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肢体远距缺血预处理在心肌缺血损伤中具有线粒体保护作用

“生理科学实验”之研究性实验汇报. 肢体远距缺血预处理在心肌缺血损伤中具有线粒体保护作用. 医学院 01 级 基础医学专业 沈方 沈倩 许震宇 指导教师：夏强 高琴 陆源. BACKGROUND. 肢体局部组织短暂性缺血 心肌保护效应. 线粒体. 远距离预处理. 调控细胞“生死”的关键. ？. 心肌保护效应. 线粒体. 远距离预处理. METHODS. 远端缺血预处理. 离体心脏缺氧. 分离线粒体. 测量吸光度的改变. Specific procedures. RESULTS. A bsorbance change.

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肢体远距缺血预处理在心肌缺血损伤中具有线粒体保护作用

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  1. “生理科学实验”之研究性实验汇报 肢体远距缺血预处理在心肌缺血损伤中具有线粒体保护作用 医学院 01级 基础医学专业 沈方 沈倩 许震宇 指导教师：夏强 高琴 陆源

  2. BACKGROUND 肢体局部组织短暂性缺血 心肌保护效应 线粒体 远距离预处理 调控细胞“生死”的关键 ？ 心肌保护效应 线粒体 远距离预处理

  3. METHODS 远端缺血预处理 离体心脏缺氧 分离线粒体 测量吸光度的改变

  4. Specific procedures

  5. RESULTS Absorbance change Remote Preconditioning of the lower limb can prevent mitochondria swelling

  6. A’520 reduction **P < 0.01vs.Control A’520=A520/A520Max

  7. MDA production Not enough data for statistical analysis

  8. Conclusion • 远距离缺血预处理可在心肌缺血损伤过程中保护线粒体 • 远距离缺血预处理可减轻心肌缺血过程中的脂质过氧化水平 • 线粒体可能是远距离缺血预处理所产生的各种心肌保护因素的重要靶点

  9. Possible mechanism Ischemia RPC Ca2+ Humour factors Nervous factors Mitochondria swelling Mitochondria keeps intact Oxidants (ROS) other targets ？ Necrosis ATP Cyto C release Cardioprotective effect Apoptosis

  10. Perspective • 进一步明确参与RPC保护作用的各种神经体液因素 • 探讨各种因素是如何作用于线粒体并产生相应效应 • 阐明RPC保护效应的内在机制

  11. Thank you! 2005.1.11

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