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Ch 9:T cell receptor

Ch 9:T cell receptor. Where we’re going. Structure of the TCR- alpha and beta chains ( αβ ) The γδ Tcells- know a bit about them The CD3 components and signal transduction-cover much, responsible for just a few concepts. Alloreactivity. Review of TCR’s.

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Ch 9:T cell receptor

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  1. Ch 9:T cell receptor

  2. Where we’re going • Structure of the TCR- alpha and beta chains (αβ) • The γδTcells- know a bit about them • The CD3 components and signal transduction-cover much, responsible for just a few concepts. • Alloreactivity

  3. Review of TCR’s • Th and Tc; Th respond to MHC II Ag presentation, help B and Tc cells. CD4 coreceptor • Tc respond to MHC I Ag presentation (endogenous), and kill virus-infected/cancerous cells. CD8

  4. Both alpha and beta are somewhat like the H chain Short tails- need CD3!

  5. γδTcells- something different LOW diversity Many w/ no CD4/CD8 Gut Phospholipid antigens

  6. Delta embedded in alpha!

  7. The delta’s are LOST! This happens first

  8. The joint is CD3- the others vary, but not as much. Not somatic hypermutation This is weird!!

  9. Short tails = needs help for signal transduction Help provided by CD3- a complex Opposites attract! Immunoreceptor tyrosine-based activation motif!

  10. T-cell receptor binding is weak; thus the need for accessories

  11. Alloreactivity • It’s what gets you in tissue rejection • Contradicts MHC restriction! • Large # of T cells react- 1-5%! • Lots of theories, but clearly there’s a somewhat non-specific binding that sets off the T cell.

  12. Things to know • Structure of the TCR- alpha and beta chains (αβ) • The γδTcells- know a bit about them • The CD3 components and signal transduction- ITAMS, B7-CD28, CD4,CD8 • Alloreactivity

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