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Tangential Flow Filtration Solutions

Spectrum’s mission is to provide quality Membrane Separations Technology to the Life Science market. Tangential Flow Filtration Solutions. Tangential Flow Filtration Shanghai, Oct. 26, 2011. Yingqing Huang, General Manager for Greater China. Overview. Introduction to TFF Applications

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Tangential Flow Filtration Solutions

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  1. Spectrum’s mission is toprovide quality Membrane Separations Technology to the Life Science market

  2. Tangential Flow Filtration Solutions Tangential Flow Filtration Shanghai, Oct. 26, 2011 Yingqing Huang, General Manager for Greater China

  3. Overview • Introduction to TFF • Applications • Challenges • Our Offerings • Membranes, mPES, • System, KRIIi • Single Use Technology • Designed for Scalability • Summary

  4. Hollow Fiber TFF • Effective Reduction of Membrane Fouling • Tubular Membrane Geometry • Large Surface Area in a Compact Size • Gentle Separations with • Relatively Low Pressure • Available in UF and MF pore size ranges • Directly Scalable by • Increasing Number of Fibers

  5. Applications • Alternatives to centrifugation, depth filtration, etc. • Separation • Purification • Sterilization • Buffer exchange • Concentration

  6. Industries

  7. Challenges • Membrane fouling • Pressure, flow, TMP, recirculation • System configuration • Interactions of parameters • Scale up loopholes Permeate Flow Operation Time

  8. Our Offerings • Wide range of membrane selections to meet diversified applications • Materials, SA, Pore size, Geometry, etc. • Systems for both R&D and productions • Pre-assembled Membrane, Bags, and Tubing packages to improve your efficiencies • Direct tech support from application experts

  9. Spectrum Hollow Fiber Modules • Broadest Range of MWCO’s (1kD through 0.65 µm) • Membrane Types = PS, mPES, ME, RC, PP • Small Scale = MicroKros (5 cm2) • Large Scale = KrosFlo Max module (22 m2) • Sterile, Non-Sterile

  10. Benefits of mPES Membranes Characteristics Benefits • Hydrophilic membrane • Low protein binding • & slow fouling • High selectivity • High permeability • Easier R & D • Stable operations • High performance • Cost effective

  11. KRIIi makes R&D Easier • Provides all necessary components for your study • Automated TMP control • Real time data collection and graphic analysis • Small footprint • Provide solid data for scale up • Ideal for R&D and low volume production

  12. Process data exports directly into MS Excel in real time Calculated feed flow rate , shear, TMP, etc. Customizable alarm setting for process safety Pressure control with non-invasive valves Real-time graphing (virtual recording) Make the most of your experiment Recorded data for analysis KF Comm Data Collection System

  13. MBT Assemblies Permeate Flow Meter Pressure Transmitter

  14. MBT Assemblies • Reduce your setup or preparation time • Reduce process variability • Reduce your logistics burden • Improve your efficiencies and productivity

  15. Designed for Scalability • Membrane module sizes • Customizable

  16. Designed for Scalability • Complete line of process systems • KF Comm Date Collection System generates solid data for scale up • Scale up guided by technical sound rationales KrosFlo Research IIi KrosFlo MiniKros Pilot KrosFlo LDF-55

  17. MBT Systems for different scales • Compatible with KFComm data collection systems. • Customizable and optimized system setup and configuration for different systems • KR2i – Bench Scale • KMP – Pilot Scale • LDF37 – Production • Khameleon Perfusion Systems

  18. SUMMARY • Wide selection of membranes including our unique offering of high performance mPES membrane. • KRIIi research TFF system make your R&D easier. • Single use MBT system improve your efficiency • Complete product line and common data collection software ensures smooth transfer for R&D to production. • Direct onsite technical service available • Competitive price

  19. Thank You多谢光临

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