Arpizol Tablets (Generic Aripiprazole Tablets)

1. Arpizol Tablets (Generic Aripiprazole Tablets) © Clearsky Pharmacy ( www.clearskypharmacy.biz )

2. Arpizol Tablets (Generic Aripiprazole Tablets) Arpizol (Generic Aripiprazole Tablets) is indicated for the treatment of schizophrenia in adults and in adolescents aged 15 years and older. Arpizol is indicated for the treatment of moderate to severe manic episodes in Bipolar I Disorder and for the prevention of a new manic episode in adults who experienced predominantly manic episodes and whose manic episodes responded to Aripiprazole treatment. Arpizol is indicated for the treatment up to 12 weeks of moderate to severe manic episodes in Bipolar I Disorder in adolescents aged 13 years and older. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

3. Arpizol Tablets (Generic Aripiprazole Tablets) Active Ingredient The active ingredient present in Arpizol tablets is Aripiprazole. Each tablet of Arpizol contains either 5 mg, 10 mg, 15 mg, 20 mg or 30 mg of Aripiprazole. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

4. Arpizol Tablets (Generic Aripiprazole Tablets) Chemical Structure The structure of Aripiprazole is given below: © Clearsky Pharmacy ( www.clearskypharmacy.biz )

5. Arpizol Tablets (Generic Aripiprazole Tablets) Arpizol Tablets are manufactured by Sun Pharmaceutical Industries Limited, India in the strengths of 5 mg, 10 mg, 15 mg, 20 mg and 30 mg. ( Website: https://sunpharma.com/ ) URL: https://www.clearskypharmacy.biz/generic-abilify-arpizol-by-sun-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

6. Arpizol Tablets (Generic Aripiprazole Tablets) Aripiprazole Tablets – Brand Names Aripiprazole tablets are available under various drug trade names that include Abilify, Arpizol, Asprito, Apicord, Aridus, Aripiprex, Aria, Arilan, Arip MT, Arzu, Aripra, Aripat -MD, Biliff and many others. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

7. Arpizol Tablets (Generic Aripiprazole Tablets) Uses of Arpizol Tablets Arpizol (Generic Aripiprazole Tablets) is used alone or together with other medicines to treat mental conditions such as bipolar I disorder (manic-depressive illness), major depressive disorder, and schizophrenia. It is also used in children to treat irritability associated with autistic disorder and Tourette syndrome. Aripiprazole works in the brain to change how certain chemicals affect patients. It is an antipsychotic agent. URL: https://www.clearskypharmacy.biz/generic-abilify-arpizol-by-sun-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

8. Arpizol Tablets (Generic Aripiprazole Tablets) Arpizol Tablets Dosage The dosage of Arpizol tablets (Generic Aripiprazole Tablets) is given below: Schizophrenia In Adults: The recommended dosage for the treatment of Schizophrenia in adults is 10 mg to 15 mg/day with an initial dosage of 10 mg to 15 mg/day and a maximum of 30 mg/day. Schizophrenia In Adolescents: The recommended target dose of Aripiprazole is 10 mg/day. Aripiprazole was studied in adolescent patients 13 to 17 years of age with schizophrenia at daily doses of 10 mg and 30 mg. The starting daily dose of the tablet formulation in these patients was 2 mg, which was titrated to 5 mg after 2 days and to the target dose of 10 mg after 2 additional days. Subsequent dose increases should be administered in 5 mg increments. URL: https://www.clearskypharmacy.biz/generic-abilify-arpizol-by-sun-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

9. Arpizol Tablets (Generic Aripiprazole Tablets) Arpizol Tablets Dosage The dosage of Arpizol tablets (Generic Aripiprazole Tablets) is given below: Bipolar Mania In Adults: monotherapy the initial dosage is 15 mg/day, the recommended dosage is 15 mg/day and the maximum dosage 30 mg/day. In case Generic Abilify tablets are used as an adjunct to lithium or valproate the initial dose is 10 mg to 15 mg/day, the recommended dose is 15 mg/day with the maximum dose being 30 mg/day Major Depressive Disorder In Adults: The recommended dosage of Aripiprazole Tablets for the treatment of major depressive disorder in adults as an adjunct to antidepressants is 5 mg to 10 mg/day with the starting dose as 2 mg to 5 mg/day and the maximum dose being 15 mg/day. URL: https://www.clearskypharmacy.biz/generic-abilify-arpizol-by-sun-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

