Nalsign Tablets (Generic Naltrexone Hydrochloride Tablets)

1. Nalsign Tablets (Generic Naltrexone Hydrochloride Tablets) © Clearsky Pharmacy ( www.clearskypharmacy.biz )

2. Nalsign Tablets (Generic Naltrexone Hydrochloride Tablets) Nalsign (Generic Naltrexone Hydrochloride Tablets) is used for the treatment of alcohol dependence in patients who are able to abstain from alcohol in an outpatient setting before starting treatment with Nalsign tablets. Patients should not be actively drinking at the time of starting Nalsign administration. Nalsign is also used for the prevention of relapse to opioid dependence, following opioid detoxification. Generic Naltrexone Hydrochloride Tablets must be part of a comprehensive management program that includes psychosocial support. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

3. Nalsign Tablets (Generic Naltrexone Hydrochloride Tablets) Active Ingredient The active ingredient contained in Nalsign tablets is Naltrexone Hydrochloride. Each film-coated Nalsign tablet contains 50 mg of Naltrexone Hydrochloride. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

4. Nalsign Tablets (Generic Naltrexone Hydrochloride Tablets) Chemical Structure The structure of Naltrexone Hydrochloride is given below: © Clearsky Pharmacy ( www.clearskypharmacy.biz )

5. Nalsign Tablets (Generic Naltrexone Hydrochloride Tablets) Nalsign Tablets are manufactured by Hab Pharmaceuticals and Research Limited, India (Signature) in the strength of 50 mg. ( Website: https://www.habpharma.in https://www.habpharma.in ) URL: URL: https://www.clearskypharmacy.biz/naltrexone-tablets-nodict-by-sun-pharma.html https://www.clearskypharmacy.biz/naltrexone-tablets-nodict-by-sun-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

6. Nalsign Tablets (Generic Naltrexone Hydrochloride Tablets) Naltrexone Hydrochloride Tablets – Brand Names Naltrexone Hydrochloride tablets are available under various drug brand names such as Revia, Nodict, Nalsign, Nalcon, Naltima, Addtrex, Gigadict, Naltox, Naltrex, Naltreat, Vivitrol, and Depade. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

7. Nalsign Tablets (Generic Naltrexone Hydrochloride Tablets) Uses of Nalsign Tablets Nalsign (Generic Naltrexone Hydrochloride Tablets) is used to help narcotic dependents who have stopped taking narcotics to stay drug-free. It is also used to help alcoholics stay alcohol-free. The medicine is not a cure for addiction. It is used as part of an overall program that may include counseling, attending support group meetings, and other treatment recommended by your doctor. Naltrexone is not a narcotic. It works by blocking the effects of narcotics, especially the "high'' feeling that makes you want to use them. It also may block the "high'' feeling that may make you want to use alcohol. URL: URL: https://www.clearskypharmacy.biz/naltrexone-tablets-nodict-by-sun-pharma.html https://www.clearskypharmacy.biz/naltrexone-tablets-nodict-by-sun-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

8. Nalsign Tablets (Generic Naltrexone Hydrochloride Tablets) Uses of Nalsign Tablets This medication may be given as part of a program where a health care professional will watch you take the medication. In this case, your doctor may order a higher dose (100-150 milligrams) to be taken every 2-3 days to make it easier to schedule clinic visits. Naltrexone may be taken with food or antacids if stomach upset occurs. URL: URL: https://www.clearskypharmacy.biz/naltrexone-tablets-nodict-by-sun-pharma.html https://www.clearskypharmacy.biz/naltrexone-tablets-nodict-by-sun-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

9. Nalsign Tablets (Generic Naltrexone Hydrochloride Tablets) Nalsign Tablets Dosage Nalsign tablets (Naltrexone Hydrochloride Tablets) is The dosage of Nalsign tablets given below: Treatment of Alcoholism: Treatment of Alcoholism: A dose of 50 mg once daily is recommended for most patients. During controlled studies which proved the efficacy of Naltrexone tablets as an effective adjunctive treatment of alcoholism a dose regimen of Naltrexone 50 mg once daily for up to 12 weeks was used. Treatment of Opioid Dependence: Treatment of Opioid Dependence: Treatment should begin with an initial dose of 25 mg of Naltrexone. If no withdrawal signs occur, the patient may be started on 50 mg a day thereafter. URL: URL: https://www.clearskypharmacy.biz/naltrexone-tablets-nodict-by-sun-pharma.html https://www.clearskypharmacy.biz/naltrexone-tablets-nodict-by-sun-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

10. Nalsign Tablets (Generic Naltrexone Hydrochloride Tablets) Contraindications Nalsign is contraindicated in patients with a hypersensitivity to Naltrexone, Polylactide-Co-Glycolide (PLG), Carboxymethylcellulose, or any other component of this medication. This medicine is also contraindicated in Patients receiving opioid analgesics, Patients with current physiologic opioid dependence, Patients in acute opioid withdrawal and any individual who has failed the Naloxone challenge test or has a positive urine screen for opioids. URL: URL: https://www.clearskypharmacy.biz/naltrexone-tablets-nodict-by-sun-pharma.html https://www.clearskypharmacy.biz/naltrexone-tablets-nodict-by-sun-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

