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Project 3: Ultrasound Biomicroscopy, Technology Development

Project 3: Ultrasound Biomicroscopy, Technology Development. High frequency transducers and beamformers Guided injection Scanhead development Doppler and flow sensing High frequency nonlinear and contrast. Collaborating Groups. Commercial Partners.

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Project 3: Ultrasound Biomicroscopy, Technology Development

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  1. Project 3: Ultrasound Biomicroscopy,Technology Development • High frequency transducers and beamformers • Guided injection • Scanhead development • Doppler and flow sensing • High frequency nonlinear and contrast

  2. Collaborating Groups Commercial Partners MICe, Mt Sinai, Robarts, Queens, Univ of Virginia VisualSonics Commercial Collaborators AstraZeneca, Schering, Bracco, Imclone

  3. Transducers and Beamformers Marc Lucaks, Jian Hua Yin, Richard Garcia, Guofeng Pang, Kasia Harasiewicz, Jeremy Brown Doppler / Flow Andrew Needles, Victor Yang Nonlinear / Contrast Manu Cherin, Ross Williams, Olivier Couture, Kevin Cheung

  4. 5 MHz 300 microns 30 microns 50 MHz

  5. VisualSonicsVEVO 660 Mouse Scanner • B Mode (30 – 60) Hz • M Mode • Pulsed Doppler • EKV • 3D

  6. Realtime Scanhead

  7. Xenopus transverse section UBM - 30 fps 1 mm Yang, Needles et al U of Toronto

  8. Micro-injection into the Midbrain 30 frames/s, RMV Probe

  9. Chick embryo Day 3 Longitudinal Section Gharib/Brigande/Sahn/Thornberg labs: Cal Tech and Oregon Health and Sciences University

  10. Chick embryo Day 3 Longitudinal Section Gharib/Brigande/Sahn/Thornberg labs: Cal Tech and Oregon Health and Sciences University

  11. Array Development • Improve depth of field • Eliminate mechanical motion system • Improve system reliability

  12. Annular Array Development Jeremy Brown, Geoff Lockwood

  13. Theoretical and Experimental Radiation Patterns

  14. FPGA’s A/D’s

  15. High Frequency Linear Array Development 5 MHz 300 microns 30 microns 50 MHz

  16. Array Structure 75 microns SEM Images of Final Array Structure

  17. Vendor : Gennum Material: Alumina ceramic Metal Layer : Au-8,000 Angs. Indium Solder: Indalloy 1E Dimension=20 x 4 x 2 mils Inner Electrodes: Bond pad Pitch= 150 um Bond pad opening = 70 um 1 mm Solder Reflow Richard Garcia and George Brown College

  18. W:h = 0.43 35 Impedance of an Array Element

  19. Doppler / Flow Imaging • Cardiogenesis in animal models • Cardiovascular Hemodynamics • Micro-circulation • Tumour blood flow

  20. Imaging Tissue Motion: SAD map • Frame to frame clutter filtering with UBM at 15 fps R = Yang et al U of Toronto

  21. Chick embryo Day 3 Longitudinal Section Yang et al U of Toronto

  22. Doppler Colour Flow Imaging

  23. Ultrasound: Molecular Imaging Microbubble Contrast Agents Nanoparticle Contrast Agents • .5 – 5 microns • Gas filled • Inherently nonlinear • explodable • .1 – 1 microns • Liquid filled • Impedance enhanced signal

  24. Microbubble Contrast Agents 6 Million frames/s Chin, deJong et al, Erasmus U Rotterdam 30 frames/s

  25. 3 min 15 min 15 min (E.M.) Albumin Microbubble Phagocytosis • Denatured albumin in microbubble shell adheres to activated leukocytes attached to inflamed endothelium • Albumin microbubbles remain acoustically active after phagocytosis Courtesy of Dr. JR Lindner, Circulation 2000;102

  26. 30 min Inflammation Targeted Microbubbles 2 h Post-ischemia inflammation seen with leukocyte targeted lipid microbubbles whose shell contains phosphatidylserine MB-PS Infarct (TTC) Christiansen JP, et al., Circulation 2002

  27. Submicron Particles Intensity distribution of nanoparticles 500 nm • Liquid perflurocarbon, water, surfactant

  28. 1 mm Reflectivity dB) Distance in y Distance in x Ultrasound enhancement caused by the addition of submicron particles

  29. Targeted contrast enhancement for ultrasound Contrast agent Probe

  30. Project 3: Future Developments • Focus on array development • Special emphasis on beamformer • Improve sensitivity and quantitation for flow assessment • Develop, characterize and validate targeted contrast agents

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