10. Arpizol Tablets (Generic Aripiprazole Tablets) Contraindications Arpizol tablets are contraindicated in patients with a hypersensitivity (allergy) to Aripiprazole or any of the other ingredients of this medicine. URL: https://www.clearskypharmacy.biz/generic-abilify-arpizol-by-sun-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

11. Arpizol Tablets (Generic Aripiprazole Tablets) Storage Instructions Arpizol Tablets (Generic Aripiprazole Tablets) have to be stored at controlled room temperature i.e. from 20°C to 25°C (68°F to 77°F) with excursions permitted between 15° to 30°C (59° to 86°F). Keep this as well as all other medicines away from children and pets. URL: https://www.clearskypharmacy.biz/generic-abilify-arpizol-by-sun-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

12. Arpizol Tablets (Generic Aripiprazole Tablets) Warnings Cerebrovascular Adverse Reactions in Elderly Patients with Dementia- Related Psychosis: Increased incidence of cerebrovascular adverse reactions (e.g., stroke, transient ischemic attack, including fatalities. Neuroleptic Malignant Syndrome: Manage with immediate discontinuation and close monitoring. Tardive Dyskinesia: Discontinue if clinically appropriate. Metabolic Changes: Atypical antipsychotic drugs have been associated with metabolic changes that include hyperglycemia/ diabetes mellitus, dyslipidemia, and body weight gain. Hyperglycemia/Diabetes Mellitus: Monitor glucose regularly in patients with and at risk for diabetes. Dyslipidemia: Undesirable alterations in lipid levels have been observed in patients treated with atypical antipsychotics. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

13. Arpizol Tablets (Generic Aripiprazole Tablets) Warnings Weight Gain: Weight gain has been observed with atypical antipsychotic use. Monitor weight. Pathological Gambling and Other Compulsive Behaviors: Consider dose reduction or discontinuation. Orthostatic Hypotension: Monitor heart rate and blood pressure and warn patients with known cardiovascular or cerebrovascular disease, and risk of dehydration or syncope. Leukopenia, Neutropenia, and Agranulocytosis: have been reported with antipsychotics including Arpizol (Generic Aripiprazole Tablets). Patients with a history of a clinically significant low white blood cell count (WBC) or a drug- induced leukopenia/neutropenia should have their complete blood count (CBC) monitored frequently during the first few months of therapy and discontinuation of Arpizol tablets should be considered at the first sign of a clinically significant decline in WBC in the absence of other causative factors. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

14. Arpizol Tablets (Generic Aripiprazole Tablets) Warnings Seizures/Convulsions: Use cautiously in patients with a history of seizures or with conditions that lower the seizure threshold. Potential for Cognitive and Motor Impairment: Use caution when operating machinery. Suicide: The possibility of a suicide attempt is inherent in schizophrenia and bipolar disorder. Closely supervise high-risk patients. URL: https://www.clearskypharmacy.biz/generic-abilify-arpizol-by-sun-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

15. Arpizol Tablets (Generic Aripiprazole Tablets) Driving And Using Machines Dizziness and vision problems may occur during treatment with Arpizol (Aripiprazole tablets). This should be considered in cases where full alertness is required, e.g. when driving a car or handling machines. URL: https://www.clearskypharmacy.biz/generic-abilify-arpizol-by-sun-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

16. Arpizol Tablets (Generic Aripiprazole Tablets) Side Effects Commonly observed Aripiprazole (Arpizol tablets) side effects with an incidence rate of 5% and at least twice that for placebo) were: Adult patients with schizophrenia: akathisia Pediatric patients (13 to 17 years) with schizophrenia: extrapyramidal disorder, somnolence, and tremor Adult patients (monotherapy) with bipolar mania: akathisia, sedation, restlessness, tremor, and extrapyramidal disorder Adult patients (adjunctive therapy with lithium or valproate) with bipolar mania: akathisia, insomnia, and extrapyramidal disorder Pediatric patients (10 to 17 years) with bipolar mania: somnolence, extrapyramidal disorder, fatigue, nausea, akathisia, blurred vision, salivary hypersecretion, and dizziness. URL: https://www.clearskypharmacy.biz/generic-abilify-arpizol-by-sun-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

17. Arpizol Tablets (Generic Aripiprazole Tablets) Side Effects Commonly observed Aripiprazole (Arpizol tablets) side effects with an incidence rate of 5% and at least twice that for placebo) were: Adult patients with major depressive disorder (adjunctive treatment to antidepressant therapy): akathisia, restlessness, insomnia, constipation, fatigue, and blurred vision Pediatric patients (6 to 17 years) with autistic disorder: sedation, fatigue, vomiting, somnolence, tremor, pyrexia, drooling, decreased appetite, salivary hypersecretion, extrapyramidal disorder, and lethargy Pediatric patients (6 to 18 years) with Tourette’s disorder: sedation, somnolence, nausea, headache, nasopharyngitis, fatigue, increased appetite Adult patients with agitation associated with schizophrenia or bipolar mania: nausea. URL: https://www.clearskypharmacy.biz/generic-abilify-arpizol-by-sun-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

18. Arpizol Tablets (Generic Aripiprazole Tablets) Overdose Common adverse reactions (reported in at least 5% of all overdose cases) reported with oral Aripiprazole (Arpizol tablets) overdosage (alone or in combination with other substances) include vomiting, somnolence, and tremor. Other clinically important signs and symptoms observed in one or more patients with Aripiprazole tablets overdoses (alone or with other substances) include acidosis, aggression, aspartate aminotransferase increased, atrial fibrillation, bradycardia, coma, confusional state, convulsion, blood creatine phosphokinase increased, depressed level of consciousness, hypertension, hypokalemia, hypotension, lethargy, loss of consciousness, QRS complex prolonged, QT prolonged, pneumonia aspiration, respiratory arrest, status epilepticus, and tachycardia. URL: https://www.clearskypharmacy.biz/generic-abilify-arpizol-by-sun-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

19. Arpizol Tablets (Generic Aripiprazole Tablets) Overdose No specific information is available on the treatment of overdose with Aripiprazole (Arpizol tablets). An electrocardiogram should be obtained in case of overdosage and if QT interval prolongation is present, cardiac monitoring should be instituted. Otherwise, management of overdose should concentrate on supportive therapy, maintaining an adequate airway, oxygenation and ventilation, and management of symptoms. Close medical supervision and monitoring should continue until the patient recovers. Charcoal: In the event of an overdose of Aripiprazole, an early charcoal administration may be useful in partially preventing the absorption of Aripiprazole. Administration of 50 g of activated charcoal, one hour after a single 15 mg oral dose of Aripiprazole, decreased the mean AUC and Cmax of Aripiprazole by 50%. Hemodialysis: Although there is no information on the effect of hemodialysis in treating an overdose with Aripiprazole, hemodialysis is unlikely to be useful in overdose management since Aripiprazole is highly bound to plasma proteins. URL: https://www.clearskypharmacy.biz/generic-abilify-arpizol-by-sun-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

20. Arpizol Tablets (Generic Aripiprazole Tablets) Arpizol Tablets During Pregnancy Aripiprazole (Arpizol tablets) is classified by the US FDA as Pregnancy Category C. There have been several reports of agitation, hypertonia, hypotonia, tremor, somnolence, respiratory distress and feeding disorder in neonates exposed to antipsychotic drugs during the third trimester of pregnancy. These complications have varied in severity; while in some cases symptoms have been self-limited, in other cases neonates have required intensive care unit support and prolonged hospitalization. Consider the risk of untreated depression when discontinuing or changing treatment with antidepressant medication during pregnancy and postpartum. URL: https://www.clearskypharmacy.biz/generic-abilify-arpizol-by-sun-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

21. Arpizol Tablets (Generic Aripiprazole Tablets) For more details on Arpizol tablets click here Arpizol Tablets (Generic Aripiprazole Tablets) by Sun Pharmaceutical Industries Limited, India. URL: https://www.clearskypharmacy.biz/generic-abilify-arpizol-by-sun-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )