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Stalenhoef JE. IDWeek 2013 abs. 750

1 of 2. Intravesical gentamicin (iGM) instillation for recurrent urinary tract infection (rUTI) due to multi-drug-resistant (MDR) bacteria.

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Stalenhoef JE. IDWeek 2013 abs. 750

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  1. 1 of 2 Intravesical gentamicin (iGM) instillation for recurrent urinary tract infection (rUTI) due to multi-drug-resistant (MDR) bacteria Cohort study: N=14 pts (8 ♂; 34-79 yr) with symptomatic rUTI (>3x/yr); MDR bacteria (>3 antibiotic classes) in 12/14 pts; in all, oral prophylaxis had failed iGM (80 mg GM in 20 ml NaCl 0.9%) instillation: During initial phase: daily for 3h or overnight Afterwards: interval varied from every 3rd day to 1x/wk Median treatment (Tx) duration: 42 wk (6-148 wk) Stalenhoef JE. IDWeek 2013 abs. 750

  2. 2 of 2 Intravesical gentamicin (iGM) instillation for recurrent urinary tract infection (rUTI) due to multi-drug-resistant (MDR) bacteria • GM plasma levels at end of instillation (N=12 pts): undetectable (<0.1 mg/l) • No side effects reported iGM installation may suppress symptomatic infection in pts with recurrent UTI due to MDR bacteria where oral prophylaxis has failed Stalenhoef JE. IDWeek 2013 abs. 750 Data from poster

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