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Lack of MIF and Testosterone

Lack of MIF and Testosterone. MALE pseudohermaphrodite. Female Pseudohermaphrodite arises from. Excess Androgen Exposure Usu d/t 21-Hydroxylase Deficiency. 23 y.o Female complains of amenorrhea. During PE, it is noted that she has scant pubic hair. Androgen Insensitivity Disorder

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Lack of MIF and Testosterone

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  1. Lack of MIF and Testosterone • MALE pseudohermaphrodite

  2. Female Pseudohermaphrodite arises from • Excess Androgen Exposure • Usu d/t 21-Hydroxylase Deficiency

  3. 23 y.o Female complains of amenorrhea. During PE, it is noted that she has scant pubic hair. • Androgen Insensitivity Disorder • XY Genotype • Female Phenotype • Vagina ends blindly • Nml puberty growth with scant pubic hair, no menses. • Caused by defective androgen receptor

  4. Female Breast Pathology

  5. Most common breast disorder • FIBROCYSTIC DISEASE

  6. 27 y.o. Female presents with breast mass • Fibrocystic Disease • Most common cause of palpable breast mass in women 25-50 y.o

  7. 19 y.o Female presents with breast mass that feels firm, rubbery, but painless. Most likely cause: • Fibroadenoma • Most common cause of breast tumor in pts < 25 y.o

  8. Benign tumor of the lactiferous ducts • Intraductal Papilloma

  9. Benign but may present with serous or bloody discharge from the nipple • Adenoma of the nipple • Intraductal papilloma

  10. Large bulky mass with ulceration of underlying skin; Characteristic cystic spaces. Phyllodes Tumor

  11. Most Common Carcinoma of the Breast • Invasive Intraductal Carcinoma

  12. Bloody discharge from nipple; “Indian File” Lobular Carcinoma

  13. Breast Mass with Dense Fibrous Stroma Invasive Ductal Carcinoma

  14. Breast Mass withScant stroma • Medullary Carcinoma

  15. Breast Mass withGelatinous Consistency • Mucinous Carcinoma

  16. Breast Mass: Histo showslymphocytic infiltrate • Medullary Carcinoma

  17. Breast Mass:Soft, Fleshy Consistency • Medullary Carcinoma

  18. Female presents with red, hot, swollen skin over breast area • Inflammatory Carcinoma • Poor Prognosis

  19. Female presents with an eczematoid lesion of the nipple Paget Disease of the Breast

  20. Breast Mass:Cheese-like Consistency Comedocarcinoma

  21. Mammogram Negative Medullary Carcinoma

  22. Male Repro Pathology

  23. Inflammation of the GLANS PENIS BALANTITIS

  24. Opening on the DORSAL surface of the penis EPISPADIAS

  25. Occurs in older age group; Subcutaneous fibrosis of the dorsum of the penis PYERONIE DISEASE

  26. Gonorrhea most often manifest in males as: Acute purulent urethritis

  27. Lymphomagranuloma venereum:etiology Chlamydia trachomatis • vesicular ulcerating lesions • Inclusion bodies in epithelium • Suppuration • Scaring • Asymptomatic, localized, progressive, or elephatiasis

  28. 25 y.o sexually active Male presents with urethritis. No bacteria is demonstrated in the purulent urethral discharge. Chlamydial infxn – is sexually transmitted.

  29. ELEMENTARY BODIES are associated with? CHLAMYDIA - Affecting columnar or metaplastic cell more than squamous cells

  30. Hard, nontender, ulcerated Chancre Syphilis

  31. How do you culture Nesseria? Thayer-Martin Medium

  32. 25 y.o. Male presents with a shallow ulcer on his penis and also swollen draining nodes. CHANCROID

  33. Necrotic, tender, soft chancre CHANCHROID Haemophilus ducreyi

  34. Increased incidence of infxn of Haemophilius ducreyi in what countries? Orient West Indies Africa

  35. Donovan Bodies in Macrophages Granuloma inguinale Calymmatobacterium granulomatis • Creeping genital ulcers – disabling and deforming

  36. Suspected Genital Herpes:??? Test Tzanck Test: Multinucleated epithelial cells with inclusions

  37. Bowenoid Papulosis:Age Group < 30 y.o.

  38. Bowen Disease: Age group > 35 years old

  39. Erythroplasia of Queyrat: Age group Median Incidence in the 5th decade

  40. Condyloma Acuminatum: HPV?? HPV 6, 11

  41. Carcinoma in Situ: HPV ?? HPV 16

  42. Squamous Cell Carcinoma:HPV??? HPV 16, 18, 31, 33

  43. LEUKOPLAKIA assoc with? Bowen Disease

  44. Which carcinoma in situ is assoc with incr risk of visceral CA? Bowen Disease

  45. Presents with papular shaft lesions that have features of malignancy BUT limited to epithelial cells. BOWENOID Papulosis • Tend to regress

  46. Primary causes of Testicular Atrophy • Klinefelter Syndrome • Testicular Feminization (androgen insensitivity)

  47. Secondary causes of Testicular Atrophy • Hypogonadotrophic hypogonadisms • Artherosclerosis (old age) • Orchitis • Irradiation

  48. Cryptoorchidism:effects on spermatic tubules HYALINIZATION of spermatic tubules

  49. Tuberculosis may cause ??? in males EPIDYDIMITIS/scar

  50. Most common germ cell tumor SEMINOMA

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