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Behaviour

Diseases. Environment . Infectious diseases. Behaviour. Genetics. Drug Discovery and BioMedical research in the 21 st century? The third revolution . The first revolution: The era of incidental discoveries 1930s-1960s. Penicillin. The second revolution 1970s-2000s

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Behaviour

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  1. Diseases Environment Infectious diseases Behaviour Genetics

  2. Drug Discovery and BioMedical research in the 21st century? The third revolution

  3. The first revolution: The era of incidental discoveries 1930s-1960s

  4. Penicillin

  5. The second revolution 1970s-2000s High throughput – brute force screening of large libraries of chemical compounds

  6. Statins Akira Endo

  7. Future medicine- Targeted and Personally “fitted” medicine – Personalized Medicine

  8. Medicine of the 21st Century – The 4P’s Medicine (Leroy Hood) Personalized, Predictive, Preventive, and Participatory Medicine Stem cell-based therapies

  9. Future medicine- Targeted and Personally “fitted” and medicine - Personalized Medicine Breast Cancer – Estrogen Receptor Negative and Positive (predicts sensitivity to Tamoxifen)

  10. The Human Genome Size of the entire Human Genome = 3 Billion Bases

  11. What are the obstacles – they appear to be broader and more complicated than just target identification and validation : • Many diseases (metabolic, psychiatric) are multigenic, and the causative connection between the genes products is not clear • 2. Malignancies are characterized by genomic instability and therefore targets are not stable • 3. Human experimentation is complicated (HRT, stents) • 4. Lack of faithful animal models (neurodegeneration, cancer, metabolic diseases) • Cost of developing new drugs - legal liability (Vioxx/Celebrex), markets (new antibiotics), and patents protection (AIDS - South Africa, India) • End of blockbuster drugs era • 7. Bioethical problems of availability of genetic information

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