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SPINTRONIC NANOSENSORS for MEDICINE Prof. Riccardo Bertacco Centro LNESS Politecnico di Milano

SPINTRONIC NANOSENSORS for MEDICINE Prof. Riccardo Bertacco Centro LNESS Politecnico di Milano Via Anzani 42, 22100 Como riccardo.bertacco@polimi.it. Spintronic biosensors for molecular recognition. 2. streptavidin. probe. biotin. target. Advantages. No background No bleaching

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SPINTRONIC NANOSENSORS for MEDICINE Prof. Riccardo Bertacco Centro LNESS Politecnico di Milano

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  1. SPINTRONIC NANOSENSORS for MEDICINE Prof. Riccardo Bertacco Centro LNESS Politecnico di Milano Via Anzani 42, 22100 Como riccardo.bertacco@polimi.it

  2. Spintronic biosensors for molecular recognition 2 streptavidin probe biotin target Advantages • No background • No bleaching • High stability • Molecule handling • High biological sensitivity • Tayloring the dinamic range • Lab on chip R R’ Disadvantages • Not label free • Impact of beads on the chemical affinity ?

  3. SpinNanoMed FP7: NMP-2008-1.1-1 Converging sciences and technologies (nano, bio, info and/or cognitive) SPINTRONIC NANOSORS for MEDICINE • Preventive medicine and diagnosis (in vitro diagnostic tests) • Specific application: Early detection of breast cancer via proteome profiling on the serum of patients Lab on chip approach for point of care applications.

  4. Insulating layer substrate Read out electronics (ASIC) System layout Biomedical validation DSP Data mining End user interface AD conversion Microfluidics SiO2 + polymer

  5. Electronics • An ASIC, to be placed around the sensor chip, must be designed and realized with these functionalities: • front end electronics for the signal read out • analogical signal processing (filtering, amplification, ...) • A second external circuit will make the analog to digital conversion and provide suitable signal to an external PC for data acquisition and analysis.

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