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Nordic Naturals Education Department presents… Fish Oil and Fat Loss

Nordic Naturals Education Department presents… Fish Oil and Fat Loss. Presented by: Dr. Christopher Mohr, PhD, RD. Overview. Review statistics on overweight and obesity in America Discuss co-morbidities and mortality associated with overweight and obesity

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Nordic Naturals Education Department presents… Fish Oil and Fat Loss

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  1. Nordic Naturals Education Department presents… Fish Oil and Fat Loss Presented by: Dr. Christopher Mohr, PhD, RD

  2. Overview • Review statistics on overweight and obesity in America • Discuss co-morbidities and mortality associated with overweight and obesity • Review the role of omega-3 fats in different disease states associated with obesity • Discuss the emerging role of omega-3 fats in weight loss

  3. “Today, at the start of the new year, millions of Americans will resolve to lose weight, but by tomorrow or next week, or maybe next month, most of them will give up trying. Few will have lost weight, and even fewer will sustain that weight loss.” Editors, NEJM,January1, 1998

  4. Prevalence of Overweight and Obesity Among U.S. Adults BMI≥25 BMI≥30 Percentage NHANES Surveys At Different Time Points JAMA. 2006 Apr 5;295(13):1549-55.

  5. Obesity Trends* Among U.S. Adults – BRFSS, 1985 (*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person) No Data <10% 10–14%

  6. Obesity Trends* Among U.S. Adults – BRFSS, 1990 (*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person) No Data <10% 10–14%

  7. Obesity Trends* Among U.S. Adults – BRFSS, 1995 (*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person) No Data <10% 10–14% 15–19%

  8. Obesity Trends* Among U.S. Adults – BRFSS, 2000 (*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person) No Data <10% 10–14% 15–19% ≥20%

  9. Obesity Trends* Among U.S. Adults – BRFSS, 2005 (*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person) No Data <10% 10%–14 15%–19% 20%–24% 25%–29% No Data <10% 10%–14% 15%–19% 20%–24% 25%–29% ≥30%

  10. Obesity Trends* Among U.S. Adults – BRFSS, 2006 (*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person) No Data <10% 10%–14% 15%–19% 20%–24% 25%–29% ≥30%

  11. Obesity Trends* Among U.S. Adults – CDC, 2007 (*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person) No Data <10% 10%–14% 15%–19% 20%–24% 25%–29% ≥30%

  12. Obesity Trends* Among U.S. Adults – CDC, 2008 (*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person) New York: 24.4% No Data <10% 10%–14% 15%–19% 20%–24% 25%–29% ≥30%

  13. Consequences of Obesity Hypertension Sleep Apnea Cancer Obesity Osteoarthritis Cardiovascular Disease Insulin Resistance/ Hyperinsulinemia Stroke Social Disability Hyperlipidemia Diabetes Mellitus Cardiovascular Disease Diabetic Complications

  14. Putting the Focus on Fat SATURATED (~7% of total intake) (no double bonds, solid) * animal fats * tropical oils UNSATURATED (1 or more double bonds, liquid) Processing PUFA (poly-unsaturated) (mono-unsaturated) Trans Fats MUFA partially hydrogenated * olive * canola * nuts * avocado Omega-3Omega-6 * fish/fish oil * corn * Flaxseed * safflower * Walnuts * sunflower

  15. Putting the Focus on Fat • Intake of omega-6 fats has increased and omega-3 fats has decreased • Current ratio of omega-6:omega-3 is as high as around 25:1 • This promotes the pathogenesis of disease through increased inflammation • Humans evolved on a diet with a ratio of omega-6:omega-3 closer to 1 1 Biomed Pharmacother 2002;56(8):365–79

  16. Omega-3 for Fat Loss? • Recent research suggests omega-3 fats may play a role with fat loss in humans and animal models • Further studies need to be conducted to ascertain the exact mechanism(s) • Increase in fat oxidation? • Improved fat mobilization? • Decrease in heart rate variability and resting heart rate? International Journal of Obesity 1997;(21) 637–643 International Journal of Obesity 2007;1–7 Circulation 2003;108(7):820–5

  17. Combining Fish Oil Supplements with Regular Aerobic Exercise Improves Body Composition and Cardiovascular Disease Risk Factors American Journal of Clinical Nutrition 2007;(85)1267–1274

  18. Objective • Examine the individual and combined effects of omega-3 fatty acid supplements and regular exercise on body composition and cardiovascular health • Subjects: • Overweight (BMI ≥ 25 kg/m2) • 24 men, 41 women • ≥ 1 cardiovascular risk factors: hypertension, elevated triglycerides (TG), and/or elevated cholesterol • ~50 years of age • Physically Inactive

  19. Methods • 12 week study • Subjects randomly assigned to 1 of 4 groups • Balanced for sex, BMI, triglycerides • Two groups took 6 g DHA-rich fish oil per day • Provided 1560 mg DHA and 360 mg EPA • Two groups took 6 g placebo (sunflower oil) • One group assigned to each oil group & participated in regular physical activity • Run or walk 3 times a week for 45 minutes at 75% of age-predicted heart rate max • All subjects completed 3 day food records

  20. Plasma Lipids • Fish oil groups (FO) reduced TG significantly vs. the sunflower oil (SO) groups (~14% vs. ~5%) • FO groups increased HDL significantly vs. SO groups (~10% vs. ~3%) • FO groups caused a significant improvement in flow mediated dilation (FMD) compared to SO groups • These changes were not independently related to exercise when controlled for in the analyses