11. Nalsign Tablets (Generic Naltrexone Hydrochloride Tablets) Storage Instructions Nalsign Tablets (Generic Naltrexone Hydrochloride Tablets) have to be stored at controlled room temperature i.e. from 20°C to 25°C (68°F to 77°F) with excursions permitted between 15° to 30°C (59° to 86°F). Keep this as well as all other medicines away from children and pets. URL: URL: https://www.clearskypharmacy.biz/naltrexone-tablets-nodict-by-sun-pharma.html https://www.clearskypharmacy.biz/naltrexone-tablets-nodict-by-sun-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

12. Nalsign Tablets (Generic Naltrexone Hydrochloride Tablets) Warnings Vulnerability to Opioid Overdose: Patients who have been treated with Nodict may respond to lower doses of opioids than previously used, just as they would shortly after completing detoxification. This could result in potentially life-threatening opioid intoxication (respiratory compromise or arrest, circulatory collapse, etc.) if the patient uses previously tolerated doses of opioids. Precipitated Opioid Withdrawal: The symptoms of spontaneous opioid withdrawal are uncomfortable, but they are not generally seen to be severe or necessitate hospitalization. However, when withdrawal is precipitated suddenly by the administration of an opioid antagonist to an opioid-dependent patient, the resulting withdrawal syndrome can be severe enough to require hospitalization. URL: URL: https://www.clearskypharmacy.biz/naltrexone-tablets-nodict-by-sun-pharma.html https://www.clearskypharmacy.biz/naltrexone-tablets-nodict-by-sun-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

13. Nalsign Tablets (Generic Naltrexone Hydrochloride Tablets) Warnings Hepatotoxicity: Cases of hepatitis and clinically significant liver dysfunction were noticed in association with Naltrexone Hydrochloride (Nalsign Tablets) exposure during the clinical development program and in the postmarketing period. Transient, asymptomatic hepatic transaminase elevations were also seen in the clinical trials and postmarketing period. Depression and Suicidality: Depression, suicide, attempted suicide and suicidal ideation have been reported in the postmarketing experience with Naltrexone Hydrochloride tablets used in the treatment of opioid dependence. URL: URL: https://www.clearskypharmacy.biz/naltrexone-tablets-nodict-by-sun-pharma.html https://www.clearskypharmacy.biz/naltrexone-tablets-nodict-by-sun-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

14. Nalsign Tablets (Generic Naltrexone Hydrochloride Tablets) Driving And Using Machines Naltrexone may impair the mental and/or physical abilities required for performance of potentially hazardous tasks such as driving a car or operating machinery. URL: URL: https://www.clearskypharmacy.biz/naltrexone-tablets-nodict-by-sun-pharma.html https://www.clearskypharmacy.biz/naltrexone-tablets-nodict-by-sun-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

15. Nalsign Tablets (Generic Naltrexone Hydrochloride Tablets) Side Effects The side effects seen most frequently in association with Naltrexone therapy for alcohol dependence occurring in 5% or more of the patients and at least twice as frequently with Naltrexone than placebo) include nausea, vomiting, muscle cramps, dizziness or syncope, somnolence or sedation, anorexia, decreased appetite or other appetite disorders. The side effects observed most commonly in association with Naltrexone therapy for in opioid-dependent patients (i.e., those occurring in at least 2% or more of patients treated with Naltrexone and at least twice as frequently with Naltrexone than placebo) were hepatic enzyme abnormalities, nasopharyngitis, insomnia, and toothache. URL: URL: https://www.clearskypharmacy.biz/naltrexone-tablets-nodict-by-sun-pharma.html https://www.clearskypharmacy.biz/naltrexone-tablets-nodict-by-sun-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

16. Nalsign Tablets (Generic Naltrexone Hydrochloride Tablets) Overdose During one study, patients who received 800 mg of Naltrexone tablets daily for up to one week showed no evidence of toxicity. High doses of Naltrexone Hydrochloride tablets, usually equal to or in excess of 1,000 mg/kg produced salivation, depression/reduced activity, tremors, and convulsions. Mortalities in animals due to high- dose Naltrexone administration usually were due to clonic-tonic convulsions and/or respiratory failure. URL: URL: https://www.clearskypharmacy.biz/naltrexone-tablets-nodict-by-sun-pharma.html https://www.clearskypharmacy.biz/naltrexone-tablets-nodict-by-sun-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

17. Nalsign Tablets (Generic Naltrexone Hydrochloride Tablets) Nalsign Tablets During Pregnancy Naltrexone Hydrochloride (Nalsign Tablets) has been classified by the US FDA as Pregnancy Category C. Naltrexone has been shown to increase the incidence of early fetal loss when given to rats at doses of 30 mg/kg/day or more(180 mg/m2/day; 5 times the recommended therapeutic dose, based on body surface area). There are no adequate and well-controlled studies in pregnant women. Nalsign tablets should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. URL: URL: https://www.clearskypharmacy.biz/naltrexone-tablets-nodict-by-sun-pharma.html https://www.clearskypharmacy.biz/naltrexone-tablets-nodict-by-sun-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

18. Nalsign Tablets (Generic Naltrexone Hydrochloride Tablets) For more details on Nalsign Tablets click here Nalsign Tablets click here Nalsign Tablets (Naltrexone Hydrochloride Tablets) by HAB Pharmaceuticals and Research Limited, India (Signature). URL: URL: https://www.clearskypharmacy.biz/naltrexone-tablets-nodict-by-sun-pharma.html https://www.clearskypharmacy.biz/naltrexone-tablets-nodict-by-sun-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )