encourage Commercialisation • Streamlined Intellectual Property policies • Established Commercialisation of Technology Fund International Partnerships • Partnerships for research collaboration and graduate education/training History | KBE | Biomed | S&E | Talent | Enterprise

22. A snapshot of Singapore’s current R&D scene History | KBE | Biomed | S&E | Talent | Enterprise

23. International Comparison of R&D Intensity Singapore’s Goal: 3.0% by 2010Limit: TALENT 4 3.5 Finland Japan 3 R&D / GDP % Korea United States Taiwan 2.5 Singapore 2.36% (2005) Total OECD 2 Singapore 1.88% (2000) 1.5 Ireland 1 2000 2001 2002 2003 2004 2005 Year Source: National Survey of R&D in Singapore 2005 and OECD MSTI 2006_1 History | KBE | Biomed | S&E | Talent | Enterprise

24. Building up R&D Human Capital 2000 - 2006 28000 130 26000 110 24000 22000 90 20000 70 18000 16000 50 14000 30 12000 10000 10 2000 2001 2002 2003 2004 2005 2006 No. of research manpower No. of research manpower per 10,000 labour force RSE per 10,000 Research Scientists and Engineers (RSE) History | KBE | Biomed | S&E | Talent | Enterprise

25. No. of Patents Applied / Awarded 2200 2000 1800 1600 1400 1200 1000 800 600 400 200 0 2000 2001 2002 2003 2004 2005 2006 Patents applied Patents awarded Goal History | KBE | Biomed | S&E | Talent | Enterprise

26. Building up Biomedical Sciences 2001 A*STAR History | KBE| Biomed | S&E | Talent | Enterprise

27. Basic, Translational & Clinical Research Product & Process Development Pilot & Commercial Manufacturing Regional HQ & Shared Services Healthcare Delivery Vision Singapore – The Biopolis of Asia An International Biomedical Sciences Cluster Advancing Human Health Through the Pursuit of Excellence in Research & Development, Manufacturing, and Healthcare Delivery History | KBE| Biomed | S&E | Talent | Enterprise

28. Biomedical Sciences Value Chain S*BIO Research Development Manufacturing HealthcareServices Human Capital Development Intellectual Capital Development Industrial Capital Development History | KBE| Biomed | S&E | Talent | Enterprise

29. How It All Started…. Prof. John Wong A/Prof. Kong Hwai Loong 26thJune 2000 Prof. Tan Chorh Chuan

30. Dr Sydney Brenner The Salk Institute (USA) Dr David Baltimore (Emeritus) California Institute of Technology (USA) Dr Leland Hartwell Fred Hutchinson Cancer Research Center (USA) Dr Stanley N. Cohen (Emeritus) Stanford University (USA) Dr Susan Lindquist (Emeritus) Whitehead Institute of Biomedical Research (USA) Dr David I. Hirsh (Emeritus) Columbia University (USA) Dr Peter Gruss Max Planck Society (Germany) Dr Paul A. Marks (Emeritus) Memorial Sloan-Kettering Cancer Center (USA) Dr John Bell University of Oxford (UK) Dr Alan Munro (Emeritus) University of Cambridge (UK) Dr Richard Lerner (Emeritus) Scripps Research Institute (USA) Dr Alan Bernstein (Emeritus) Canadian Institutes of Health Research (Canada) Dr Colin Blakemore Medical Research Council (UK) Sir Keith Peters (Emeritus) GlaxoSmithKline (UK) Dr John Reed (Emeritus) Burnham Institute (USA) Dr Harriet Wallberg-Henriksson Karolinska Institutet (Sweden) Dr Hans Wigzell (Emeritus) Karolinska Institutet (Sweden) Dr Axel Ullrich (Emeritus) Max-Planck Institute of Biochemistry (Germany) Dr Suzanne Cory WEHI (Australia) Dr John Shine (Emeritus) Garvan Institute of Medical Research (Australia) Dr William Evans St Jude (USA) Dr Philippe Kourilsky (Emeritus) College de France (France) Dr Helen Hobbs UT Southwestern (USA) Sir George Radda(Emeritus) University of Oxford (UK) Dr Anthony Pawson Samuel Lunenfeld Research Institute (Canada) BMS International Advisory Council Sir Richard Sykes (Chairman) Imperial College (UK) Dr John Mendelssohn (Co-Chairman) MD Anderson (USA) Dr Samuel Barondes (Emeritus) University of California, San Francisco (USA) Dr Tadataka Yamada Gates Foundation (USA) Dr Rolf Zinkernagel University of Zurich (Switzerland) Sir Philip Cohen University of Dundee (UK)

31. Breaking New Ground in 2001 … Biopolis History | KBE| Biomed | S&E | Talent | Enterprise

32. Biopolis 1 Biopolis 2 Biopolis • Biopolis Phase 1 • All 5 BMRC Research Institutes • S&T offices (British High Com and RIKEN) • Corporate labs (NITD, GSK) • 185,000 square metres • Officially opened on October 2003 • Biopolis Phase 2 • BMRC Research Institutes • Corporate labs • Additional 37,000 square metres • Officially opened on 30 October 2006

33. BMRC Research Institutes Institute of Molecular and Cell Biology (IMCB) Bioprocessing Technology Institute (BTI) Institute of Medical Biology (IMB) Bioinformatics Institute (BII) Genome Institute of Singapore (GIS) Institute of Bioengineering & Nanotechnology (IBN) Singapore Institute for Clinical Sciences (SICS) History | KBE| Biomed | S&E | Talent | Enterprise

34. Integrated Infrastructure: Tuas Biomedical Park Phase 2 • 37,000 sqm • Opened on 30 October 2006 Biopolis Tuas Biomedical Park Phase 4 Phase 3 • Tuas Biomedical Park I & II • 360 Ha of prepared industrial land • Ready infrastructure provided • - Stable water, Electricity, • Telecommunications, • Sewerage discharge Shared Facilities • Shared R&D equipment • Shared animal facility Phase 1 • 185,000 sqm • S$500 million invested • Public & corporate R&D labs • > 95% of space committed History | KBE| Biomed | S&E | Talent | Enterprise

35. Biomedical Sciences (BMS) Manufacturing Performance 1986-2006 $ ‘000 Cumulative Output (1986 – 2006) - S$125 billion S$23 billion (2006) 25,000 20,000 15,000 Output S$6 billion (2000) 10,000 5,000 0 1996 1998 2006 1992 1994 2004 1990 2000 1986 1988 2002 Manufacturing Output Value-Added History | KBE| Biomed | S&E | Talent | Enterprise

36. 12000 10000 8000 6000 4000 2000 0 2002 2004 2006 1990 1992 1994 1996 1998 2000 1986 1988 Biomedical Sciences (BMS) Actual Employment 1986 - 2006 10,572 (2006) 5,880 (2000) Employment History | KBE| Biomed | S&E | Talent | Enterprise

37. Biomedical Cluster Map CLINICAL RESEARCH MEDICAL TECHNOLOGY PHARMACEUTICALS Drug Discovery Bioimaging Bioprocessing Chemical Synthesis Industry Sectors Genomics & Proteomics Industry Sectors Molecular & Cell Biology Bioengineering & Nanotechnology Cohort Studies Biomarkers Stem cells Computational Biology HEALTHCARE SERVICES & DELIVERY BIOTECHNOLOGY TRANSLATIONAL RESEARCH History | KBE| Biomed | S&E | Talent | Enterprise

38. Research Institutes • IMCB, GIS, BTI • IBN, BII, • CMM, SICS Academic BENCH NUS,NTU Co-investment, VC funding RISC grants, infrastructure, tax breaks INDUSTRY Overseas Clinical Trials MEaT Biotech Clinical Trials Pharma Singapore Clinical Trials Biologics (cells / vaccines) Drug discovery & devt Med tech / devices Translational / Investigational Medicine Mission-oriented BENCH BEDSIDE NMRC / HSA • Clinical Research Programmes • Focus, strategy Set up by A*STAR / BMRC • Human Capital • Development, recruitment STN Research Consortia SCS • SIgN • Biomarkers • Infrastructure • For Clinical Trials DPF Office • SBIC • SSCC SCCS • Regulatory Framework • IRBs MBBS PhD / BMS IF / CSI awards SIgN = Singapore Immunology Network SSCC = Singapore Stem Cell Consortium STN = Singapore Tissue Network SCS = Singapore Cancer Syndicate SCCS = Singapore Consortium of Cohort Studies DPF = Data Privacy Framework BMS IF = Biomedical International Fellowship CSI = Clincian Scientist Investigatorship IRBs = Institutional Review Boards MEaT = Medical Enginering and Technology IMCB = Institute of Molecular & Cell Biology GIS = Genome Institute of Singapore BTI = Bioprocessing Technical Institute IBN = Institute of Bioengineering and Nanotechnology BII = Bioinformatics Institute CMM = Centre for Molecular Medicine SICS = Singapore Institute for Clinical Sciences SBIC = Singapore Bioimaging Consortium

39. Basic BIOMEDICAL RESEARCH Translational Clinical A*STAR Biomedical Research Ministry Of Health National Healthcare Group • National University Hospital • The Cancer Institute • Tan Tock Seng Hospital • Communicable Disease Centre • National Skin Centre • Singapore Institute for • Clinical Sciences (SICS) • Develop programmes in • Translational Clinical Medicine • Develop critical resources: • Singapore Tissue Network • Singapore Consortium of • Cohort Studies • Develop Clinician Scientists: • Clinician Scientist • Investigatorship (CSI) Awards • PhD training for medical • doctors • Biomedical International • Fellowships Institute of Medicinal Biology (IMB) CMM @ Biopolis (2006 -2008) • Singapore Oncogenome Group • Regenerative Medicine • Epithelial Biology • Research Institutes • Institute of Molecular & Cell Biology • Genome Institute of Singapore • Institute of Bioengineering & Nanotechnology • Bioprocessing Technology Institute • Bioinformatics Institute Singapore Health Services • Singapore General Hospital • National Cancer Centre • National Heart Centre • Singapore National Eye Centre • KK Women and Children’s Hospital • National Neuroscience Institute • MOH HQ • - Ethical regulations/framework for clinical research e.g. IRBs • NMRC • Clinical research strategy • Grant management • Manpower development • HSA • Evaluation capabilities for new technologies Consortia • Singapore Cancer Syndicate • Singapore Bioimaging Consortium • Singapore Stem Cell Consortium • Singapore Immunology Network • Member of Intl Cancer Biomarker Consortium SICS @ Kent Ridge • Genetic Medicine • Virology/Infectious Diseases SICS @ Outram (2008-2010) • Cardiovascular Diseases • Eye Diseases Extramural Grants UNIVERSITIES

40. Hub for Clinical Trials & Regional Management Local: Early Phase and Complex Trials Bristol-Myers Squibb Company • 8 emp • Phase 3 Trials • Results Used in NDA Submission • GSK and GSK Biologicals • 42 emp • Phase 2-4 Trials • 22 emp • Phase 2-4 Trials • Data Management • 32 emp • Phase 2-4 Trials • 12 emp • Phase 2-3 Trials • Centralized Data • 6 emp • Phase 2-3 Trials • Results Used in NDA Submission • 4 emp • Phase 2-4 Trials • Data Management • 10 emp • Phase 2-4 Trials LILLY • 65 emp • 31 bed Phase 1 Unit • Japan Bridging Studies • 20 emp • 28 Bed Phase 1 Unit • Phase 3-4 Trials • 10 emp • Phase 3-4 Trials • 14 emp • Phase 1-4 Trials History | KBE| Biomed | S&E | Talent | Enterprise