  21. Body Fat Changes Over Time FO = Fish Oil; FOEx = Fish oil with exercise P < 0.05 SO = sunflower oil; SOEx = sunflower oil with exercise

  22. DEXA Assessed Changes in Fat and Lean Mass Fat Mass Fat Free Mass FO = Fish Oil; FOEx = Fish oil with exercise P < 0.05 SO = sunflower oil; SOEx = sunflower oil with exercise

  23. Body Mass Index Change Over Time FO = Fish Oil; FOEx = Fish oil with exercise P < 0.05 SO = sunflower oil; SOEx = sunflower oil with exercise

  24. Summary • This study confirms regular supplementation with a DHA-rich fish oil can improve multiple cardiovascular risk factors (e.g., TG, HDL, FMD) • This is the first study to date to control for exercise when combined with omega-3 supplementation for body composition

  25. Take Home Messages • Fish oil supplements and regular exercise both reduce body fat and improved cardiovascular and metabolic health • Increasing intake of omega-3 fats could be a useful adjunct to exercise programs aimed at improving body composition and decreasing cardiovascular disease risk

  26. Monday Morning Messages • It is well established that omega-3 fats modulate cardiovascular risk factors. • The American Heart Association Recommends: • Eating fatty fish at least twice a week (up to 12 oz) • If heart disease is present, consume 1–2 g (1000–2000 mg) of EPA and DHA daily from fish or supplements after talking with a medical professional • Supplement with 2–4 g/day of EPA and DHA if you have elevated triglycerides (TG) under a physician’s care http://www.americanheart.org

  27. Data on Fat Loss? Data on omega-3 fats and fat loss continues to emerge • While most studies have been conducted in animal models, more are being done in humans, and each show positive results • Few studies have explored the specific mechanisms, although animal models provide a solid basis of how they exert their effect

  28. Why Nordic Naturals?

  29. Third-Party Test Results For Purity and Freshness Nordic Naturals Retail Line Dioxins4& Furans Dioxin-like PCBs5Non- & Mono-ortho Heavy Metals3 Peroxide Value1 Totox2 Total PCBs6 Product Arctic Cod Liver Oil <0.1 ppm 0.6 mEq/kg 6.3 mEq/kg <2.0 ppt <1.0 ppt <0.09 ppm Children’s DHA 0.6 mEq/kg 6.3 mEq/kg <0.1 ppm <2.0 ppt <1.0 ppt <0.09 ppm DHA 0.6 mEq/kg 11.2 mEq/kg <0.1 ppm <2.0 ppt <1.0 ppt <0.09 ppm EPA 0.5 mEq/kg 6.0 mEq/kg <0.1 ppm <2.0 ppt <1.0 ppt <0.09 ppm Omega-3 0.9 mEq/kg 12.0 mEq/kg <0.1 ppm <2.0 ppt <1.0 ppt <0.09 ppm Ultimate Omega 0.4 mEq/kg 4.8 mEq/kg <0.1 ppm <2.0 ppt <1.0 ppt <0.09 ppm Complete Omega-3.6.9 0.6 mEq/kg <0.1 ppm <2.0 ppt <1.0 ppt 11.3 mEq/kg <0.09 ppm Omega Woman 0.5 mEq/kg 12.8 mEq/kg <0.1 ppm <2.0 ppt <1.0 ppt <0.09 ppm 1 Peroxide—CRN & GOED limit: 5.0 mEq/kg 2 Totox (Total Oxidation)—CRN (Council for Responsible Nutrition) limit: 26 mEq/kg 3 Heavy Metals—Not detectable down to 0.1 ppm (particles per million). CRN & GOED limit: 0.1 ppm 4 Dioxins & Furans—Not detectable down to 2.0 ppt (particles per trillion). CRN & GOED limit: 2.0 ppt 5 Dioxin-like PCBs—Not detectable down to 1.0 ppt (particles per trillion). CRN & GOED limit: 3.0 ppt6 PCBs—Not detectable down to 0.09 ppm (particles per million). CRN & GOED & Prop 65 limit: 0.09 ppm All tests are performed by Third-Party Laboratories in the United States, Canada, and Norway.

  30. Nordic Naturals – For the Record • Purity: patented purification process ensures freedom from all environmental toxins • Freshness: oxygen-free processing • Pleasant Taste:proprietary deodorization ensures no fishy taste or aftertaste • Natural Triglyceride Form:ensures optimal absorption • Independently Tested: surpasses all international standards • Sustainably Harvested:protects the health of the oceans • Heavily Researched: Over 30 studies, 10 already published in peer reviewed journals

  31. Omega-3 Products The easy way to get your Omega-3s every day. Supports: • Cardiovascular health and neurological function* • Healthy Omega-3 (EPA and DHA) nutrient levels • Mind and mood enhancement* • Stress management*

  32. Conclusions • Omega-3 fats are essential. • Most American’s fatty acid intake is out of balance, with too many inflammatory omega-6s and too few anti-inflammatory omega-3s. • Supportive data continues to mound for the efficacy of omega-3 fats, including high quality, pure fish oils as part of a sound nutrition plan. • If data continue to pan out showing enhanced fat loss as well, it’s just one more of the virtually unlimited benefits. • Nordic Naturals products support a healthy body and weight.

  33. Dr. Christopher Mohr, PhD, RD Mohr Results chris@MohrResults.com Thank You! Disclaimer: This information is provided by Nordic Naturals, Inc. for educational purposes only. Current and peer-reviewed research is cited.It is not intended as medical advice of any kind.The educational information in this document is not intended to diagnose, treat, or cure any disease, nor has this document been reviewed or approved by the FDA.

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