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GBS Lymphocyte Biology

GBS Lymphocyte Biology. When is the class? Monday, Wednesday, Friday 8am Shelby 105 There is no class on Monday January 17 th , but class will instead be held on Tuesday January 18 th . The last class is on January 28 th. What will be covered in the class?.

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GBS Lymphocyte Biology

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  1. GBS Lymphocyte Biology When is the class? Monday, Wednesday, Friday 8am Shelby 105 There is no class on Monday January 17th, but class will instead be held on Tuesday January 18th. The last class is on January 28th

  2. What will be covered in the class? • Each week a different topic related to lymphocyte biology will be covered • The material covered will be based on papers with some reviews for background information.

  3. How is the class formatted? • Each paper will be introduced by an assigned student. The student should clearly outline the rationale for the study and basically overview why the work was initiated. • The assigned student will present the first figure of the paper and is also responsible for preparing powerpoint slides of ALL OF THE OTHER FIGURES from the paper.

  4. What happens after figure 1? • After the paper has been introduced we will randomly pick students to present the remaining figures and tables (typically one student for each display item). • You should emphasize why the experiment was performed, how it was done, how it fits in with the rest of the report and also give the authors’ as well as your own conclusions about the data shown.

  5. DISCUSSION!! • All students are expected to read all of the papers. • Students are expected to actively ask questions and participate in a lively discussion of the figures, papers and topic. • You will get out what you put in!

  6. Where can I find the papers? http://www.microbio.uab.edu/lymphocyte_biology/index.html

  7. Assignments

  8. What if I have questions about the class? Allan Zajac (azajac@uab.edu) Chander Raman (Chander.Raman@ccc.uab.edu) Harry Schroeder (hwsj@uab.edu) Laurie Harrington (lharring@uab.edu)

  9. What do you know about CD8 T cell responses?

  10. T cells recognize MHC + peptide CD4+ T cell CD8+ T cell     TCR TCR CD8 CD4 Peptide Peptide 1 1 2 1 2 2 3 ß2-microglobulin MHC Class I MHC Class II Target Cell APC

  11. CD8+T cell CD4+T cell  DENDRITIC CELL   CD8+T cell ~  CYTOTOXICITY ~ ~ Cytokines 

  12. Three phases of the CD8 T cell response: Expansion, Contraction, and Maintenance 107 GP33 NP396 GP276 106 NP205 Number of Tetramer+ CD8 T Cells/Spleen 105 104 0 100 200 500 Days Post Infection

  13. ? ? e e e e e e e e e e m m m m m n n How is T cell memory generated? naive effector memory

  14. Short-Lived Effector or Exhausted CD8 T cell differentiation Tbet Blimp-1 Eomes IL-2 Production Proliferative Capacity CD127 Differentiation Memory Precursor Tbet Blimp-1 Eomes IL-2 Production Proliferative Capacity CD127

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