41. Fusion of Science and Engineering History | KBE| Biomed | S&E | Talent | Enterprise

42. Science & Engineering Industry Clusters Science and Engineering Cluster Map Communications Software & Computing Data Storage Advanced Display Digital Content & Media Electronic Components Microelectronics Devices Electronic Modules Computational Science Manufacturing Technology Material Science & Engineering Precision Components Infocomm Research Precision Modules Chemical Sciences Machinery & Systems Specialty Chemicals Aerospace Performance Materials Marine & Offshore Petroleum/Petrochemicals Automotive Bio & Consumer Chemistry ELECTRONICS INFOCOMM IME DSI I2R Semiconductors Storage & Peripherals IMRE ICES SIMTech IHPC Process Engineering * CHEMICALS ENGINEERING Alignment of SERC RIs to meet Industry Needs History | KBE| Biomed | S&E | Talent | Enterprise

43. Developing New Competencies Advanced Display Communications Nano-elect. Electronic Components Software & Computing Polymer Elec. Electronic Modules Digital Content & Media Semiconductors Photonics Devices Storage & Peripherals Specialty Chemicals Performance Materials Petroleum/Petrochemicals Bio & Consumer Chemistry Process Engineering ELECTRONICS INFOCOMM Imaging Ultra wide Band Data Storage Home 2015 MicroElectronics Info-Comm Sciences Materials Sciences Chemical Sciences Human-factor Engineering Nanotechnology Manufacturing Technology Human-machine interface Arrayed sensor networks Precision Components Precision Modules Sensors Synthetic Chemistry Machinery & Systems Mfg Systems Aerospace Offshore Engrg ENGINEERING CHEMICALS Energy History | KBE| Biomed | S&E | Talent | Enterprise

44. SERC Research Institutes Data Storage Institute (DSI) Institute of Micro-electronics (IME) • Singapore Institute of Manufacturing Technology (SIMTech) Institute for Chemical & Engineering Sciences (ICES) • Institute of High Performance Computing (IHPC) Institute of Materials Research & Engineering (IMRE) • Institute for Infocomm Research (I2R) History | KBE| Biomed | S&E | Talent | Enterprise

45. Attracting and Anchoring Corporate R&D activities SERC RIs initiated 838 Industry R&D projects from FY01-FY06* * As of 31st December 2006 History | KBE| Biomed | S&E | Talent | Enterprise

46. Fusionopolis – Home for Integration of Technologies and Capabilities Systems / Applications (I2R) Platform (SIMTech / IME) Technologies System Integration (SIMTech) Computer Modeling (IHPC) Devices (IME, DSI) Materials (IMRE) Chemistry (ICES) Central Facilities History | KBE| Biomed | S&E | Talent | Enterprise

47. Fusionopolis Phase 1 Facilities SERC, CPAD, ETPL, I2R, IHPC, DSI (network storage), SIMTech (Industrial Informatics) located at Fusionopolis Phase 1 History | KBE| Biomed | S&E | Talent | Enterprise

48. Realising Fusionopolis A Magnet for the Best and Brightest Outstanding researchers with diverse cultures to create highly inventive environment Bringing Technology From the labs to Your Daily Experience experimental place to innovate and create ideas for R&D and new applications Singapore’s most powerful Computers - driving innovations Science meets business Partnering industry in joint development of next generation technologies Small Matters! produce high-resolution, 3D images down to an atomic level S'pore's largest R&D cleanroom at your service State-of-the-art cleanroom Area of Phase 1 : 120,000m2 Area of Phase 2 : 103,688m2 No. of Researchers : > 1600 Integration of SERC RI Capabilities

49. One-North

50. FUSIONpolis – Aerial view Co-location of Fusionopolis and Biopolis Circle line MRT History | KBE| Biomed | S&E | Talent | Enterprise